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Ghrelin is a regulator of glucagon-like peptide 1 secretion and transcription in mice

The gut hormones ghrelin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) have been intensively studied for their role in metabolism. It is, however, not well known whether the hormones interplay and regulate the secretion of each other. In this study, we studied the effect of ghrelin on GLP-1, GIP, and insulin secretion during an oral glucose tolerance test (OG

Recent advances on CD4+ T cells in atherosclerosis and its implications for therapy

Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, incl

Trade Secrets, Big data and Artificial Intelligence Innovation: a Legal Oxymoron?

This chapter will analyse the Trade secret Directive from a technological informed legal perspective, looking at the possibilities and scope of protection that it offers for knowledge based activities and business models. It opens by restating the basic yet important fact that “Information is power”. Asymmetries in information are a fundamental transaction cost and in this sense informational qual

Socialt kapital och samhällets miniatyrisering

Social capital and the miniaturisation of community. Social capital has been conceptualized both as a contextual property of communities and as a property of individuals. Two of the building blocks of the notion of social capital are social participation and trust. High levels of social participation and trust are reciprocally reinforcing with two-way causality, according to the literature. Howeve

The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functIn the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and funct

Influence of public bus transport organisation on the introduction of renewable fuel

The need to decrease emissions from the transport sector is getting urgent and public transport can play an important role in the transition to low emission fuels. To a large extent, public transport in Europe is provided by regional authorities who controls the traffic to a varying degree, from complete public monopoly to competitive tendering. Therefore, the aim of this paper is to analyse how t

Mapping an emergency management network

We present a web-based method for mapping various relations between agents that have been involved in an emergency response operation. The method is based on combining a web-questionnaire with telephone interviews and it provides an efficient way of collecting large amount of information concerning the agents. By using the resulting network of agents it is possible to perform various network analy

Comparison of the cost of preventing postoperative deep vein thrombosis with either unfractionated or low molecular weight heparin

The relative costs were analysed of (1) no prophylaxis against deep vein thrombosis (DVT), (2) selective treatment of DVT after confirmation of diagnosis, (3) general prophylaxis with standard low-dose unfractionated heparin and (4) general prophylaxis with low molecular weight heparin (LMWH) in patients undergoing elective general abdominal surgery or elective hip surgery. The mean calculated cos

Outdoor environmental assessment of attention promoting settings for preschool children

The restorative potential of green outdoor environments for children in preschool settings was investigated by measuring the attention of children playing in settings with different environmental features. Eleven preschools with outdoor environments typical for the Stockholm area were assessed using the outdoor play environment categories (OPEC) and the fraction of visible sky from play structures