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A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells

Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion. In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion. This increases the risk o

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4

Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts

Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18

TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

Associations of clinical, psychological, and sociodemographic characteristics and ecological momentary assessment completion in the 10-week Hypo-METRICS study : Hypoglycaemia MEasurements ThResholds and ImpaCtS

Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r

Luvre167

fågelåret 2020210 LUVRE 2020 (sedan 2016), snötäcke på fjällheden i juni (i större skala sedan 2018, pilotstudier sedan 2012), hum- lor, fjärilar och vilda däggdjur (inkl. spår, ren ingår inte) på fjällheden (start 2019). LUVRE har med åren blivit ett ganska brett miljöövervakningspro- jekt! För en kort historik om projektet samt grundläg- gande information om de olika långtidsprojekt som drivs, s

https://www.luvre.lu.se/sites/luvre.lu.se/files/2021-11/Luvre167.pdf - 2025-09-26

Utlysning Slutlig SVE

Forskningsnämnden Utlysning av universitetsgemensamma medel – Tvärvetenskapliga projekt med fokus på Agenda 2030 och hållbar utveckling Syfte och mål Lunds universitet avsätter upp till 100 mnkr till en universitetsgemensam satsning på excellens vid Lunds universitet med fokus på Agenda 2030 och hållbar utveckling. Av denna summa används en del för en ny satsning på doktorandtjänster inom forskars

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2021-03/Utlysning%20slutlig%20SVE.pdf - 2025-09-26

Styrelsen 2023-05-09 Protokoll

LUNDS UNIVERSITET Sida 1 av 5 PROTO KOLL CAMPUS HELSINGBORG Samrnantradesdatum 2023-05-09 Diarienummer STYR 2023/1082 U tveckl i ng sen heten Protokoll Campus Helsingborgs styrelse Narvarande ledamoter Lena Eski lsson Charlotta Johnsson Christofer Edling Annika Olsson, digitalt Patrik Lindskoug Kristina Akesson, digitalt, lamnade vid punkt 8. Olof Sundin, digitalt Mattias Wengelin, digitalt, lamna

https://www.ch.lu.se/internt/sites/ch.lu.se.internt/files/2023-11/Styrelsen%202023-05-09%20protokoll.pdf - 2025-09-26

Utlysning Slutlig SVE 0

Utlysning av universitetsgemensamma medel – Tvärvetenskapliga projekt med fokus på Agenda 2030 och hållbar utveckling 1 Forskningsnämnden UTLYSNING 20210315 STYR 2021/682 Utlysning av universitetsgemensamma medel – Tvärvetenskapliga projekt med fokus på Agenda 2030 och hållbar utveckling Syfte och mål Lunds universitet avsätter upp till 100 mnkr till en universitetsgemensam satsning på excellens v

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2021-03/Utlysning%20slutlig%20SVE_0.pdf - 2025-09-26

Arsrapport MH FINAL 2023 1

Årsrapport 2004 för Enheten för medicinens historia, Medicinska Fakulteten, Lunds universitet 1 Årsrapport 2023 för Enheten för medicinens historia, Medicinska Fakulteten, Lunds universitet Enheten för medicinens historia har under året 2023 fortsatt sin verksamhet som en fristående enhet inom Institutionen för kliniska vetenskaper (IKVL) i Lund (prefekt Mikael Bodelsson), tillhörande sektion 5. E

https://www.medicinhistoria.lu.se/sites/medicinhistoria.lu.se/files/2024-01/Arsrapport_MH_FINAL_2023_1.pdf - 2025-09-26

SIMR50 FINAL 210827

SIMR50 FINAL 210827 1 Version 1.0 – March 2021 GRADUATE SCHOOL FIELD COURSES SIMR50 Fieldwork AUTUMN 2021 2 1. WELCOME SIMR50 FIELDWORK Contact info Graduate School e-mail: master@sam.lu.se Home page: graduateschool.sam.lu.se Facebook: tinyurl.com/LUgradschoolFB Student Union Home page: samvetet.org Lund University Home page: http://lunduniversity.lu.se The university is on Youtube, Facebook and T

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-08/SIMR50%20FINAL%20210827.pdf - 2025-09-26

Sylvain Richoz

Senior lecturer Contact details Email: sylvain [dot] richoz [at] geol [dot] lu [dot] se Phone: +46 46 222 78 89Organisation Department of Geology Visiting address: Sölvegatan 12, Lund Room number: 310 Service point: 16 WebpageSylvain Richoz profile in Lund University research portalMy research is focused on:1) the interactions between climate-induced change in seawater chemistry and palaeoecologic

https://www.geology.lu.se/sylvain-richoz - 2025-09-25

LUbaspresentation-2025-ENG

Lund University 2022 Lund University 2025 | EDUCATION, RESEARCH AND COLLABORATION SINCE 1666 1 Nine Faculties and several world-leading research fields. 2 Faculty of Engineering – LTH Faculty of Science Faculty of Law Faculty of Social Sciences Faculty of Medicine Joint Faculties of Humanities and Theology School of Economics and Management Faculty of Fine & Performing Arts Campus Helsingborg Scho

https://www.staff.lu.se/sites/staff.lu.se/files/2025-03/LUbaspresentation-2025-ENG.pptx - 2025-09-26

Microsoft Word - HILMA 2007-12-19.doc

Microsoft Word - HILMA 2007-12-19.doc HILMA Historiska Institutionen i Lund Meddelar Att… Årgång 33, 2007/08, Nr 7, 2007-12-19 Underlagen till HILMA förvaras i pärmar som står i rum 209, på hyllan ovanför faxen. Där hittar du ytterligare information om seminarier, anställningsvillkor, stipendier och annat samt ansök- ningsblanketter i förekommande fall. De sistnämnda, som är samlade i en separat p

https://www.hist.lu.se/fileadmin/_migrated/content_uploads/hilma_ht07_7_03.pdf - 2025-09-25

Interna nätverk

Hanterade av Lunds universitets gemensamma förvaltning Här listas universitetsgemensamma interna nätverk som finns vid Lunds universitet och som utgår från den gemensamma förvaltningen. Listan är uppdelad efter sektion. Syftet är att ge en samlad bild av vad som finns och underlätta för dig som vill nå ut eller få information. Sektionen EkonomiSektionen Forskning, samverkan och innovationSektionen

https://www.medarbetarwebben.lu.se/organisation-och-styrning/organisation/interna-natverk - 2025-09-25

KursbudgetmallVT23

Kursbudget Välj kurs VT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-12/KursbudgetmallVT23.xlsx - 2025-09-26