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High body mass index is associated with increased risk for osteoarthritis of the first carpometacarpal joint during more than 30 years of follow-up

Introduction Osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obe

The impact of initial treatment strategy and survival time on quality of end-of-life care among patients with oesophageal and gastric cancer : A population-based cohort study

BACKGROUND: Oesophageal and gastric cancer are highly lethal malignancies with a 5-year survival rate of 15-29%. More knowledge is needed about the quality of end-of-life care in order to understand the burden of the illness and the ability of the current health care system to deliver timely and appropriate end-of-life care. The aim of this study was to describe the impact of initial treatment str

Displaced femoral neck fractures in patients 60-69 years old – mortality and patient reported outcomes in a register cohort

Registerstudie på data från Svenska Frakturregistret, SFR. Vi hittade 723 patienter i åldern 60-69 år som hade en dislocerad höftfraktur. Standardbehandling i Sverige är total höftplastik, men en del patienter behandlas även med skruvar/spikar. Patienter med skruvar/spikar måste opereras om i 1/3 av fallen pga haveri i frakturen och erhåller då total höftplastik. Trots detta uppvisade denna grupp BackgroundSeveral randomized studies have compared arthroplasty and internal fixation (IF) and found better patient reported outcome measure (PROM) and fewer reoperations for arthroplasty. But consensus is lacking regarding which method to use in the "young elderly” patients aged 60-69; IF tend to fail in up to 1/3 of the cases but can offer the benefits of a biologically intact hip if successful.

Gender, autoantibodies, and obesity in newly diagnosed diabetic patients aged 40-75 years

OBJECTIVE - To evaluate the frequency of autoimmune markers (islet cell antibodies [ICA] and glutamic acid decarboxylase antibodies [GADA]) and clinical features in newly diagnosed people with diabetes aged 40-75 years. RESEARCH DESIGN AND METHODS - Two hundred fifty-nine consecutive patients (aged 40-75 years) with newly suspected diabetes diagnosed during a 2-year period were studied. The diagno

Gambling disorder, increased mortality, suicidality, and associated comorbidity : A longitudinal nationwide register study

BACKGROUND AND AIMS: Gambling disorder (GD) appears to be an independent risk factor for suicide, and all-cause mortality has been sparsely studied in patients with GD. This study aims to explore mortality and suicide rates in individuals with GD compared to the general population as well as explore risk factors associated with all-cause mortality and suicide mortality. METHODS: This is a nationwi

Associations of perinatal characteristics with endometriosis : a nationwide birth cohort study

BACKGROUND: Perinatal characteristics are associated with subsequent risk of several chronic diseases. Previous studies regarding endometriosis were based on small samples and retrospective data and were limited by unmeasured confounding bias, leading to conflicting and inconclusive findings. We investigated the associations of maternal and birth characteristics with risk of endometriosis among Sw

Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness

OBJECTIVE: While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortalit

Early Revascularization after Admittance to a Diabetic Foot Center Affects the Healing Probability of Ischemic Foot Ulcer in Patients with Diabetes.

There is limited information about whether time from recognition of decreased perfusion to revascularization affects the probability of healing in a patient with a diabetic foot ulcer. The aim of the present study was to examine whether time to revascularization after referral to a multidisciplinary foot center was related to the outcome of foot ulcers in patients with diabetes and severe peripher

Technical infrastructure networks as socio-technical systems : Addressing infrastructure resilience and societal outage consequences

Research area: Modern society is increasingly dependent on a range of technical infrastructure networks including e.g. power, transport and IT networks. This dependence is illustrated by large disturbances which from time to time affect these systems, often to an extent which few did consider possible.The overarching aim of this thesis is to advance analysis methods concerning large disturbance ev

Caesarean Section on The Risk of Celiac Disease in the Offspring : The Teddy Study

OBJECTIVE:: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS:: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental D