Filetype
Introduction: Investigation of bone marrow (BM) trephine biopsies and/or clot sections by CD34 immunohistochemistry (IHC) testing has been used by pathologists for several decades, and its clinical value has been well established with QBEND10 being the most frequently used primary antibody (Ab) clone. However, most other parameters related to the IHC protocol as well as the readout vary widely bet
Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular
For some time now, IR has been experiencing a narrative turn, with an increasing number of empirical analyses using the concept. However, its ontological, epistemological and methodological assumptions and implications are not always addressed. The panel aims to facilitate a conceptual debate on three sets of questions: Ontology: How does our understanding of the concept depend on the social theor
Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials were done in late-stage patients that have advanced nigrostriatal degeneration and may therefore not re
This thesis concerns the principle of provenance and its applicability in the archival processing of personal digital archives. Digital archives are here understood as archives consisting of born-digital material and not analogue material that has been scanned and digitized. Personal archives are understood simply as collections of documents from private persons, as opposed to businesses or organi
Popular Abstract in Swedish Avhandlingen behandlar skolverksamheten i en svensk medelstor kommun under perioden 1996-2005 med fokus på de delar av verksamheten som handlar om stödåtgärder för elever med skolsvårigheter Syftet med studien är att undersöka skolans bedömning av elevers skolsvårigheter i ett längre perspektiv, och innefattar bl.a. elevers subjektiva upplevelser och konsekvenser i skoThis thesis examines school activity in a medium-sized Swedish municipality 1996?2005 focusing on the parts of the activity that deal with support measures for pupils with school difficulties. The purpose of the study is to examine the assessment of pupils? school difficulties in a longer perspective, considering pupils? subjective experiences and consequences of the school's organisation and wor
Popular Abstract in Swedish För att skydda sig mot infektioner har människan ett välutvecklat immunförsvar. I immunförsvaret ingår många olika celler och proteiner (äggviteämnen). Till exempel finns det celler som producerar antikroppar som specifikt känner igen bakterier och virus som en människa har utsatts för vid en tidigare infektion. Det finns också speciella celler som kan fagocytera (äta uMany microorganisms have developed mechanisms to protect themselves against attack from the complement system of the host. One possible mechanism for a microorganism to evade complement attack is to bind a human complement regulator, which may allow the microorganism to down-regulate complement activation. This thesis describes studies of such interactions between human C4b-binding protein (C4BP),
Popular Abstract in Swedish Diabetes är en världssjukdom – om 50 år räknar det internationella diabetesförbundet med att en tiondel av världens befolkning har någon form av diabetes. Diabetes innebär att kroppen inte kan ta hand om allt socker som man äter. Detta medför att sockerhalten i blodet blir för högt. Högt blodsocker gör att kroppens celler arbetar konstant, och om blodsockret är för högtThe primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. This has been investigated in three different studies, which concluded the following: Study 1) GPR30 is expressed in female mice pancreatic isle
Popular Abstract in Swedish Olika toleransmekanismer kontrollerar immunsystemets aktivitetThe immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. This thesis work is based on investigations of different tolerance mechanisms induced in CD4+ T lymphocy
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING IMMUNFÖRSVARET OCH KOMPLEMENTSYSTEMET Till skydd mot infektioner har människan sitt immunförsvar. Här ingår till exempel vita blodkroppar och en mängd olika proteiner. En viktig grupp av proteiner kallas för komplementsystemet, vilket består av ca 30 proteiner som kan angripa bakterier och andra oönskade partiklar och delta i för-störThe ability of many pathogenic microorganisms to cause infection is dependent on their ability to evade attack by the complement system of the host. One mechanism by which microorganisms may avoid complement attack is to bind complement inhibitory molecules present in the host. This thesis describes studies of the complement inhibitor C4BP and of inter-actions between C4BP and the human pathogen
Isolation of the male and female DNA is one of the most important steps in obtaining the DNA profile of the perpetrator in sexual assault cases. The sample is obtained by taking a vaginal swab containing both epithelial cells from the female and sperm cells from the male from the victim. The purity of the extracted male fraction decides whether or not a single-source DNA profile of the suspect wil
