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Background and objective: The most common way of closing the cystic duct in laparoscopic cholecystectomy is by using metal clips (>80%). Nevertheless, bile leakage occurs in 0.4%–2.0% of cases, and thus causes significant morbidity. However, the optimal number of clips needed to avoid bile leakage has not been determined. The primary aim of this study was to evaluate bile leakage and post-procedur
The story of human rights corporate accountability is not a story of a move towards stringent international and transnational regulations. One discussion nowadays is whether the UN Guiding Principles on business and human rights (UNGPs) should be hardened into law. Regulations on human rights due diligence (HRDD) would increase access to remedies forvictims, hold lead firms legally liable for thei
OBJECTIVE: To assess the progression of type 1 diabetes using time to peak glucose or C-peptide during oral glucose tolerance tests (OGTTs) in autoantibody-positive relatives of people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We examined 2-h OGTTs of participants in the Diabetes Prevention Trial Type 1 (DPT-1) and TrialNet Pathway to Prevention (PTP) studies. We included 706 DPT-1 partic
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many of such systems are prepared by complicated processes where fibers are produc
Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical and population-based evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might play a role in preventing CRC. We performed a nationwide cohort study to explore whether the use of SSRIs could reduce CRC risk among individuals with family history. We identified individual
Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulating the release of small bioactive molecules. In the current study, we aimed to elucidate the identity
This study investigates how digital technology is used (or not used) in home care nursing, to identify challenges and opportunities that can move the digitalization of home care nursing forward. The use of digital technology in daily practices of home care nursing was analyzed based on semistructured interviews in four Swedish home care organizations. The results correspond to the two initial stag
Accurate monitoring of the spatiotemporal variations in the gross primary productivity (GPP) in coastal wetlands is essential for blue carbon quantification. However, the currently available moderate-spatial-resolution GPP algorithms and products may contain large uncertainties and may rarely meet the demands of tidal wetland research. In this paper, we examine two statistical methods, namely, sim
Popular AbstractStörre kriser och katastrofer som stormen Gudrun och dess konsekvenser är sannolikt att vänta i framtiden. Det råder dock ovisshet om vilka kriserna kommer att vara och under vilka förutsättningar. Nya och kompletterande vetenskapliga studier och metoder inom kris- och katastrofforskningen måste till för att öka samhällets kunskap om och förmåga att hantera kända och okända hotbildSevere crises and disasters such as the Hurricane Gudrun and their consequences will probably occur in the future. However, there are many uncertainties concerning disasters and their effects. New scientific approaches and methods for crisis and disaster research must be developed to increase the knowledge and ability of societies to manage known and unknown threats. Substantial research on the em
Abstract in UndeterminedThis thesis investigates the growth and application of antimonide heterostructure nanowires for low-power electronics. In the first part of the thesis, GaSb, InSb and InAsSb nanowire growth is presented, and the distinguishing features of the growth are described. It is found that the presence of Sb results in more than 50 at. % group-III concentration in the Au seed partic
This paper presents a theory to quantify the informational value of human acts. We argue that living is functioning against entropy. Acting is presented as a set of decisions and choices to create order that we use as the foundation to develop the concept of complexity of human acts. Frequency theory of probability is then applied to characterize human acts in terms of their degree of freedom and
Background: Free oxygen radicals have been implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants. Superoxide dismutase (SOD) is a naturally occurring enzyme which provides a defense against such oxidant injury. Providing supplementary SOD has been tested in clinical trials to prevent BPD in preterm infants. Objectives: To determine the efficacy and safety of SOD in
A new series of orally available α-d-galactopyranosides with high affinity and specificity toward galectin-1 have been discovered. High affinity and specificity were achieved by changing six-membered aryl-triazolyl substituents in a series of recently published galectin-3-selective α-d-thiogalactosides (e.g., GB1107 Kd galectin-1/3 3.7/0.037 μM) for five-membered heterocycles such as thiazoles. Th
OBJECTIVES: To investigate whether the relative effectiveness of janus kinase inhibitors (JAKis) versus tumour necrosis factor inhibitors (TNFi) or other biological disease-modifying antirheumatic drugs in rheumatoid arthritis differ by the presence or absence of risk factors for cardiovascular (CV) disease, age, sex and smoking. METHODS: Through Swedish registers, we identified 13 493 individuals
En välkänd svårighet för inlärare av L2-svenska är komplexiteten kring definithet, bestämdhet och artikelbruk (DBA). Flera studier har indikerat att inlärare som saknar morfologisk bestämdhetsmarkering i sitt L1 har svårare för strukturer inom DBA, men att även inlärare med motsvarande strukturer i sitt L1 har rapporterats ha svårigheter. I denna artikel redogör vi för hur den komplexitet som DBA A well-known difficulty for learners of L2 Swedish is the complexity of definiteness in form and meaning, together with article use. Several studies have indicated that learners lacking morphological definiteness in their L1 struggle more with structures within this area although learners with corresponding structures in their L1 also have issues. This article describes how this area’s complexity
Aviation is a highly inter-connected system. This means that a problem in one area may cause effects in other countries or parts of the Air Transport System (ATS). Examples range from local air traffic disruptions to the 2010 volcanic ash crisis. Agility, like resilience, refers to the ability to cope with dynamics and complexity in a flexible manner, by adjusting and adapting performance and the
Skiljeförfarande är i svensk rätt jämställt med tvistlösning i allmän domstol beträffande dispositiva tvistemål. Grunden för tvistlösning genom skiljeförfarande, är ett skiljeavtal mellan parterna. Huruvida en uppkommen tvist ska lösas genom skiljeförfarande – när det finns ett skiljeavtal parterna emellan – är avhängigt skiljeavtalets (objektiva) omfattning. Skiljenämnden saknar behörighet att avArbitration is, according to Swedish law, equivalent to court proceeding, when it comes to dispositive disputes. The basis of dispute resolution through arbitration, is an arbitration agreement between the litigants. Whether a dispute should be resolved through arbitration – when there is an arbitration agree-ment between the litigants – is dependent on the scope of their arbitration agreement. Th
