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Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen

This thesis has evaluated the immunological- and epidemiological aspects of human papillomavirus transmission dynamics and its effect on circumcision. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope is defined by the monoclonal antibody H16.V5. To investigate the importance of this epitope for overall immunogenicity of HPV16, we en

Background: The primary aim of this paper is to describe the design of a project evaluating the effects of using a research-based strategy for managing housing adaptations (HAs). The evaluation targets clients' perspectives in terms of activity, participation, usability, fear of falling, fall incidence, use of mobility devices, and health-related quality of life, and determines the societal effect

Uncultivated field margins are one of the most frequent non-crop habitat types in contemporary, highintensity agricultural landscapes and may therefore be important for the persistence of many farmland species. Managing field margins in a way that preserves, and preferably enhances, their value for biodiversity is therefore important. In the present study, we evaluate how the flora of uncultivated

Due to increased awareness of climate change and higher energy costs, well‐insulated buildings have become more common. Furthermore, the interests of using wood in building to produce more carbon dioxide‐efficient houses have increased. However, thicker thermal insulation in walls increases the risk of high relative humidity levels and the risk of mould‐related damage in Wood frame houses. In orde

Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis. Objective:Our objective was

Objective To examine the long-term effects of early low-dose prednisolone use in patients with rheumatoid arthritis (RA) on cardiovascular (CV) morbidity and mortality. Design Retrieval of data from a 2-year open randomised trial comparing prednisolone 7.5mg/day in addition to disease-modifying antirheumatic drugs (DMARDs) with DMARD therapy alone. Participants were followed for 10years since incl

In a previously published study, vildagliptin showed a reduced risk of hypoglycemia versus glimepiride as add-on therapy to metformin at similar efficacy. Glimepiride was titrated from a starting dose of 2 mg/day to a maximum dose of 6 mg/day. It is usually assumed that the increased hypoglycemia with glimepiride was driven by the 6 mg/day dose; it was therefore of interest to assess whether the r

Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and barley. Similar to other autoimmune diseases such as type 1 diabetes, psoriasis and rheumatoid arthritis, celiac disease is the result of an immune response to self-antigens leading to tissue destruction and production of autoantibodies. Common d

Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are chara

Medical geography usually attempts to disentangle and explain the ecological and causal contexts of health, disease and environment by mapping spatial patterns of cases and potential pathogenic factors. However, many diseases are believed to show after long periods of latency , spanning years and even decades between initial exposure and clinical onset. In view of high spatial human mobility - in

In this thesis, different optical methods utilising visible light for characterization of tissue have been developed and evaluated. The feasibility of many of these methods has been demonstrated in the laboratory or in animal experiments. However, the goal is naturally to develop methods useful in the clinic, and thus the emphasis in this thesis has been put on in vivo examinations. Raman spectro

Allvarliga tillbud och olyckor inom flygtrafiken är relativt ovanligt, men när de inträffar ställs höga krav på kabinpersonalens förmåga att uppträda auktoritativt och effektivt. Det är dock inte bara vid ett direkt olyckstillbud det ställs stora krav på kabinpersonalens förmåga att hantera kritiska situationer. Det finns en hel flora av incidenter som kräver professionell hantering, t ex när passAlthough serious accidents or near-accidents are relatively rare in airline traffic, when they occur cabin attendants are expected to act effectively and with authority. However, the ability of cabin attendants to intervene professionally is also called for in other critical situations, such as when incidents that are frightening for the passengers occur or when passengers suddenly become ill. The

Developing a reliable and quantitative assessment of the potential virulence of a malignancy has been a long-standing goal in clinical cytometry. DNA histogram analysis provides valuable information on the cycling activity of a tumor population through S-phase estimates; it also identifies nondiploid populations, a possible indicator of genetic instability and subsequent predisposition to metastas

Children with severe diseases can be provided nutritional support through a gastrostomy if needed. At the Department of Paediatric Surgery in Lund we have used the Video Assisted Gastrostomy (VAG) procedure since 1994 when establishing gastrostomies. In this thesis, children with different diseases, who all had undergone the VAG procedure, were studied in five different clinical studies. Postopera

The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret