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This study develops the method for solution of inverse heat conduction problem applied to metal cutting. The proposed method operates with a selection procedure involving iterative solutions of heat forward problem. In such formulation, it allows avoiding difficulties associated with ill-posed inverse problems inherent to conventional formulations. Inverse heat problem was transformed into constra
Background: The ABILHAND questionnaire is recommended to assess perceived manual ability after stroke; however, more knowledge on interpretability is needed to improve the clinical applicability. Objectives: To determine clinically meaningful cutoff scores for different levels of perceived manual ability, assessed by ABILHAND, corresponding to established observed and perceived upper extremity ass
To promote sustainable manufacturing and lower industrial emissions, GE HealthCare is constantly assessing new approaches to improve their production processes. As a global manufacturer of contrast media, their potential for positive societal impact is significant. In addition to sustainability, a pharmaceutical production process is required to deliver products of high purity. This means that the
Next-generation sequencing (NGS) has transformed the study of antibody repertoires by enabling high-throughput, in-depth analysis of immune diversity and antigen-driven selection. When paired with in vitro display technologies, NGS offers unparalleled resolution in characterizing antibody libraries, but also presents substantial computational challenges due to the highly variable nature of antibod
The Million Homes Programme, launched in Sweden during the 1960s, resulted in the construction of over one million homes to address a national housing shortage. A majority of the houses consist of linear block buildings, many of which now require renovation. Moreover, climate change and increasing energy demands have put pressure on the building sector to reduce emissions and improve energy perfor
Fire safety design for complex buildings often relies on the Performance-based Design approach which assesses the margin of safety by comparing Available Safe Egress Time with Required Safe Egress Time. However, most current modelling tools often operate independently or at most with one-way coupling. This potentially reduces the accuracy of fire safety assessments by failing to capture dynamic in
This thesis was developed in partnership with SCM Group, a leading Italian manufacturer of material-cutting machinery operating an extensive international network of production sites and clients. Because of the magnitude of its operations, SCM’s technical support teams manage a large volume of support tickets-records submitted by clients on a daily bases: structured reports documenting machine fai
Metasurfaces are two-dimensional arrays of sub-wavelength structures often arranged in a periodic lattice. During recent years, metasurfaces have emerged as one of the most promising platforms to shape electromagnetic waves using compact devices, exhibiting extraordinary control over the light amplitude, polarization and phase. Starting with metallic materials, metasurface research has shifted tow
The rapid expansion of the plant-based beverage sector has increased the demand for high-performance, barista-grade oat drinks that are capable of withstanding the thermal and acidic stresses of coffee applications. This master’s thesis, conducted in collaboration with Cerealiq AB, evaluates the efficacy of six specific enzymatic treatments in modifying the structural and physical properties of oa
Peptide therapeutics offer advantages in specificity and affinity, yet the potential propensity to self-associate and aggregate poses a challenge for the development of stable oral formulations. This master’s thesis evaluates the utility of the fluorescent dye Thioflavin T as a structural probe to monitor the aggregation of glucagon-like peptide-1 receptor agonists, specifically Liraglutide and Se
Urban pluvial flooding threatens transport accessibility, yet the spatial factors such as elevation, vegetation, and road density associated with accessibility loss remain insufficiently understood. This study assessed changes in nearest-facility travel time to hospitals, clinics, schools, supermarkets, and fire stations under a 100-year return period flood scenario in Stockholm, Sweden, for both
Reliable ankle torque measurements are important in rehabilitation, where strength assessments are used to evaluate recovery and guide treatment. Isokinetic dynamometers, such as the Biodex system, are commonly used to provide controlled measurements of joint torque. However, these measurements rely on the ankle being held in a stable and reproducible position. Mechanical play in the ankle-attachm
As we become increasingly conscious of the entangled nature of human existence, we need to become more attuned to the needs of other species, and things on this planet we are bound to. This presents us with an opportunity to rethink in whose interest we approach architectural design, and to bring vital voices into the process that have – until now – been unable to make themselves heard. We conduct
AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab
The world has encountered numerous global crises, including epidemics, military conflicts, and economic collapse. Innovative digital technologies, such as Industry 4.0 (I4.0), can undoubtedly help improve industries’ operations during critical times. The dairy industry has seen an increment in technological adoption in the last few years. Adopting cutting-edge technologies is regarded as more feas
Agri-food systems globally experience growing difficulties associated with losses after harvesting, irregular quality, and inefficient utilization of resources, particularly within fruit supply chain (FSC). Given the complicated structure in FSCs, it is critical to guarantee quality at all levels to sustain customer satisfaction and optimize the utilization of resources. Conventional inspections a
As the impact of climate change intensifies, there is an urge to adapt Swedish residential buildings with a special focus on improving their energy efficiency and resilience. In this study, adaptive strategies through Artificial Intelligence and Reinforcement Learning will be provided for the energy management of different Swedish residential buildings. The aim will be the optimization of energy u
Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameter
Lithium-ion batteries (LIBs), particularly Nickel-Cobalt-Aluminum (NCA) variants, are widely recognized as essential for applications such as electric vehicles, renewable energy storage, and portable electronics. The superior energy density, extended lifespan, and thermal stability of NCA batteries make them a preferred choice for demanding applications, including electric marine propulsion. In th
