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Objective Individuals with SLE commonly report chest pain or discomfort. We performed cardiovascular magnetic resonance (CMR) to differentiate coronary artery disease (CAD), coronary microvascular dysfunction (CMD), pericarditis and myocarditis in individuals with SLE who presented with chest symptoms. We also assessed the clinical utility of CMR. Methods Adults with SLE were included if reporting
Lake water storage variations on the Tibetan Plateau (TP) serve as crucial indicators of regional hydrological dynamics and climate changes, providing more comprehensive insights than discrete measurements of lake area or water level alone. While accurate bathymetric data is fundamental for quantifying lake water storage, conventional bathymetric surveys are often constrained by logistical challen
Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps
AIMS/HYPOTHESIS: The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the progression from stages 1 or 2 to stage 3 type 1 diabetes.METHODS: Using high-resolution DQA1 and DQB1 genotypes from 1216 participants in the Diabetes Prevention Trial-Type 1 and the Diabetes Prevention Trial, we applied hierarchically orga
Background: High-resolution computed tomography (HRCT) is dependent on detailed morphology in diagnostic assessment of interstitial lung diseases. Photon-counting CT (PCCT) enables improved resolution while reducing radiation. Purpose: To compare if the image quality, detailed morphology, and radiation dose in HRCT of the lung improves with PCCT compared to energy-integrated CT (EICT). Material an
Objective To estimate the prevalence of the curable sexually transmitted infections (STIs) Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and Treponema pallidum, to identify associated risk factors and to assess ciprofloxacin resistance in N. gonorrhoeae-positive specimens among female sex workers (FSWs) in Guinea-Bissau. Methods For this cross-sectional
Industrial biotechnology has been defined as the use and application of biotechnology for the sustainable processing and production of chemicals, materials and fuels. It makes use of biocatalysts such as microbial communities, whole-cell microorganisms or purified enzymes. Although biocatalysts are considered advantageous, since they operate under mild conditions regarding temperature and pH and e
It has recently been established in our group that amphiphilic block copolymers consisting of a hydrophilic and a hydrophobic part can self-assemble in the presence of selective solvents (“water” and “oil”) into a variety of different solution and lyotropic liquid crystalline microstructures. The effects of the “oil” type, hydrophilic block size and hydrophobic block type on the phase behavior and
Objectives: In bio-naïve patients with PsA initiating a TNF inhibitor (TNFi), we aimed to identify baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission (primary objective) and DAPSA28 moderate response at 6 months, as well as drug retention at 12 months across 13 European registries. Methods: Baseline demographic and clinical characteristics were retrieved and the
Context. Occultations are windows of opportunity to indirectly peek into the dayside atmosphere of exoplanets. High-precision transit events provide information on the spin-orbit alignment of exoplanets around fast-rotating hosts. Aims. We aim to precisely measure the planetary radius and geometric albedo of the ultra-hot Jupiter (UHJ) KELT-20 b along with the spin-orbit alignment of the system. M
Background: Vesico-ureteral reflux (VUR) is a common associated urological anomaly in anorectal malformation (ARM)-patients. High-grade VUR requires antibiotic prophylaxis to prevent urinary tract infections (UTI's), renal scarring and -failure. The exact prevalence of high-grade VUR in ARM patients is unknown. Hence, the aim of this study was determining the incidence of high-grade VUR in ARM-pat
Weight-related discussions during childhood may have long-lasting effects on children’s body image and well-being. However, little is known about how parents frame these discussions with children who have undergone treatment for obesity. Our study aimed to explore how parents perceive weight-related discussions, several years after their children started obesity treatment. This qualitative study i
Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Heal
Urban pluvial flooding threatens transport accessibility, yet the spatial factors such as elevation, vegetation, and road density associated with accessibility loss remain insufficiently understood. This study assessed changes in nearest-facility travel time to hospitals, clinics, schools, supermarkets, and fire stations under a 100-year return period flood scenario in Stockholm, Sweden, for both
Quantitative Adverse Outcome Pathways (qAOPs) can support next-generation risk assessment by integrating new approach methods (NAMs) for deriving points of departure. To be useful, a qAOP should be chemical-agnostic. However, existing qAOP studies often pool multichemical data without adequately addressing cross-chemical heterogeneity. Consequently, pathway relationships become obscured by heterog
Only 15% to 30% of product development projects require the development of new product concepts. This means that the majority of design projects are carried out within the embodiment design and detail design phases. However, the majority of the research studies on the mechanical engineering design process, or design process for short, have been focusing on the conceptual design phase. The embodime
Introduction For the future conservation, restoration and daily maintenance the need for developing non-destructive and in-situ investigations is vital. At Lund University in Sweden an interdisciplinary research project is being held aiming at, with the help of a mobile system of remote fluorescence lidar, survey and study the facades of historic monuments, and to develop the method and its applic
Background Treatment of relapsing-remitting multiple sclerosis with interferon beta is only partly effective, and new more effective and safe strategies are needed. Our aim was to assess the efficacy of oral methylprednisolone as an add-on therapy to subcutaneous interferon beta-1a to reduce the yearly relapse rate in patients with relapsing-remitting multiple sclerosis. Methods NORMIMS (NORdic tr
