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Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is linked with aggregation of α-synuclein protein. PD can be diagnosed using real-time quaking induced conversion (RT-QuIC) assay. RT-QuIC, despite its effectiveness, is not really understood in terms of the mechanisms driving it. Aim(s): The aim of the project was to reproduce RT-QuIC protocol develop
Let $\dim_H(\mathcal{J}_\epsilon)$ and $\dim_H(\mathcal{J}_{i\epsilon})$ denote the Hausdorff dimension of the Julia set of the polynomials $f_\epsilon(z) = z^2 -2 -\epsilon$ and $f_{i\epsilon}(z) = z^2 -2 +i\epsilon$ receptively for small $\epsilon>0$. This thesis contains two main Theorems, both dealing with the upper bound for the asymptotic behaviour of $\dim_H(\mathcal{J}_\epsilon)$ and $\dim
Abstract Purpose: This study investigates the impact of social influence on consumer preferences for product recommendations made by an AI or a human within the cosmetics industry, specifically in light of hedonic or utilitarian goals. Methodology: This quantitative research follows a deductive approach, using an online self-completion survey for data collection. A total of 659 valid responses w
Switzerland's current food system is unsustainable and responsible for 25% of the country's environmental footprint. Half of the greenhouse gas emissions from the Swiss food system are caused by meat and dairy consumption. Reducing Switzerland's GHG emissions from the food system requires an orchestrated approach, targeting amended consumption and production patterns. A primary change
In most manufacturing companies, it is necessary to carry inventory to a greater or lesser extent in order to disconnect the activities in the supply chain that are not conducted at the same pace. This way, a smoother flow through the chain, from raw material extraction to arrival at the final customer of a finished product, is facilitated. However, different parts of a company often have conflict
The studied intrusion, the Hakefjorden Complex on Älgön is a norite-anorthosite complex situated in the archipelago on the west coast of Sweden. The origin of the intrusion will be deduce through in situ Sr-isotope analysis by MC-ICP-MS (multiple collector- inductively coupled plasma- mass spectrometry) on plagioclase, together with petrographic description and chemical analysis. The examined plag
A grant back obligation refers to the obligation for a licensee to assign or license future developed improvements to a licensor. Grant back clauses affect on competition has been a controversial subject in economic and legal doctrine. The study answers if the changed approach in the European Union towards the separation of severable and nonseverable improvements in relation to grant back clauses
The purpose of this study is to examine whether an acquiring firm that operates as a contractor within the defence sector can expect to generate shareholder value from a merger and acquisition with a fellow defence sector competitor. Having selected thirty acquiring defence firms an event study utilizing the market model is performed to obtain the abnormal returns generated from a merger and acqui
The debt equity bias refers to the discrimination between debt and equity finance. This discrimination is problematic since it distorts companies’ decisions and increases systemic risk. The European Commission has recommended Sweden to eliminate or reduce the bias and the Swedish Ministry of Finance has gathered a committee to investigate possible solutions. Sørensen (2010) suggested that Sweden w
Large companies in today’s business environment are to a great extent depending on their credit score by rating institutes like Moody’s and Standard & Poor’s. There is however indications that these big institutes are not always rating companies accurately. This is why this thesis aims at developing a new credit rating model, CRITA-Score, with the objective of determining a company’s financial
Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. Moreover, drugs can bypass the blood-brain barrier and directly reach the brain through the olfactory route
This analytical essay critically examines how social sustainability is constructed within Lund’s municipality district development program for Norra Fäladen. The existing research widely acknowledges that sustainable development and social sustainability are characterized by conceptual ambiguity and a lack of consensus regarding definition and measurement. Despite this, they are leading concepts f
This study aims to examine the challenges and practices of staff working at accommodations regulated by the Swedish Act concerning support and service for persons with certain functional impairments (LSS) when working with women with disabilities who have suffered from violence. Previous research shows that women with disabilities are at a greater risk of being victims of violence. Despite this kn
Winter is a critical bottleneck period for many insects and is particularly pivotal for pest species, being a major regulator of their populations. In winter, insect fruit pests such as the invasive fly, Drosophila suzukii, not only have to cope with harsh environmental conditions but also need to find alternative resources when cultivated fruit are scarce. This study aimed to disentangle the rela
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Context. Despite the ever-increasing number of known exoplanets, no uncontested detections have been made of their satellites, known as exomoons. Aims. The quest to find exomoons is at the forefront of exoplanetary sciences. Certain space-born instruments are thought to be suitable for this purpose. We show the progress made with the CHaracterising ExOPlanets Satellite (CHEOPS) in this field using
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
Building materials account for a high percentage of the non-land cost of self-help housing. Few studies, however, have examined the use of building materials by self-help builders and the practicalities of producing and distributing the materials in an alternative manner. This paper discusses the nature of construction by self-help in the intermediate-sized Colombian city of Pereira, focusing in p
The current framing of AI-driven technologies situates them as solutions to a looming care crisis. However, this overlooks informal caregivers' key role to current State budgetary deficits impacting healthcare services happening in Europe. As States increasingly rely on informal caregivers to provide care before the necessary involvement of healthcare services, there is already well-established re
