Filetype
Diesel engines are widely used as powertrain solutions for transportation vehicles. Their low fuel consumption and high performance make them attractive, however, their associated pollutant emissions is a major drawback which represent a hazard for public health and the environment. Therefore, the concentrations of the major pollutant species are regulated. Soot, which to a large extent consists
Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. The current research paradigm regarding spontaneous and steroid-induced clearance of airway tissue eosinophils exclusively involves death through apoptosis followed by p
In acute pancreatitis (AP), lung injury is an early occuring and important part of the multiple organ dysfunction syndrome. The mechanisms underlying the development of lung injury though still largely remains unclear. The aim of the present study was to study mechanisms of the systemic and secondary pulmonary inflammation and injury, with an emphasis on the involvement of immune cells, inflammato
Amyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein
The aim of this thesis was to identify the influence of calcium, physical activity and detraining on bone mass and bone size in girls and young women. We hypothesised that calcium intake above a specific level does not enhance the accrual of bone mineral, that exercise predominantly influences the skeleton in the early pubertal period and that reduced training is followed by a loss of exercise-ind
Stroke is the most common life-threatening neurological disease and ranks as the third leading cause of death in major industrialized countries. It is also the leading cause of serious long-term disability and about sixty percent of survivors have disabilities in their extremities. Recovery of certain neurological functions occurs over time, which has been attributed to endogenous restorative proc
Poor ergonomics in production systems can compromise performance and cause musculoskeletal disorders (MSDs), which pose a huge cost to society, companies, and afflicted individuals. This thesis presents a research trajectory through the problem space by: 1) Identifying and quantifying workplace risk factors for MSDs, 2) Identifying how these risks may relate to production strategies, and 3) Develo
In this thesis, retinal function in general, as well as central retinal function and structure are described in selected forms of acquired and hereditary retinal disorders, in order to improve our understanding of underlying pathogenic mechanisms. This comparison has been made possible during the last years, through the relatively recent development of multifocal ERG (mfERG) and optical coherence
New institutionalist approaches are inherently weak at accounting for institutional change. In this book, social network analysis is proposed as a key to institutional change. The social network perspective focuses emergent patterns of interpersonal interaction and the resulting ties of interpersonal trust. As a complement and contrast to both March and Olsen’s influential new institutionalist "lo
The Malmö Preventive Project, a preventive, case-finding programme for cardiovascular risk factors and alcohol abuse was created in 1974 at the Department of Preventive Medicine of Malmö University Hospital. Between 1974-1992, a total of 22 444 men (mean age 44 years range 27 - 61) and 10 902 women (mean age 50 years, range 28 - 58) attended the programme, with an overall attendance rate of 70% (r
The aim of this thesis was to evaluate cervical physiological changes by three-dimensional (3D) ultrasound during pregnancy and to investigate the ability of 3D power Doppler to predict time to spontaneous and induced delivery in prolonged pregnancy. The thesis is based on five studies: reproducibility of cervical measurements by 3D power Doppler ultrasound (study I), reference data representativ
This thesis is about women in drug abuse treatment and their descriptions of themselves as women - their process of becoming feminine. The aim of the thesis is describing and trying to understand the meaning of the treatment in the women's femininity processes and what significance drugs, alcohol, men, the own body, motherhood, and sexuality have and have had in the process. The emphasis is on the
This thesis consists of three theoretical essays on the acquisition of skills in teams. The first essay deals with the training and recruitment of football players in the European Soccer leagues. Before 1995, the transfer system entitled the ceding football club compensation from the acquiring football club when, on the expiry of his contract, the player in question moved to another club. In 1995,
Multi-dimensional, laser-based measurements of quantities important for obtaining a better understanding of combustion processes, particularly of temperature and of species distributions, were performed using laser-induced fluorescence (LIF). The main purpose of the temperature experiments was to investigate the potential of employing a two-line atomic fluorescence technique (TLAF), using indium a
Two key events in the oncogenic process of tumor cells are to acquire uncontrolled proliferation and invasive properties. This allows the tumor to grow and invade beyond the tissue from which the tumor cells originate. We here specifically studied p16 and ERK1/2 with special focus on and the relation to proliferation and invasion in non-melanoma skin cancer and in breast cancer. In a model system
The prime mover in the world today is the Internal Combustion (IC) engine. The development and improvement of the internal combustion engines since Nicolaus August Otto and Rudolf Diesel has continued until today and will continue long into the future. No major competitor to the IC engine has yet emerged. There is a long list of potential competitors but they still have to prove their superiority
Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular system but also active within the airways. The importance of its proinflammatory and co-mitogenic properties has become increasingly evident, the endothelin system also having been shown to mimic the signal features of asthma, COPD and other pulmonary diseases. The present thesis concerns the role of th
The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. Subsequently, MTGR1 (Myeloid Translocation Gene-Related protein 1
The external ventricular drain (EVD) is an important instrument in the management of neuro-intensive care patients through its ability to meassure intracranial pressure and to treat increased intracranial pressure by drainage of cerebrospinal fluid (CSF). However, EVDs are associated with the risk of external ventricular drain related infection (EVDRI). EVDRI diagnosis is challenging as symtoms an
