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Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulate

BACKGROUND: Malignant melanoma is the most deadly form of skin cancer. Female sex is known to have a protective effect on incidence, tumour characteristics, and mortality from melanoma. However, the potentially modifying effect of sex on the prognostic significance of clinicopathological and investigative factors is generally not taken into consideration in biomarker studies. In this study, we com

N-acylated substituted β 3 oligoamides are known to form unique supramolecular nanorods based on a 3-point hydrogen bond self-assembly motif. This motif is an intermolecular extension of the hydrogen bonding network that stabilizes the 14-helix secondary structure unique to β 3 oligoamides. Acetylation of the N-terminus of the molecule provides the necessary third hydrogen bond pair of the motif.

Cryptosystems based on the learning with errors (LWE) problem are assigned a security level that relates to the cost of generic algorithms for solving the LWE problem. This includes at least the so-called primal and dual lattice attacks. In this paper, we present an improvement of the dual lattice attack using an idea that can be traced back to work by Bleichenbacher. We present an improved distin

The behavioural variant of Alzheimer’s disease (bvAD) is characterized by early predominant behavioural changes, mimicking the behavioural variant of frontotemporal dementia (bvFTD), which is characterized by social cognition deficits and altered biometric responses to socioemotional cues. These functions remain understudied in bvAD. We investigated multiple social cognition components (i.e. emoti

Denna avhandling behandlar spridning av lätta mesoner i fallet där antalet externa mesoner överstiger fyra (d.v.s. tre eller fler partiklar i initial- eller finaltillståndet), beräknat genom kiral störningsräkning. Detta är både av teoretiskt intresse inom studien av spridningsamplituder, och relevant för system av tre eller fler pioner som simuleras genom gitter-kvantkromodynamik.Introduktionen hThis thesis concerns scattering of light mesons in the case where the number of external particles exceeds four (that is, three or more particles in the initial or final state), calculated using chiral perturbation theory.This is both of theoretical interest in the study of scattering amplitudes, and relevant for systems of three or more pions simulated using lattice quantum chromodynamics.The int

De senaste åren har den svenska sockerkonsumtionen debatterats flitigt i media. Att Sverige skulle införa en sockerskatt för att minska den höga konsumtionen har föreslagits av såväl akademiker som politiker. Trots att ett införande av en svensk sockerskatt har föreslagits i en rad riksdagsmotioner, har dessa avslagits gång på gång. Debatten har trots detta fortsatt, och att den till slut kommer uIn the past few years the high sugar consumption has been a concern in Sweden as well as world wide because of the health problems it may lead to. As a result of the increased sugar consumption, some countries have introduced a tax on sugar to reduce the consumption. In Sweden there is an ongoing debate concerning a possible introduction of this kind of tax, but the Swedish tax committee has rejec

Cities affected by the impacts of climate change have to find new ways to adapt to the variability in weather patterns, such as heavy rainfalls and storms. The coastal city Malmö, a former industrial city, aims to be carbon neutral by 2020 and provided by 100 percent renewable energies in 2030. However, Malmö is facing many environmental and socio-economic challenges. One of these challenges is to

Med ett politiskt parti anklagat för fascism i riksdagen, och nynazister marscherande på gatorna är frågor om demokrati och frihet viktigare än någonsin. Var bör yttrandefrihetens gränser dras? Bör den överhuvudtaget begränsas? Syftet med den här uppsatsen är att utforska en möjlig lösning till de problem som dagens demokrati står inför. Det här åstadkoms genom en konstruktion av ett konceptuellt With a political party accused of fascism in the Swedish parliament and neo-nazis marching in the streets, questions of democracy and freedom of expression are as important as ever. Where to draw the boundaries of the freedom of expression? Why have, or limit, such freedoms in the first place? The purpose of this thesis is to investigate a possible solution to the problems facing contemporary demo

Induction machines have been used in a wide range of applications due to its robustness and its low price. These characteristics make the induction machine a suitable option for industrial and home environments especially for those applications where the required speed is constant and the load does not change drastically. As an alternative to the induction machine, the synchronous machine, particu

Avtalslicensbestämmelserna ger en nyttjare rätt att, på vissa i upphovsrättslagen angivna områden, träffa avtal om användning av upphovsrättsligt skyddade verk med en organisation som företräder ett flertal svenska upphovsmän på området. Genom avtalslicensen får användaren även rätt att nyttja verk av det slag och på de villkor som preciseras i avtalet av upphovsmän som inte är medlemmar av den avThe extended collective licenses grant a user the right to, under provisions that are stated in the Swedish Act on Copyright in Literary and Artistic works, enter agreement about exploitation of works with an organization that represent a substantial number of Swedish authors in the field concerned. Thanks to the extended collective license, the user is granted the right to use works protected by

