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Aims/hypothesis The aims of this project was to investigate the effect of glucolipotoxic treatment on DNA methylation and gene expression patterns in pancreatic islets and functionally test if and how these changes alter insulin secretion. Methods Genome-wide mRNA expression and DNA methylation patterns were analyzed in human pancreatic islets after control or glucolipotoxic treatment. Alterations
Både den svenska och den norska lagstiftningen präglas av en strävan att få föräldrar att nå enighet i frågor om vårdnad, boende och umgänge. Denna strävan grundar sig i att en samförståndslösning mellan föräldrarna, i större utsträckning än ett domstolsavgörande, antas vara till barnets bästa. I Norge är det därför obligatoriskt med medling för alla föräldrar med barn under 16 år innan de kan väcBoth Swedish and Norwegian legislation is characterized by an effort to get parents to reach consensual agreement, in matters of custody, residence and contact. This strive is based on the fact that a consensual solution between the parents, to a greater extent than a court decision, is assumed to be in the best interest of the child. In Norway, mediation is therefore mandatory for all parents wit
Crime prevention is an important part of the police duties and a part of increasing security in society. Crime prevention can be long-term projects, where some of the work might be visiting schools to promote children and teenagers from future crimes, or short-term projects when possible crimes are prevented in place. One type of crime prevention is to show the most crimefrequent locations with th
This study investigates the relationship between social investments and public transport. The purpose is to determine the state of knowledge with regards to social investments and public transport, and if possible determine the factors necessary for this to succeed. To outline the concept of social investments within the framework of transport economics, a thorough review of the relevant theory, a
This is a bachelor thesis using qualitative methods to investigate people in insecure socio- economic situations. The purpose of this thesis is to, in an explorative way, investigate, both theoretically and empirically, what people in insecure socio-economic situations have in common, in what ways they differ from each other, and where they can be placed in a class structure. For this purpose, 6 p
This bachelor’s thesis is written by Emma Derwinger and Johanna Boman (2023), Division of Fashion Science Studies, Lund University. The study titled “Hellre medveten än hållbar?” aims to analyze and understand the use of traceability within the fashion- and textile industry and how relevant this tool of awareness is for consumers today. Approaching the topic, this paper focuses on an interview wit
In this master thesis work, the effect of polarization, at the Base Station (BS) side, on the performance of multi-user Coordinated Multipoint (CoMP) systems is studied. This study was performed using synchronous multi-link measurements that took place at the campus of the faculty of Engineering, LTH, Lund University, Lund, Sweden, where two different BS setups were studied. In the first setup, on
Flooding of urban areas is a worldwide problem as cities grow and the amount of impermeable surfaces increase generating more surface runoff. In the Zambian city of Ndola, the capital of the Copperbelt Province, flooding occurs in some parts of the city especially on Dag Hammarskjöld Drive at the underbridge, which has been flooding every rainy season consecutively for 8 years now. The main object
Swedish primary care is under a lot of pressure and struggle to keep up with the big patient flow. An alternative to visiting a physical primary care centre is to visit Min Doktor which is a digital healthcare centre offering doctor visits online that help patients with diagnosis, prescriptions and referrals. Today, Min Doktor’s service is only treating people from the age of 18 but they are curre
Given the increase in electricity prices in recent years due to two reasons; the rebound effect after the initial corona outbreak and the Russian invasion of Ukraine, the burden of paying the rising monthly expense for electricity has become an unwelcome reality for a significant part of society. The electricity trades on the open market called Nord Pool for the Nordic countries, among others, whe
The purpose of this essay is to analyze the socio-economic development plans for Haiti after the earthquake of 2010, made by the government of Haiti and the International Community. The analysis will be carried out through the use of a key document- the Action Plan, and will be examined by the use of two theoretical frameworks. By using the two theories, they give an overview on what can be done w
The aim of this paper was to examine opinions among professionals on which refugee children have the best versus the worst conditions to attain a favourable adaption in their new country. This was investigated through the conceptions of resilience and in consideration of the importance of gender and different methods of treatment. I have found that there are three subgroups of factors that are of
Objective: To develop and initially test a new questionnaire to be used to investigate former ICU patients physical and psychosocial needs/problems and if it change over time. Design: A questionnaire was developed based on the Likert scale. The items were generated from literature search and from personal experiences of follow up visit. SF 12 was used to assess the questionnaires concurrent validi
This study investigates Swedish critical entities (CEs) ability to maintain function during up to three months of electricity supply disruptions. It also examines possible improvement measures, and how contextual cases (grey zone, heightened state of alert, war) influence CEs’ ability to maintain function during electricity supply disruptions. Expert elicitation was conducted with experts from eig
This master thesis investigates how the county administrative boards communicate the regional risk and vulnerability analyses to municipalities in Sweden. Information has been gathered through a survey and through a case study involving three county administrative boards. The results revealed that there are possibilities to improve or develop the communication in all the county administrative boar
Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. In this study, we discovered 128 genome-wide significant associations (P < 5 × 10 -8) in a multi
The ongoing Internet of Things revolution has led to strong demand for low-cost, ubiquitous light sensing based on easy-to-fabricate, self-powered photodetectors. While solution-processable lead-halide perovskites have raised significant hopes in this regard, toxicity concerns have prompted the search for safer, lead-free perovskite-inspired materials (PIMs) with similar optoelectronic potential.
A search for an antigen-driven expansion of T lymphocytes in the inflamed joints in rheumatoid arthritis (RA) patients have been going on for decades. We here analyzed the human germinal centre T-cell receptor (TCR) Vbeta gene usage with polymerase chain reaction (PCR) combined with sequence analysis, to address the question of clonality in tonsils and synovial tissue from RA patients. Our data sh
After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where
