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The presence of different time scales in a dynamic model significantly hampers the efficiency of its simulation. In multibody systems the fact is particularly relevant, as the mentioned time scales may be very different, due for example to the coexistence of mechanical components controlled by electronic drive units, and may also appear in conjunction with significant nonlinearities. This paper pr
Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in its early stages prior to the formation of amyloid plaques and the occurrence of irreversible neuronal damage. Since oligomeric A beta species have been implicated in the pathophysiology of AD, we reasoned
Objectives: We evaluated a method for gas monitoring in the mastoid cavity using tunable diode laser spectroscopy by comparing it to simultaneously obtained computed tomographic (CT) scans. Methods: The presented optical technique measures free gases, oxygen (O2), and water vapor (H2O) within human tissue by use of low-power diode lasers. Laser light was sent into the tip of the mastoid process
It is frequently observed that the local relative abundances of aquatic microbial taxa are correlated with their average relative abundance at the regional scale, which results in the composition of different communities being more similar than expected by chance or invariant. The degree to which communities within a region match the regional average community is variable and likely depends on sev
This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. A consistent increase before the late 1990s and a dramatic decrease afterwards were observed for CUP incidence among Swedes,re
In this paper we first critically review conventional environmental economics. We conclude that the standard theory offers too narrow a perspective for many real world problems and that many theories are not empirically tested. Consequently, environmental economics is at risk of producing aeroplanes without engines. Next, we welcome and discuss some recent trends, particularly the rapid developmen
The emergence of post-genomic approaches that couple chromatin immunoprecipitation (ChIP) assays to high-throughput technique has greatly advanced our ability to investigate epigenetic features associated with normal cell development and disease. Nevertheless, these techniques exhibit some limitations. Firstly, standard protocols usually require millions of cells, thus limiting their application t
Substituting Zn for Cu is known to rapidly quench superconductivity in the doped perovskites but the mechanism behind it is still not clearly understood. Single phase YBa2(Cu1-xZnx)(3)O7-delta (x=0.0 to 0.06) samples were synthesized and characterized using XRD, wet titration, resistivity, and ac susceptibility. Angle-integrated Valence Band Photo emission and Zn K-edge XAFS results clearly show t
We focus on exclusive production of neutral technipion (pi) over tilde (0) in pp collisions at the LHC, i.e. on pp -> pp (pi) over tilde (0) reaction. The dependence of the cross section on parameters of recently proposed vector-like Technicolor model is studied. Characteristic features of the differential distributions are discussed. For not too large technipion masses the diphoton decay channel
BACKGROUND: For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI g
The Cone Calorimeter test method has been one of the most used small-scale fire test method for years now and is at present widely spread over the world. In contrast to many other fire test methods, the Cone Calorimeter provides a range of data with sound scientific basis, which allows a wide range of applications. It can be used for modelling and also for enhanced product development. This paper
Background: Observational studies have consistently associated obesity with colorectal cancer risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer. Methods: We conducted a comprehensive population-based case-control study in 1,792 German colorectal c
Objective. This study aimed to survey current Swedish practices for performing and handling transrectal ultrasound-guided prostate biopsies. Material and methods. A Swedish Urology Network (SUNe) was organized for the distribution of information, survey studies and research collaborations. A web-based questionnaire was distributed to the members in 2011. Results. In this first SUNe survey, 137 (91
In this thesis we consider different tests for unit roots in the presence of structural change. We present the theory that lies behind unit roots, what we mean by structural change and try to detect the instances that “breaks” occur in the data. When performing a unit root test, when there is a structural change the results are biased toward accepting a unit root. Therefore, special care must be t
The main sustainability goal of many small islands in the North Sea is to become self supplied in renewable energy in 20-30 years. The majority of the islands are trying to repeat Samsø‘s success – to make a transition towards energy sustainable system by new energy production from local renewable sources such as wind, solar and biomass. However, for other islands like Spiekeroog island, a tourist
In an era of globalization, international legal frameworks and vigorous international politics, we cannot refrain from hearing about the extensive health crisis of the developing world. HIV/AIDS, Malaria and drug resistant tuberculosis are only a few of the widespread disease which appear almost surreal to the citizens of the industrial world. The debates and discussions regarding the importance o
Vessel-source pollution is regarded as one of the major sources that harm marine environment. It has become an issue of public concern since 20th century due to a series of oil pollution incidents on the sea. Fortunately, international law has been developed to control this source of pollution taking consideration of the importance of protection and preservation of marine environment and sustainab
