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Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contacts with the endoplasmic reticulum and that the lipid exchange protein oxysterol-binding protein (OSBP) is recruited to these sites in a Ca2+-dependent manner.

Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well

Added insulation in cold attics can be an efficient and profitable energy efficiency measure. Simultaneously, added insulation increases the risk of a decreased temperature in the attic, thereby increasing the risk of high relative humidity and moisture damage. This paper collocates and reviews previous publications that deal with the impact of added insulation on attics as a renovation measure. T

Collective intelligence (CI) in demand-side management (DSM) can enhance the flexibility of urban energy systems. Extreme climates cause intensively high loads on the urban energy systems resulting in power outages. To avoid this, quick responses are needed from buildings to adjust their operation in favor of the grid. Most of the available approaches are computationally expensive. CI-DSM offers a

The well-publicized disinformation campaigns surrounding recent elections, pandemic vaccination adoption, as well as supply-chain disruptions and shortages have made historical problems of disinformation more apparent. When disinformation targets transportation infrastructure, supply chains can be disrupted, resulting in commodities shortages such as food and fuel, consequently jeopardizing the he

The purpose of this chapter is to discuss the legal issues relating to cruise ship passenger contracts, their nature and salient features, parties to the contract and their rights and obligations. Claims arising out of passenger carriage subject to applicable law and contracts containing standard terms and conditions are addressed. It is rare for passengers to examine the terms and conditions of t

The concert was part of ZIP VENICE GUITAR FESTIVAL 2024, a format created within the Guitar School of the Benedetto Marcello Conservatory of Music in Venice.Programme Marsilio Ficino (1433-1499) Music is nothing but a decoration of silence Johann Ssebastian Bach (1685-1750) Sarabande and 2 Gavottes from cello suite No 6,BWV 1012 Heitor Villa-Lobos (1887-1959) Mazurka-chôroBach Sarabande from lute

The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study

Lungultraljud har visat god precision och reproducerbarhet som diagnostiskt komplement till klinisk undersökning vid akut dyspné. Lungultraljud utförs bedside och är relativt lätt att lära sig, men kräver träning och strukturerat utförande för att inte resultera i felaktiga diagnoser.Lungultraljud baseras till största delen på tolkning av artefakter. Vid en normalt luftfylld lunga bildas horisonteUltrasound plays an important role in several medical fields. The heart was the first organ for which ultrasound gained clinical utility, followed by obstetric and gynecological applications. Shortly thereafter, abdominal organs and blood vessels became targets for ultrasound examination. The lung was long considered inaccessible for ultrasound due to its high air content. Work since the 1990s has

Med hjälp av öppna datakällor från svenska myndigheter om vatten och mark vilka sammanställdes i ett QGIS-program var det möjligt att presentera och åskådliggöra vattenbudgeten i Lagans avrinningsområden. Den sammanlagda vattenmängden i avrinningsområdet kunde uppskattas till 9,36 km3 varav 75,9 % (7,10 km3) är grundvatten och 24,1% (2,26 km3) finns i sjöarna i området. Studien pekar på att GISbas

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evide

Horizontal logistics collaboration can increase environmental sustainability and reduce shipping costs. Given these benefits—and the fact that few shippers actually opt to collaborate—public sector agencies and industry associations have attempted to sponsor and support the facilitation of horizontal logistics collaboration projects over the past 20 years. The literature, however, has yet to revea

In this chapter, we explore not only the challenges with public procurement, but also how public organization can turn procurement into a useful tool that can help develop quality in public services provision and delivery. There is a belief that public procurement can be an instrument for change. The public sector is a large procurer, and the idea is that if public procurers demand better products

The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study