Den här uppsatsen handlar om nedskräpning, insamling och återvinning av plast på Bali i Indonesien. På grund av osäkra avfallshanteringssystem, brist på kunskap och få incitament för insamling, har plastavfall en tendens att hamna i naturen där det sedan förorenar mark och vatten, och därmed utgör en risk för djurs och människors hälsa. Genom en fallstudie av den vinstdrivande och sociala organisaThis thesis studies plastic littering, collection and recycling on Bali in Indonesia. Due to unsound waste management systems, low awareness and few incentives for collection, plastic waste has the tendency to leak to the environment, where it pollutes land and water, and poses a threat to wildlife and human health. With a case study of the for-profit social enterprise the Plastic Bank that trades

Macaque politics and influential infants How infants influence social behaviour in adult Barbary macaques To befriend or not to befriend? Under what circumstances do animals act friendly to each other, and when do they act aggressively? Amid the dynamic and turbulent social landscape of macaque societies, individuals need to constantly evaluate their ever-changing social landscape. Family ties, f

Wheel of Fortune or Academy of Vice? : Economic Ideals and Threats in the Swedish Lottery Debate, 1809–1840. This master’s thesis examines how ideas pertaining to economic and moral behaviour, ideals and threats were expressed, shaped and understood in the public debate about the state lottery – kungliga nummerlotteriet – in Sweden during early nineteenth century. At the time, state lotteries wer

Fildelningsteknologin revolutionerade internet i början av 1990-talet. I rask takt har fildelningsnätverken utvecklats och utbudet av olovligen tillgängliggjorda filer är större än någonsin. För vanliga internetanvändare innebär nyss nämnda gratis tillgång till film och musik vid efterfrågan. Det kan emellertid medföra stora ekonomiska förluster för rättighetshavarna till verken. Digitaliseringen File sharing technology revolutionized the Internet in the early 1990s. Different networks evolve at a rapid pace and the supply of illegally spread files are greater than ever. For common Internet users this means free, on-demand access to movies and music. However, it may cause major financial losses to the right-holders of copyrighted works, since the digitalization often times means losing con

Rising costs of healthcare in most OECD-countries have contributed to a quest for research into the field of healthcare costs and efficiency, something that has not been free of controversies. As a result of that, healthcare financers as well as providers have become more inclined to measure performance and compare themselves to others with the same responsibilities. In Sweden, the Association of

Sveriges regering satte 2011 upp mål om att bli bäst på att utnyttja digitaliseringens möjligheter. Digitaliseringen av bygglovsprocessen har trots det gått långsamt. Bygglovsprocessen idag (2018) är en långsam, dyr och ineffektiv process. Möjligheten att söka bygglov med e-legitimation finns endast hos 30 procent av kommunerna och 60 procent har någon slags e-tjänst ansökan. Ansökningarna innebärThe Swedish government set up a goal in 2011 of making the best use of digitization opportunities. The digitization of the building permit process has, however, been slow. The process of building permits is today (2018) a slow, expensive and inefficient process. The possibilities to apply for building permits with e-credentials is only available in 30 percent of municipalities and 60 percent have

Due to the globalization with free labour transfer, migrant workers are unavoidably the most targeted group for human trafficking business. Trafficking in persons is a global issue because of its engagement with the international organized crime. Apart from that, as the Protocol on Trafficking in Persons has been in force since 2003, States have turned their attention to the issue and many of them

Syftet med denna framställning är att utreda och analysera säljarens ansvar vid informationsgivning till potentiella köpare i samband med förhandlade företagsöverlåtelser. Säljaren vill med sin information till köparen få målbolaget att framstå som så attraktivt som möjligt, han vill med andra ord göra en så god affär som möjligt inom de ramar som lagen ställer upp. Huvudfrågan som uppsatsen sökerThe purpose of this thesis is to investigate and analyze vendor's liability for disclosure of information to potential purchasers of unlisted shares. The seller wants the target company to appear as attractive as possible; in other words he wants to make the most favorable deal possible within the limits of the law. The main question in this thesis is to analyze what information and circumstan

In this study child pornography offence and more stringent measures against child pornography on the Internet are discussed. Furthermore, the study explores several ways and means of effectively combating child pornography. Thus, the intention with this essay is to consider various provisions that should be taken in order to achieve a more effective combating of child pornography on the Internet.