Added insulation in cold attics can be an efficient and profitable energy efficiency measure. Simultaneously, added insulation increases the risk of a decreased temperature in the attic, thereby increasing the risk of high relative humidity and moisture damage. This paper collocates and reviews previous publications that deal with the impact of added insulation on attics as a renovation measure. T

Collective intelligence (CI) in demand-side management (DSM) can enhance the flexibility of urban energy systems. Extreme climates cause intensively high loads on the urban energy systems resulting in power outages. To avoid this, quick responses are needed from buildings to adjust their operation in favor of the grid. Most of the available approaches are computationally expensive. CI-DSM offers a

Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, incl

Abstract: Citizen-state relations can be more than just a political relationship. It can also be emotional. Where there is an articulated balance between citizen tax obligations and state welfare services, there arises a combination of redistribution and reciprocity between citizen and state. This fiscal compact has an emotional component. This emotional component becomes indignation when people p

We investigated early electrophysiological responses to spoken English words embedded in neutral sentence frames, using a lexical decision paradigm. As words unfold in time, similar-sounding lexical items compete for recognition within 200 milliseconds after word onset. A small number of studies have previously investigated event-related potentials in this time window in English and French, with r

In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies suggest mitochondrial ABCB7-type exporters are involved in maturation of cytosolic iron-sulfur proteins. However, the molecular mechanism for how the ABCB7-type exporters participate in this process remains elusive. Here

Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a larg

Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression, treatment, and complications. A data driven cluster analysis in European individuals with T2D previously identified four subtypes: severe insulin deficient (SIDD), severe insulin resistant (SIRD), mild obesity-related (MOD), and mild age-related (MARD) diabetes. Here, the clustering approach was applied to individuals

Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well

TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid Δ9-tetrahydrocannabiorcol (C16) and by probenecid. C16 and probenecid act in concert to stimulate TRPV2 responses including histamine release from

The reaction to Russia’s full-scale invasion of Ukraine in February 2022 indicated a multiplicity of standpoints, different positionalities, and power asymmetries, in particular in the Western academy. Represen-tatives of the mainstream migration research centres as well as individual researchers, while recognising the importance of solidarity with the Ukrainian people and with Ukrainian scholars,

Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt

The construction industry is an important societal sector and a major consumer of energy. Improved energy efficiency is important for this sector, but energy efficiency at construction sites has so far been under-researched. The aim of this article is to analyse the drivers of and barriers to improved energy efficiency at construction sites, as perceived by professional actors. The peer-reviewed r

Background: The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health-related outcomes such as death are limited. We addre

EU law increasingly requires that the Member States establish independent administrative bodies in various fields. Examples include market supervision, non-discrimination, and data protection. This article addresses the realisation of such requirements in the five Nordic states. The West Nordic systems of Denmark, Iceland, and Norway feature a traditional hierarchic organisation of the administrat

What is the relationship between trust and the quality of political institutions in a society? According to an influential cultural perspective, social trust—the belief that most people can be trusted—is a value inculcated during individuals’ formative years, and remains fixed afterward. A second perspective holds that social trust reflects experiences throughout the life course, particularly inte