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The composition of cultivation media in relation to strain development for industrial application is reviewed. Heterologous protein production and pentose utilization by Saccharomyces cerevisiae are used to illustrate the influence of media composition at different stages of strain construction and strain development. The effects of complex, defined and industrial media are compared. Auxotrophic s
Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical setting it is difficult to directly evaluate the effects of antiarrhythmic drugs on
In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's disease. The mechanisms underlying these involuntary movements need to be clarified before this approach to clinical cell therapy can be developed further. We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that hav
Despite the spatially homogenous summer temperaturepattern in Fennoscandia, there are large spreadsamong the many existing reconstructions, resulting in anuncertainty in the timing and amplitude of past changes.Also, there has been a general bias towards northernmostFennoscandia. In an attempt to provide a more spatiallycoherent view of summer (June–August, JJA) temperaturevariability within the l
Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. Patologiska förändringar i olika delar av basala ganglierna orsakar många av de symptom som kännetecknar Huntington's och ParHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou
It is shown that under certain regularity conditions on the norm, the functions in a nontrivial invariant subspace of the backward shift operator have meromorphic pseudocontinuations in the Nevanlinna class of the exterior of the unit disk. In addition, we provide a regularity condition which implies that the subspace itself is contained in the Nevanlinna class of the disc.
Popular Abstract in Swedish Magnetresonanstomografi (MRT) är en metod för framställning av bilder av kroppen och av sjukliga förändringar i kroppen. När metoden introducerades ansågs den utomordentligt goda inbyggda vävnadskontrasten vara tillräcklig för att särskilja olika sjukliga förändringar, speciellt i hjärnan. Det har emellertid visat sig att förmågan att upptäcka sjukliga förändringar är oAims of the study The aims of this study using Gadodiamide injection were to investigate: · Whether Gadodiamide injection was comparable to Gd-DTPA for the enhancement of CNS lesions. · The contrast effect at different field strengths. · The effective time-window for the enhancement of blood-brain barrier damage. · The relations between the concentration of contrast agent and enhancement in p
Supportive legislation and improving technologies are making bioenergy an increasingly attractive energy source for Europe both economically and environmentally. However, abundant resources remain untapped across many member states in the European Union (EU). The Bioenergy Network of Excellence (NoE) entitled Overcoming Barriers to Bioenergy in Europe is charged with the task to identify critical
How can qualitative, ethnographic and emotional aspects from probe users be mapped at the same time as they get something meaningful in return? The emphasis is here on intellectual rewards during probe work rather than future good designs that in a long term perspective can be beneficial for the probe user. This case study has elaborated the traditional use of cultural probes [1] with a selection
Based on a case study of a telecom company’s transition towards more software value in their products, we describe and discuss SCM issues related to when traditional manufacturers go from a “hardware focus” to a mixed product configuration. Although software supply chain is not much discussed in logistics, it seems that logistics/SCM frameworks also fit many software supply issues. A specific soft
Quality requirements complement functional requirements with information on the target quality levels of software functions or emergent system quality aspects. In release planning the allocation of development effort in further investments into product enhancements, new or enhanced functions are competing with quality improvements for limited resources. When setting balanced quality targets for de
The Sixth Sense of PR-Experts? An Expert-Novice-Comparison of PR-Problem-Solving and Implications for Public Relations-Pedagogy
This thesis deals with tools for operational improvement of supply chain performance. The work was aimed at providing knowledge for supply chain developers and practitioners, and identifying and developing tools for improved performance in a supply chain. The investigation was part of a project financed by the European Commission called "Industrial Supply Chain Optimizer" (ISCO). The thesis consis
