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The vildagliptin experience - 25 years since the initiation of the novartis glucagon-like peptide-1 based therapy programme and 10 years since the first vildagliptin registration

The discovery of the incretin hormone glucagon like peptide-1 (GLP-1), and its usefulness in the treatment of type 2 diabetes mellitus (T2DM) followed by the finding that dipeptidyl peptidase-4 (DPP-4) inhibition prevents GLP-1 inactivation, led to the discovery of DPP-728. In 1999, studies with DPP-728 established the first proof-of-concept that DPP-4 inhibition improves glycaemic control in pati

Perspective : An extension of the STROBE statement for observational studies in nutritional epidemiology (STROBE-nut): Explanation and elaboration

Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo

Atypisk subakut tyreoidit gav differentialdiagnostiska problem : Ovanligt fall av graves tyreotoxikos i kombination med subakut tyreoidit med atypisk klinisk bild

Subacute thyroiditis is a common inflammatory disorder of the thyroid gland, possibly of viral etiology, that typically presents with neck pain, fever and tenderness on palpation of the thyroid gland. Graves’ disease is an autoimmune thyroid disorder caused by stimulation of the thyroid gland by thyrotropin receptor antibodies (TRAb). The development of Graves´ disease and subacute thyroiditis sim

Assessing cultural ecosystem services as individuals’ place-based appraisals

Though the existence of cultural ecosystem services is dependent on people's activities and experiences, these services are still commonly assessed using top–down approaches. In this study, appraisal theory and research into human responses to natural environments formed the basis of a systematic multilevel investigation of appraisals of created wetland areas. The aim was to explore how appraisals

Roles of PDZ-dependent Interactions and N-glycosylation in G Protein-coupled Estrogen Receptor 1 (GPER1)/GPR30-mediated Stimulation of ERK1/2 Activity

G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor (GPCR) that is attracting considerable attention in breast cancer and cardiometabolic regulation. Following reports that GPR30 is required for some rapid estrogen responses, e.g. increased cAMP production and ERK1/2 activity, in estrogen receptor (ER)-negative cells, GPR30 was renamed G protein-coupled estrogen receptor 1 (GPER1

An analytical tool for long-term dune management

Climate change calls for coastal management to consider longer time scales. The main objective of this study is to develop an analytical tool for long-term dune management to help evaluate the risk associated with high water levels, high waves, and their joint probability, as well as the probability of dune erosion, overwash, and breaching to occur. The tool also aims to identify vulnerable dune s

University Incubators and the Likelihood of Women Entrepreneurship

The principal question we ask in this study is to what extent structural characteristics in the entrepreneurship eco-system surrounding incubators influence the likelihood that women may engage in the commercialization of university science by becoming incubatees. We embed our arguments in institutional theory and develop hypotheses related to (1) the share of female faculty at the closest univers