Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54

Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia a

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r

Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n

Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion. In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion. This increases the risk o

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4

Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18

Brevmall Postadress Box 117, 221 00 Lund, Besöksadress Paradisgatan 5 Telefon 046-222 30 31 eller 046-222 00 00 E-post asa.bergenudd@bygg.lu.se Webbadress www.lu.se Rektor Föreskrift avseende intern upplåtelse av lokal inom Lunds universitet Beslutad av rektor 2021-09-23. Med stöd av 2 kap 5§ högskolelagen (1992:1434) föreskriver universitetet följande; 1. INLEDNING 1.1 Syfte Föreskriften reglerar

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2021-11/Foreskrift-avseende-intern-upplatelse-av-lokal-inom-Lunds-universitet.pdf - 2025-07-06

1 Frank Heller SVINDLARE, KOSMOPOLIT, FÖRFATTARE UTSTÄLLNING PÅ UNIVERSITETSBIBLIOTEKET I LUND FEBRUARI – JUNI 2022 2 3 Dr Serner och Mr Heller Gunnar Serner var under pseudonymen Frank Heller Sveriges mest framgångsrike underhållningsförfattare under 1900-talets första hälft. Sammanlagt skrev han fler än femtio böcker, de allra flesta i äventyrs- genren. Han blev mest känd för böckerna om den små

https://www.ub.lu.se/sites/ub.lu.se/files/2022-02/utstallningskatalog-frank-heller.pdf - 2025-07-06

Kursbudget Välj kurs HT22 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-06/KursbudgetmallHT22_0.xlsx - 2025-07-06

Kursbudget Välj kurs HT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2023-09/KursbudgetmallHT23.xlsx - 2025-07-06

Allm studieplan hälsovet 2017 Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se Medic inska faku l te tss tyre lsen Allmän studieplan för utbildning på forskarnivå inom det hälsovetenskapliga området - arbetsterapi, omvårdnad, fysioterapi http://www.med.lu.se/utbildning/forskarutbildning (Fastställd av Medicinska f

https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-halsovetenskaper-2017-01-01.pdf - 2025-07-06

Kursbudget Välj kurs VT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-12/KursbudgetmallVT23.xlsx - 2025-07-06

Kursbudget Välj kurs VT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2023-06/KursbudgetmallVT23.xlsx - 2025-07-06

Kursbudget Välj kurs VT24 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2024-04/KursbudgetmallVT24.xlsx - 2025-07-06

Kursbudget Välj kurs HT24 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2024-08/KursbudgetmallHT24.xlsx - 2025-07-06