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This paper constructs a new chronology of the business cycle in the United Kingdom from 1700 on an annual basis and from 1920 on a quarterly basis to 2010. The new chronology points to several observations about the business cycle. First, the cycle has significantly increased in duration and amplitude over time. Second, contractions have become less frequent but are as persistent and costly as at
In many fields of science, solving large sparse systems of linear equations is a critical task. Direct solvers often fall out favour due to their high computational costs and memory requirements. Iterative solvers alleviate this issue but run the risk of converging slower than satisfactory when the associated matrix is ill-conditioned and has poorly distributed eigenvalues. This work will focus on
Fascineras du också av hjärnan och dess komplexitet men också av hur nya tekniker och den snabba utvecklingen inom bioteknologi kan öppna upp för helt nya behandlingar? Då kan vår forskning vara något för dig! Vårt fokus är på att utveckla avancerade terapier såsom cell- och genterapi för Parkinsons sjukdom. Vi arbetar också hårt för att hitta ett botemedel för en av de mest fruktansvärda sjukdomaAre you intrigued by the brain and its complexity, as well as by new technologies and the amazing developments in biotechnology? Then our research may be for you. Our main focus is on developing advanced therapeutical medical products (ATMPs), such as cell and gene therapy for Parkinson's disease. We are also working to treat one of the most devastating disorders of the human brain: glioblastomas,
Abstract While outcome studies in pediatric obesity have received considerable attention, research on different components of effective interventions remains limited. Little is known which psychological method (i.e., behavior modification, cognitive behavior therapy and family therapy) is most useful or how the choice of program delivery (group/individual) influences the intervention outcomes. Gro
Pinus sylvestris (tall) är en betydelsefull trädart i Sverige och Europa, både ekonomiskt och kulturellt sett. Trädet infekteras dock av den destruktiva rottickan (Heterobasidion spp.) vilket resulterar i stora ekonomiska förluster inom skogsindustrin, med en uppskattad monetär förlust på ca 800 miljoner EUR årligen i Europa. Det är svårt att upptäcka svampen i tidiga infektionsstadier eftersom inPinus sylvestris (Scots pine) is an important tree species in Sweden and Europe, both economically and culturally. However, the highly destructive root rot fungi Heterobasidion spp. infect P. sylvestris and cause major economic losses in the forest industry, estimated to about 800 million EUR annually in Europe alone. Detection of the fungus in early stages is hard, as the infection mainly stays i
More reliable and faster prediction methods are needed to interpret enormous amounts of data generated by sequencing and genome projects. We have developed a new computational tool, PON-P2, for classification of amino acid substitutions in human proteins. The method is a machine learning-based classifier and groups the variants into pathogenic, neutral and unknown classes, on the basis of random f
Impactful applications such as materials discovery, hardware design, neural architecture search, or portfolio optimization require optimizing high-dimensional black-box functions with mixed and combinatorial input spaces. While Bayesian optimization has recently made significant progress in solving such problems, an in-depth analysis reveals that the current state-of-the-art methods are not reliab
Impactful applications such as materials discovery, hardware design, neural architecture search, or portfolio optimization require optimizing high-dimensional black-box functions with mixed and combinatorial input spaces. While Bayesian optimization has recently made significant progress in solving such problems, an in-depth analysis reveals that the current state-of-the-art methods are not reliab
Uppsatsen har undersökt huruvida spelföretaget Star Stable Entertainment AB marknadsföring av virtuella valutor och produkter till barn bryter mot EU:s konsumentskyddslagstiftning i ljuset av Sveriges Konsumenters anmälan mot företaget. Uppsatsen har även diskuterat om direktivet om otillbörliga affärs-metoder är anpassat för den digitala miljön med hänsyn till kommissionens aktuella fitness checkThe essay analyses whether the gaming company Star Stable Entertainment AB´s marketing of virtual currencies and other virtual products against chil-dren violates EU consumer law, considering the Swedish Consumers Associ-ation’s complaint against the company. The paper also discusses whether the Unfair Commercial Practice Directive (UCPD) is fit for the digital environ-ment, given the European Com
Foundations of buildings and structures are laid with various methods, both deep and shallow foundations. Piling is the most common method of deep foundations while spread footings are often used in shallow foundations, especially in buildings with column frame. An alternative is to use a composite pile foundation where piles and spread footings or piles and a base slab are used to carry the loads
The Summary for Urban Policymakers (SUP) initiative provides a distillation of the IPCC reports into accessible and targeted summaries that can help inform action at city and regional scales. Volume I in the series, What the Latest Physical Science of Climate Change Means for Cities, identified the ways in which human-induced climate change is affecting every region of the world, and the cities an
Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg
