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The centenarian Tröger’s base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. All three diastereomers showed unprecedented stability to acid
This article summarizes content proceedings of a symposium held at the 2004 International Society for Biomedical Research on Alcoholism Congress in Mannheim, Germany. The chairs were Boris Tabakoff and Friedrich M. Wurst. The presentations were (1) Genetic associations with alcoholism and affective disorders, by Paula Hoffman; (2) Proteomic analysis of blood constituents in alcoholism, by Boris Ta
Cellular uptake of several viruses and polybasic macromolecules requires the expression of cell-surface heparan sulfate proteoglycan (HSPG) through as yet ill-defined mechanisms. We unexpectedly found that among several cell-surface binding scFv anti-HS antibody (alphaHS) clones only one, AO4B08, efficiently translocated macromolecular cargo to intracellular vesicles through induction of HSPG endo
Popular Abstract in Swedish Spraytorkning är ett vanligt sätt att tillverka partiklar från en lösning. Genom att finfördela lösningen med hjälp av gas i ett spraymunstycke bildas miljontals små vätskedroppar, som blandas med varm torkgas i en torkkammare. Då avdunstar vätskan och fasta, torra partiklar bildas. Tekniken kan användas för att tillverka inhalationspartiklar för användning som läkemedeThe interest in spray drying for production of inhalable particles has grown considerably since the late 1980s. However, which process variables that control degradation and the solid state properties have not been subject to extensive research. This thesis deals with how important characteristics of inhalation particles can be controlled, i.e. particle size, morphology, degradation and crystalli
This study investigated conceptions of decision quality and efficiency held by administrative officers from three Swedish public authorities (the Tax Board, the Social Insurance Agency, and the Police Authority) with respect to decisions made for other people. Research on conceptions of decision quality held by decision makers making decisions for themselves shows that decision outcome is emphasiz
With worldwide population aging, increasing numbers of people need hospital care. Evidence suggests comprehensive geriatric assessment (CGA) is superior to usual care. To summarize the evidence for the effects of CGA in frail and moderately frail patients compared with usual care in acute care settings. CINAHL, PsycInfo, Cochrane Library, EMBASE, and PubMed were searched in October 2011, January 2
Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di-or trimethylated at Lys 4 and H3K27me3; histone H3 trim
Chemical hypersensitivity reactions induced in the skin or in the respiratory tract are important health concerns and develops following repeated exposure to certain chemicals, termed sensitizers. To prevent such hazardous compounds from entering the consumer market, legal frameworks within EU require chemicals to be tested for their capacity to induce hypersensitivity. This type of testing has tr
We investigate the potential of different pre-fetching and/or caching strategies for different user behaviour with respect to surfing or browsing in a catch-up-TV network. To this end we identify accounts and channels associated with strong or weak surfing or browsing respectively and study the distributions of hold times for the different types of behaviour. Finally we present results from a requ
In whey ultrafiltration (UF) production, two main problems are whey protein recovery and membrane fouling. In this study, membrane coupling protein transglutaminase (TG) catalysis protein cross-linking was investigated under different conditions to find out the best treatment. We found that the optimal conditions for protein recovery involved catalyzing whey protein cross-linking with TG (40 U/g w
The aim of this study is to explore the links between modal options and opportunities to participate in everyday activities among people aged 65–79 and living in Sweden's large metropolitan regions (Stockholm, Gothenburg and Malmö). This incorporated a specific focus on those considered at a greater risk of transport-related social exclusion. This study applies the Capability Approach as a concept
OBJECTIVE: To examine the association between country of birth and hospitalization for pelvic inflammatory disease (PID), ectopic pregnancy (EP), endometriosis, and infertility.DESIGN: Follow-up study.SETTING: Sweden.PARTICIPANT(S): A total of 2,170,177 women living in Sweden at some point between 1990 and 2004, categorized into 10 different groups according to country of birth.INTERVENTION(S): No
New options are needed to reduce the impact of motor vehicles on climate change and declining fossil fuel resources. Cars which are fueled by hydrogen could be a sustainable method of transportation if suitable technologies can be devised to produce hydrogen in an environmentally benign manner along with the provision of the necessary fueling infrastructure. This paper assesses size, space, and co
The report examines the integrated Nordic power market and its linkages to renewable energy technology (RET) deployment for power production. It has two purposes. First, it aims to improve the understanding of the expansion of the Nordic power market and integration and deployment of RET. Secondly, it takes lessons from the Nordic experience that co
The efforts to develop a dopamine cell replacement therapy for Parkinson's disease have spanned over more than three decades. Based on almost 10 years of transplantation studies in animal models, the first patients receiving grafts of fetal-derived dopamine neuroblasts were operated in Lund in 1987. Over the following two decades, a total of 18 patients were transplanted and followed closely by ou
Obese patients are prone to arterial hypertension, require more antihypertensive medications, and have an increased risk of treatment-resistant arterial hypertension. Obesity-induced neurohumoral activation appears to be involved. The association between obesity and hypertension shows large inter-individual variability, likely through genetic mechanisms. Obesity affects overall cardiovascular and
