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Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts

Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf

Impact of neoadjuvant therapy on short-term outcomes after left pancreatectomy : A propensity score–matched international multicenter study

Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und

Classification of postoperative pancreatic fistula after left pancreatectomy : International multicentre cohort study

Background Postoperative pancreatic fistula (POPF) is a major complication after left pancreatectomy. The current International Study Group of Pancreatic Surgery classification has limitations, including heterogeneity in morbidity and high interobserver variability. This study aimed to assess POPF-related morbidity after left pancreatectomy and propose a refined classification system. Methods Pati

Treatment-related amyloid clearance (TRAC) : a framework to characterize patients in the era of anti-amyloid therapies

Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

HLA genotyping in the international Type 1 Diabetes Genetics Consortium

Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loc

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma. The use of nivolumab in previously untreated patients with advanced melanoma has not been tested in a phase 3 controlled study. METHODS We randomly assigned 418 previously untreated patients who had metastatic melanoma w

t(6;9)(p22; q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients

Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells

Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion. In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion. This increases the risk o

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n

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No. 1 2019 M O D E V E T E N S K A P Vid Lunds Universitet H Ä L S N I N G F R Å N S T UD I E R Å D E T Modevetare, mitt i julledigheten vill vi rikta ett stort tack till er för en lyckad julsittning! Vi hade en väldigt trevlig kväll och hoppas att ni hade lika roligt som oss. Under hösten har studierådet drivit ett case som handlar om att integrera modevetenskapen med övriga utbildningar på campu

https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/Ma__nadsbrev_januari_2019.pdf - 2026-06-15

201106 maa25 digi LQ

2020 1995 Trust, a Core Condition Malmö Art Academy 25 Years M a lm ö A r t A c a d e m y , F a c u lt y o f F in e a n d P e r f o r m in g A r t s , L u n d U n iv e r s it y Trust, a Core Condition 1 2 3 4 5 6 7 8 9 10 11 12 5 11 22 37 47 59 83 99 115 128 145 173 181 192 Foreword Timeline Studio Visits Matts Leiderstam Concentric Pedagogy: Towards an Ethics of the Observer Mary Kelly Collective

https://www.khm.lu.se/sites/khm.lu.se/files/2021-01/201106_maa25_digi_LQ.pdf - 2026-06-16

Tro och heder på spel: 33 § avtalslagen efter ”Nätkasinot” – Om en gammal generalklausuls nya spelplan

The essay examines the application of Section 33 of the Contracts Act (SFS 1915:218), with particular focus on the Supreme Court’s (HD) ruling in the case ‘Nätkasinot’ (T 607-24, 1 July 2025). Section 33, which addresses good faith and honour, has rarely been applied by the courts but has recently gained renewed relevance through the ‘Nätkasinot’ judgment. The purpose of the essay is to analyse th

Hellraiser : om Clive Barkers film

Popular Abstract in Swedish Jag kommer i denna avhandling att resonera kring frågor om skräckfilm som genre och studera hur Hellraiser förhåller sig till dess teman och problem. Hellraiser är en skräckfilm och således, på gott och ont, bunden till en kontroversiell genre. Jag anser det omöjligt att frångå detta i min analys där jag bland annat studerar ondska, sexualitet och genus. Efter en presenIn this dissertation I will discuss horror film as a genre and study how Hellraiser relates to its themes and problems. First I describe the production of the film and after that I present Clive Barker - his background, authorship, film-making and artwork. Next I study the problems of the genre and the different ways in which this genre is defined. I look at narrative characteristics as well as, f

Vibration analysis for condition monitoring of mechanical presses

Ger pressar dig bra vibrationer? Idag är allt från kaffemaskiner och gräsklippare till krutpistoler och bilar uppkopplade och kan närsom-helst ge oss en statusrapport genom bara ett par klick i en app. Vi kan med mobilen kolla bilens bräns-lenivå, geografiska position eller om vi glömt att låsa på väg in från par-keringen. Så varför skulle inte statu-sen på utrustningen som används för att tillveIn a world where the concept of just-in-time has been lifted outside of the manu-facturing world and onto the market, the increasing demand of luxury wares like cars is accompanied only by tougher industrial conditions and no room for error. Loss of productivity and decrease in efficiency can be devastating to any manufac-turing company in today’s market climate. One of the largest causes of these