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Background: Metastatic castration resistant prostate cancer (mCRPC) is a bone dominant lethal disease. Progression in bone scan of mCRPC disease is assessed with the Prostate Cancer Working Group (PCWG) two and three criteria, which relies on the appearance of two or more new lesions. There is an unmet need for a quantitative assessment that can build on the current progression criteria. This thes

We analysed the role of the prechordal plate in forebrain development of chick embryos in vivo. After transplantation to uncommitted ectoderm a prechordal plate induces an ectopic, dorsoventrally patterned, forebrain-like vesicle. Grafting laterally under the anterior neural plate causes ventralization of the lateral side of the forebrain, as indicated by a second expression domain of the homeobox

In the early decades of the 17th century, when the idea of the Swedish colony of New Sweden was conceived and realized, America had a vague place in popular consciousness. Knowledge of the new continent was rather limited, and early Swedish images of it were influenced by tales told by foreign travellers and sailors, by pictorial representations in prints and maps, and by news and reports publishe

We consider the two-dimensional problem for steady water waves with vorticity on water of finite depth. While neglecting the effects of surface tension we construct connected families of large amplitude periodic waves approaching a limiting wave, which is either a solitary wave, the highest solitary wave, the highest Stokes wave or a Stokes wave with a breaking profile. In particular, when the vor

Relict spinel grains (similar to 25-250 mu m in diameter) from decomposed extraterrestrial material in Archean to Recent sediments can be used to reconstruct variations in the flux of different types of meteorites to Earth through the ages. Meteorite falls are rare and meteorites weather and decay rapidly on the Earth surface, making it a challenge to reconstruct ancient fluxes. Almost all meteori

To investigate whether preoperative retinal function measured by full-field ERG and multifocal ERG is correlated to postoperative visual acuity after macular hole surgery.

We construct three-dimensional families of small-amplitude gravity-driven rotational steady water waves of finite depth. The solutions contain counter-currents and multiple crests in each minimal period. Each such wave is, generically, a combination of three different Fourier modes, giving rise to a rich and complex variety of wave patterns. The bifurcation argument is based on a blow-up technique

Using harmonic maps we provide an approach towards obtaining explicit solutions to the incompressible two-dimensional Euler equations. More precisely, the problem of finding all solutions which in Lagrangian variables (describing the particle paths of the flow) present a labelling by harmonic functions is reduced to solving an explicit nonlinear differential system in C-n with n = 3 or n = 4. Whil