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Kämpinge Interactive Reporting System

3D recording and visualization is standard practice at the Department of Archaeology and Ancient History at LU. This approach is currently used within several field projects to support documentation, data management and data analysis. The 3D data collected in the field are archived in the faculty server and are made available to researchers and students through the Lund University Digital Archaeol

High tech or high touch? Heritage encounters and the power of presence

In this article, I challenge the increasing emphasis on digital technologies to enhance encounters with the past in heritage landscapes. Beginning with a memory from my childhood, I conceptualise presence as being there and review recent approaches in heritage studies that highlight the wide range of benefits derived from embodied experiences in heritage places including reinforcing feelings of we

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression t

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567-A) is associated with a reduced risk of fibrosis in NAFLD, but the underlying mechanism(s) remains unclear. We investigated the effects of this variant in the human liver and in Hsd17

Digital Transformation of the Automotive Industry : An Integrating Framework to Analyse Technological Novelty and Breadth

Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt

Redistributive effect, progressivity and differential tax treatment : Personal income taxes in twelve OECD countries

This paper decomposes the redistributive effect of the personal income taxes (PITs) of twelve OECD countries into four components: (i) an average rate effect, (ii) a departure-from-proportionality or progressivity effect, (iii) a horizontal equity effect and (iv) a reranking effect. The product of (i) and (ii) indicates the vertical redistribution associated with the PIT and the sum of (iii) and (

Adipose cell size : Importance in health and disease

Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we have summarized the different experimental techniques used to study adipocyte cell size and describe adipocyte size in relation to insulin resistance, type 2 diabetes, and diet interventions. Hypertrophic adipocytes have an impa

Spatial Temperature Differences in Portal Frame Bridges

Thermal actions are considered in the design of bridges, as temperature variations can lead to restraint stresses and subsequent cracking. However, load descriptions are in some cases oversimplified or incompatible with modern applications, and background studies are limited. This paper therefore aims to develop a more detailed load description for the load case describing temperature differences

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This experimental study adapts a usage-based perspective on L2 acquisition (Bybee 2008; Ellis 2008) and focuses on the production of French subject-verb (SV) agreement in number (singular vs. plural). Previous studies show that the acquisition of this agreement is a long and gradual process in L2 French (Bartning & Schlyter 2004; Prévost 2009; Michot 2015). This study examines the influence of

Rules and Tools in the Battle against Superbugs - A call for integrated strategies and enhanced international collaboration to promote antimicrobial drug development

The lack of treatments during the recent Ebola and Zika outbreaks dramatically exposed the vulnerability of the global health system and the dire consequences thereof. But even where therapies against infectious diseases had been available, an additional threat has gained world-wide attention: antimicrobial resistance (AMR). A growing number of microbial organisms are becoming resistant to availab

Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus

OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more

Could Easier Access to University Improve Health and Reduce Health Inequalities?

This paper estimates the impact of university education on medical care use and its income related inequality. We do this by exploiting an arbitrary university eligibility rule in Sweden combined with regression discontinuity design for the years 2003-2013 for students who graduated 2003-2005. We find a clear jump in university attendance due to university eligibility. This jump coincides with a p

Orai channels are critical for receptor-mediated endocytosis of albumin

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channe