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The available bandwidth in wireless communication systems, such as the 802.11 family, is very limited. Together with the ever increasing data traffic, this causes problems. New possibilities are, however, available thanks to wide license-free bandwidth allocated at higher frequencies. Increased available bandwidth enables higher data rates in future radio systems that will be capable of Giga-bit/s
This thesis concerns a numerical investigation on heat transfer in internal combustion engines, with the aim of increasing engine efficiency. The efficiency gains are to be extracted from reduced heat transfer losses, by increasing the knowledge on how the heat transfer process is affected by various hardware and operational parameters in the engine. The engines concerned are both conventional die
The interaction between an intense laser pulse and a gas medium leads to the emission of coherent bursts of light in the extreme ultraviolet range. This process, known as high-order harmonic generation, has today, almost three decades after its discovery, developed into a reliable source of extremely short (on the order of 100 as) pulses of electromagnetic radiation, with a wide range of applicati
Airborne particles are everywhere around us, and have always been. Particles generated by human activities has increased drastically since industrialization, and several epidemiological studies have shown that inhaled particles can cause adverse health effects. The concern about health effects have during the last decade shifted towards fine and ultrafine particles, not least due to the emerging f
This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. The second part of the thesis deals with how embryonic stem cells rid themselves of damaged p
Chlorinated fatty acids (ClFAs) are the major contributors of extractable, organically bound chlorine in fish lipids. A known anthropogenic source of ClFAs is chlorine bleached pulp production. Additional anthropogenic sources may exist, e.g., chlorine-containing discharge from industrial and house-hold waste and they may also occur naturally. ClFAs have a wide geographic distribution. They have,
Amongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una
This thesis deals with large eddy simulations (LES) of turbulent combustion processes in direct injection internal combustion (IC) engines. Modeling of direct injection IC engine combustion involves modeling of turbulent spray/gas two-phase flow, modeling of chemical reactions of large hydrocarbon fuels and coupling of chemistry with turbulent flows. LES is chosen in this thesis for it capability
Macroporous hydrogels are regarded as interesting materials both within biotechnology and biomedicine due to their properties. These materials can be prepared from a wide range of synthetic or naturally occurring compounds using a number of different techniques for their production. For this thesis, cryostructuring was used to prepare macroporous hydrogels, often named cryogels. The work utilized
The cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhes
Vision is an important source of information for many animals. The lens plays a central role in the visual pathway and hence the ecology of these animals. Fish have spherically shaped crystalline lenses that contain a gradient of refractive index. Like all refracting elements, lens performance depends on the wavelength of the refracted light. This wavelength dependent focusing leads to chromatic a
A sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
My identity in the eyes of myself and others [translated title]. The purpose of this study was to examine how teenage girls experience their identities and how it is constructed and influenced by external factors. It was also an attempt to illustrate how mass media and social media like Facebook and blogs can be elements in the construction of identities. Berger and Luckmann‟s social construction
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for 15-20 years. To date no effective treatment is available for curing the disease. HD primarily affects the striatum, cerebral cortex and hypothalamus. At later stages cell death is evident in the striatum
The purpose of this thesis was to increase the understanding of altered movement patterns in individuals with anterior cruciate ligament (ACL) injury in order to improve ACL rehabilitation, and to develop an observational instrument termed Test for Substitution Patterns (TSP) for standardized, quantifiable scoring of altered movement patterns in legs and trunk. In all, 142 participants, 93 with A
Coordination of policies embracing biomass use has been called for in order to speed up progress towards the European Union renewable energy and climate change goals. Policy coordination and coherence is also required if the many complex and diverse issues constraining sustainable bioenergy development are to be addressed. To contribute to meeting such needs this doctoral thesis provides insights
Abstract Therapeutic hypothermia (TH) is the only treatment available to reduce neurological sequels for unconscious patients following cardiac arrest (CA). TH requires sedation and muscular relaxation, obscuring the clinical neurological examination for estimation of prognosis, and clinical decision making. Continuous amplitude-integrated EEG (aEEG) has been used to predict outcome in neonates
The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. The V1-V3 region of the HIV-1 env gp120 is important for HIV-1 corecept
Background: A prognostic marker should provide information about course and outcome of disease, e.g. predict time to a given endpoint or rate of progression due to disease in patients or subgroups of patients. Prognostic markers could be targeted to apply during the entire clinical course or just during distinct stages of the disease. Aim: The aim of this thesis is to identify, review and qualif
L-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski
