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We study a scenario where a monitor is interested in the freshest possible update from a remote sensor. The monitor also seeks to minimize the number of updates that exceed a certain freshness threshold, beyond which, the information is deemed to be too old. Previous work has presented results for First Come First Served (FCFS) systems. However, it has been shown that Last Come First Served (LCFS)We study a scenario where a monitor is interested in the freshest possible update from a remote sensor. The monitor also seeks to minimize the number of updates that exceed a certain freshness threshold, beyond which, the information is deemed to be too old. Previous work has presented results for First Come First Served (FCFS) systems. However, it has been shown that Last Come First Served (LCFS)

Introduction Approximately 4–6% of patients treated with oral anticoagulants (OAC) will suffer from major hemorrhage or be in need of urgent surgery necessitating anticoagulant reversal therapy. Several new oral anticoagulants and reversal agents have been introduced that make it difficult for physicians to stay updated on the current evidence of reversal management. This study aims to review the

(Neuro)psychiatric diagnoses such as attention deficit hyperactivity disorder (ADHD) is a rapidly growing and globally increasing phenomenon, not least in different educational contexts such as in family and in school. Children and youths labelled as ADHD are challenging normative claims in terms of nurturing and education, whereas those labelled as ADHD are considered a (future) risk for society

In agro-ecosystems, environmental monitoring is fundamental to detect and survey changes related to land use change and management practices. Butterflies and moths have often been suggested as suitable indicators for monitoring environmental effects on biodiversity in farmlands. Here, we estimated the required sample size and monitoring effort necessary to run a Lepidoptera survey in European farm

Bedrock U has been used as a proxy for local indoor radon exposure. A preliminary assessment of cancer incidence rate in a cohort of 809,939 adult males living in 9 different Swedish counties in 1986 has been used to correlate the cumulative lung cancer and total cancer (excluding lung) incidence rates between 1986 and 2020, respectively with the municipality average value of bedrock U concentrati

Background: Opioid overdose related injury or death can be prevented by bystander naloxone administration. For naloxone to be present when and where overdoses occur, opioid prevention education and naloxone distribution (OPEND) must be established on a broad level. This is the 30-month follow-up of the first multi-site naloxone project in Sweden, implemented at 31 sites in the County of Skåne 2018

Air pollution is recognized as the most important environmental factor that adversely affects human and societal wellbeing. Due to rapid urbanization, air pollution levels are increasing in the Sub-Saharan region, but there is a shortage of air pollution monitoring. Hence, exposure data to use as a base for exposure modelling and health effect assessments is also lacking. In this study, low-cost s

PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.METHODS: We id

Filamentous fungi play a key role as decomposers in Earth’s nutrient cycles. In soils, substrates are heterogeneously distributed in microenvironments. Hence, individual hyphae of a mycelium may experience very different environmental conditions simultaneously. In the current work, we investigated how fungi cope with local environmental variations at single-cell level. We developed a method based

BACKGROUND: Triticum aestivum (wheat) is one of the world's oldest crops and has been used for >8000 years as a food crop in North Africa, West Asia and Europe. Today, wheat is one of the most important sources of grain for humans, and is cultivated on greater areas of land than any other crop. As the human population increases and soil salinity becomes more prevalent, there is increased pressure

[3H]arachidonic acid (20:4) and [14C]linoleic acid (18:2) were fed in a triolein emulsion to essential fatty acid-deficient (EFAD) rats and to age-matched controls. Tissues were analyzed for radioactivity of different lipid classes after 1, 2, and 4 h. As in earlier studies [Nilsson and Melin. Am. J. Physiol. 255 (Gastrointest. Liver Physiol. 19): G612-G618, 1988], control rats retained more [3H]2

Terbinafine is used for the treatment of several superficial fungal infections. In silico analyses and animal models suggest that terbinafine might have an anti-tumor effect. We aimed to explore whether subsequent administration of terbinafine might be associated with a lower mortality rate in patients with prostate cancer. We identified patients diagnosed with prostate cancer between July 2005 an

Electrical field stimulation (EFS) of the rabbit urethral lamina propria elicited a frequency‐dependent non‐adrenergic, non‐cholinergic (NANC) relaxation, which was abolished by NΩ–nitro‐L‐arginine (l‐NOARG). Ω‐Conotoxin GVIA, a selective blocker of N‐type voltage‐operated calcium channels (VOCCs), and Ω‐conotoxin MVIIC (blocker of N‐ and Q‐type VOCCs) inhibited the NANC relaxation, and the inhibi

The argument running through Sevilla-Buitrago’s analysis is that spatial planning as a form of expertise cannot be untethered from capitalist urbanization, but that planning also must be related to urban commons, conceptualized as the actually existing self-management of resources in opposition to capital. The book’s four case studies are used all in an argument contending that planning must ‘neutThe argument running through Sevilla-Buitrago’s analysis is that spatial planning as a form of expertise cannot be untethered from capitalist urbanization, but that planning also must be related to urban commons, conceptualized as the actually existing self-management of resources in opposition to capital. The book’s four case studies are used all in an argument contending that planning must ‘neut

Per- and polyfluorinated alkyl substances (PFAS) are chemicals that have gained attention during the last years. There are about 10,000 different PFAS compounds, and due to their unique chemical characteristics, PFAS has been used in a variety of industrial applications and household products since the 1950s. Today, concerns about their toxicity and persistence have led to the regulation and banni

Elastic turbulence has emerged as a promising method to enhance heat transfer performance at the microscale. However, previous studies have mainly focused on the overall convective heat transfer performance in curved channels, overlooking the fact that the chaotic flow intensity varies along the streamline, leading to diverse local heat transfer characteristics. In this study, we systematically in

Current evidence on congenital malformations in the offspring of cancer survivors is largely inconsistent. Therefore, through this study we aimed to explore the prevalence of congenital malformations in the offspring of cancer survivors. To this end, female cancer survivors were identified from the Swedish Cancer Register and were further linked to the Swedish Medical Birth Register and Hospital D

A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, t

BACKGROUND & AIMS: Phosphodiesterase 5 (PDE5) inhibitors have been proposed to have chemopreventative effects on colorectal cancer (CRC), although data are needed from population-based studies. We performed a nationwide cohort study to investigate the association between use of PDE5 inhibitors and risk of CRC in men with benign colorectal neoplasms.METHODS: We identified men who received a dia

Mycosis fungoides is a disease with manifestation of the skin that has traditionally been treated with electron therapy. In this paper, we present a method of treating the entire skin with megavoltage photons using helical tomotherapy (HT), verified through a phantom study and clinical dosimetric data from our first two treated patients. A whole body phantom was fitted with a wetsuit as bolus, and