Most complex diseases have well-established genetic and non-genetic risk factors. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks. Characterizing these gene-environment interactions may help elucidate the biology of complex diseases, as well as to guide strategies

The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six

To identify stop-codon variants associated with blood pressure (BP).

OBJECTIVE: Our objective was to identify characteristics of infants and their families who were enrolled, refused to enroll, or were excluded from The Environmental Determinants of Diabetes in the Young (TEDDY) study. METHOD: 16,435 infants screened at birth and identified as at increased genetic risk for type 1 diabetes (T1DM) were placed into one of three categories: enrolled, excluded, or refus

BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their

This study deals with research on the visual organ as pursued in experimental physiology during the latter half of the nineteenth-century. In the 1850's och 60's experimental physiology developed as a new, scientific discipline within the curriculum of western medicine. By opposing the natural philosophical and vitalistic viewpoint of romantic medicine and by proclaiming measuring devices, animal

Design To study the association between mode of delivery and neonatal mortality in second twins. To study the association between caesarean delivery and mortality with minimum bias of the indication for the operation, we wanted to compare the outcome of second twins delivered by caesarean due to breech presentation of the sibling with vaginally delivered second twins in uncomplicated pregnancies.

Baltoskandien utgör en del av paleokontinenten Baltica, vilken mestadels var täckt av ett grunt epeiriskt hav under den ordoviciska tidsperioden (ca 485,5–444 Ma). Detta uråldriga hav efterlämnade en tunn lagerföljd av sedimentära bergarter. Under tidig–mellanordovicium (ca 485,5–457,5 Ma) befann sig Baltica vid tempererade breddgrader på södra halvklotet och kallvattenkarbonater bildades över stoThe Baltoscandian region forms part of the paleocontinent Baltica, which was largely covered by a shallow epeiric sea throughout much of the Ordovician (c. 485.5–444 Ma). This ancient sea is today recorded by a thin succession of sedimentary rocks. During the Early–Middle Ordovician (c. 485.5–457.5 Ma), Baltica was situated in mid-latitudes on the southern hemisphere and cool-water carbonates form

Global teaching and learning for sustainable development reaches from the classroom to the world outside, and is therefore a particularly interesting setting for practising transition skills. The article suggests a number of features perceived as crucial in developing young people's capability to act in a changing world and under circumstances that are difficult to predict. The suggestions are bas

This study investigates the effects of Age of Onset of Acquisition (AOA) and the quality and quantity of input on the longitudinal development of gender in the acquisition of French by simultaneous (2L1) and successive bilingual children (cL2). There's an on-going debate regarding the main factors underlying linguistic development in bilingual children. Two independent variables, AOA and input, ha

High quality of warfarin treatment is important to prevent recurrence of venous thromboembolism (VTE) without bleeding complications. The aim of this study was to examine the effect of individual time in therapeutic range (iTTR) and International Normalised Ratio (INR) variability on bleeding risk and mortality in a large cohort of wellmanaged patients with warfarin due to VTE. A cohort of 16612 p

This thesis consists of three self-contained papers that all relate to the understanding of equality. The first chapter investigates the effects of preschool attendance on children in Kenya and Tanzania. We use a within-household estimator and data from nationally representative surveys of school-age children's literacy and numeracy skills, which include retrospective information on preschool atte