Popular Abstract in Swedish Även om vi befinner oss i en tidsepok av informationsteknologi och superdatorer så utförs dagens forskning baserat på Galileos vetenskapliga principer. Trots det så finns det idag inget behov av att klättra upp i det lutande tornet i Pisa för att observera hur ekvationerna för rörelse, enligt den klassiska mekaniken, tar sig uttryck för fallande kroppar. Samma experimenRecent years have witnessed a growing interest of the scientific community for the use of ab initio and density functional theory methods in theoretical studies of molecules containing many atoms. However, the `scaling wall' of some of the most accurate of such methods is often an obstacle for their applicability to systems of real-life interest, e.g. in biochemistry and nanotechnologies, one bott
In the developed countries the public expect society to be prepared for, and step in, if something out of the ordinary happens. This public pressure appears to have increased the demand for crisis preparedness planning. In crisis management the local authority serves as the first line of defence and will more or less always be involved in responding to crises. It is therefore important to study ho
Popular Abstract in Swedish I avhandlingens fokus står förhållandena på Kosta glasbruk under perioden 1820-1880. Glasbruket som grundades år 1742 är en av de många mindre svenska bruksbildningarna. Under hela undersökningsperioden måste glasbruket ses som förhållandevis litet med som mest ett 80-tal hushåll direkt knutna till glasbrukets industriproduktion. Glasbruket hade liksom flertalet svenskaThis thesis focuses on the circumstances at the glassworks of Kosta during the years 1820-1880. The glassworks founded there in 1742 was but one of many small Swedish rural works. Throughout the period in question, the glassworks can be seen as a small-scale factory with about 80 households directly engaged in industrial production. Like the rest of the glass industry, the glassworks at Kosta deve
It has previously been shown by the authors that the pre-chamber ignition technique operating with fuel-rich pre-chamber combustion strategy is a very effective means of extending the lean limit of combustion with excess air in heavy duty natural gas engines in order to improve indicated efficiency and reduce emissions. This article presents a study of the influence of pre-chamber volume and nozzl
Consistent individual effort in engagement in HIV medical services has been associated with positive health outcomes in people living with HIV (PLHIV). However, whether these benefits are facilitated by improved medication adherence has not been widely studied. This study aimed to investigate the marginal effect of engagement in HIV care on medication adherence at a public health facility in Kenya
Objective. Ankylosing spondylitis (AS) is a progressive, debilitating disease with complex symptoms, unclear etiology and pathogenesis, and difficult diagnosis. Current imaging methods are useful in diagnosing AS and other spondyloarthropathies, and are frequently used in investigations of sacroiliitis. The radiographic diagnosis of sacroiliitis has large interobserver variations. Computed tomogra
Goodpasture disease fulfils all criteria for a classical autoimmune disease, where autoantibodies targeted against the non-collagenous domain of the alpha3-chain of collagen IV initiates an inflammatory destruction of the basement membrane in kidney glomeruli and lung alveoli. This leads to a rapidly progressive glomerulonephritis and severe pulmonary hemorrhage. Previous studies have indicated a
We have examined the variations in gene content and sequence divergence that could be associated with symbiotic adaptations in the ectomycorrhizal fungus Paxillus involutus and the closely related species Paxillus filamentosus. Strains with various abilities to form mycorrhizae were analysed by comparative genomic hybridizations using a cDNA microarray containing 1076 putative unique genes of P. i
Popular Abstract in Swedish Medborgarlön - ett statligt bidrag som ges till alla medborgare utan inkomst- eller behovsprövning - har varit flitigt diskuterat inom akademiska kretsar under senare år. Bland argumenten för medborgarlön återfinns att det antas ge ett erkännande åt obetalt arbete inom hemmet, en mer jämlik fördelning av lönearbete genom att uppmuntra deltidsarbete, leda till minskad ofBasic income - an income granted by the government to each full member of society without means tests or work requirements - has been a widely discussed subject among academics in recent years. However, basic income has not, in most cases, reached the formal political agenda. The main aim of this book is to discuss why this is the case, with Sweden as the focus of the discussion. The aim is also t
