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The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug
Abstract: Background : Anorecta l malformation s (ARM) occur in 4: 10000 newborn children with the gender distribut ion 1:1.5 females:males. The reconstruction of ARM, posterior sagiccal anorectal plasty (PSARP), was implemenred worldwide in the late 1980s and therefore the follow-ups are limited. Aims: To assess bowel symptoms in children and adolescents with ARM, operated on with PSARP, and to
Partly due to an ageing population, the number of osteoporosis-related fractures and osteoarthritis (OA)-related hip and knee arthroplasty procedures is increasing. The individual suffering and the burden on society for these conditions is immense. Genetic contribution for the variance in bone mineral density (BMD) is estimated at around 60–80%, and for OA 50%, leaving a considerable proportion to
Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. The aim of this thesis was to investigate the basic mechanisms behind leukocyte-platelet-end
Strong and independent associations between plasma concentration of cystatin C and risk of cardiovascular disease (CVD) suggests causal involvement of cystatin C.
Leisure Activities in Rheumatoid Arthritis. Associated Factors and Assessment. Leisure activities were considered to give intrinsic pleasure, meaning and value to life already in ancient Greek. It was also performed for its own sake and not by consideration of any external rewards. In the beginning of the 20th century leisure was only possible for wealthy people who could occupy themselves with n
Chronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive inflammation and presence of bacteria. The overall aim of this thesis has been to explore the pathogenesis of t
The author (professor of Scandinavian linguistics, *1934, living in Lund or nearby) compares his own dialect with that of his mother (house-wife, *1912, living nearly all her life 15 kilometers outside Kalmar). Interestingly, he found very few differences. The article discusses why.
Atoms and molecules absorb and emit light at certain, welldefined wavelengths, and this forms the basis of spectroscopy. The wavelengths are given by the discrete energy levels of the atoms/molecules. When illuminated by light of a suitable wavelength, the light will be absorbed, making it possible to deduce information on the presence and concentration of various elements and compounds. When ato
The aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire
Control of the upright stance and locomotion is a complicated process of muscular activity. The muscular activity is dependant on afferent information from the different sensory organs and interpretation in the central nervous system. Age-related degenerative changes exist in all the domains concerned with control of posture. The aims of the studies were to investigate if suspected age-related de
Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote
Association to specific host tissue structures allows pathogenic bacteria to establish an infection and facilitates the spread within its host. Interactions between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is al
