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The ongoing globalisation and the rise of the knowledge economy creates new challenges for regional economic development. In order to cope with these challenges, regions need to strengthen the capacity of existing industries to innovate, but also transform their innovation systems and facilitate the emergence of new industries and development paths. The ability to transform and renew themselves, h
Popular Abstract in Swedish När vi äter ökar nivån av blodsocker (blodglukos) i blodet. Glukos forslas i blodet till målvävnader, såsom fett och skelettmuskel, där det används som energi. Men för att glukos ska kunna tas upp av målvävnaden krävs insulin. Insulin är ett hormon som produceras av beta-celler i bukspottkörtelns Langerhanska öar, vars sekretion ut i blodet regleras av blodglukos. Då deType 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocytotic process is crucial for beta cell function and its dysregulation leads to impai
The oxidation of biogenic volatile organic compounds (BVOCs) gives a range of products, from semi-volatile to extremely low-volatility compounds. To treat the interaction of these secondary organic vapours with the particle phase, global aerosol microphysics models generally use either a thermodynamic partitioning approach (assuming instant equilibrium between semi-volatile oxidation products and
The prototypical antimicrobial peptide, melittin, is well-known for its ability to induce pores in zwitterionic model lipid membranes. However, the mechanism by which melittin accomplishes this is not fully understood. We have conducted all-atom and coarse-grained molecular dynamics simulations which suggest that melittin employs a highly cooperative mechanism for the induction of both small and l
Nitrous oxide, carbon dioxide and methane are greenhouse gases (GHG) emitted from wastewater treatment that contribute to its carbon footprint. As a result of the increasing awareness of GHG emissions from wastewater treatment plants (WWTPs), new modelling, design, and operational tools have been developed to address and reduce GHG emissions at the plant-wide scale and beyond. This paper reviews t
The objective of this work is to establish under which conditions short RNA molecules (similar to miRNA) associate with zwitterionic phospholipids and how this differs from the association with cationic surfactants. We study how the base pairing (i.e., single stranded versus double stranded nucleic acids) and the length of the nucleic acid and the charge of the lipid/surfactant monolayer affect th
Purpose of this paper The purpose of this paper is to present a comparative case study of the procedures and guiding principles in the packaging selection practice of two international companies. Design/methodology/approach A qualitative case study with an inductive approach was conducted. The data was collected through semi-structured interviews, documentation, and field visits. Findings Th
Stylistic Fronting (SF) is a process that fronts various types of non-subjects to the preverbal position in subjectless clauses (“that gone have”, etc.). With the exception of Icelandic and to some extent Faroese, SF has disappeared from Scandinavian varieties. It is commonly assumed that even in Icelandic it is formal and old fashioned, indicating that it might be on its way out of this language
Popular Abstract in Swedish Jag har i den här avhandlingen behandlat problemställningar inom tre olika områden inom astronomin. Det som sammanlänkar dessa är att alla innefattar dubbelstjärnor där avståndet mellan stjärnorna är litet, dvs de har en kort period. De är också alla datorsimuleringar. Jag har satt upp en modell för att betrakta de astronomiska systemen och genom numeriska metoder beräkThis thesis introduces and summarizes four papers dealing with computer simulations of astrophysical processes involving binaries. The first part gives the rational and theoretical background to these papers. In paper I and II a statistical approach to studying eclipsing binaries is described. By using population synthesis models for binaries the probabilities for eclipses are calculated for diff
The resistivity method is an established geophysical method with a broad range of engineering and environmental applications. It has been tried numerous times on embankment dams, mainly for seepage investigations, dam status control and investigations of known defects. In previous use of the method on embankment dams some success has been reported, but only occasionally. The method is still not co
Popular Abstract in English This dissertation attempts to answer the question of why the 2003 armed conflict against Iraq received such varied support within the United States, the United Kingdom, Australia, France and Spain. This is achieved by introducing a model in which the support for armed conflict is connected to elite persuasion operating in particular contexts. This model is tested in a cThis dissertation attempts to answer the question of why the 2003 armed conflict against Iraq received such varied support within the United States, the United Kingdom, Australia, France and Spain. This is achieved by introducing a model in which the support for armed conflict is connected to elite persuasion operating in particular contexts. This model is tested in a comparative study, using inte
Abstract in UndeterminedCompanies in the food industry are driven to improve their traceability for several reasons. The primary reasons are food safety and quality. Another is the response to the increased interest among consumers in imperceptible product attributes such as organic, fair trade, dolphin-safe and non genetically modified (non-GMO). Such attributes are hard to distinguish and thus r
Background: Symptoms associated with primary headaches are linked to cranial vascular activity and to the central nervous system (CNS). Review: The central projections of sensory nerves from three cranial vessels are described in order to further understand pain mechanisms involved in primary headaches. Tracers that label small and large calibre primary afferent fibres revealed similar distributio
PURPOSE: Urinary proteomics has become a key discipline within clinical proteomics for noninvasive diagnosis and monitoring of disease, and biomarker discovery. In order to decipher complex proteomes, high demands will, however, be placed upon the methodology applied. The purpose of this study was to develop a recombinant antibody microarray platform for urinary proteomics. EXPERIMENTAL DESIGN: W
Soil is a dynamic system in which microorganisms perform important tasks in organic matter transformations and nutrient cycles. Recently, some studies have started to focus on soil metaproteomics as a tool for understanding the function and the role of members of the microbial community. The aim of our work was to provide a review of soil proteomics by looking at the methodologies used in order to
A common way to cool the tip is to use serpentine passages with 180-deg turn under the blade tip-cap. Improving internal convective cooling is therefore required to increase the blade tip life. In this paper, augmented heat transfer of a blade tip has been investigated numerically. The computational models consist of a two-pass channel with 180-deg turn and pin-fins mounted on the tip-cap, and a s
Digital volume correlation analysis of time-resolved X-ray microtomography scans acquired during in situ triaxial compression of Green River shale cores provided time series of 3-D incremental strain fields that elucidated evolving deformation processes by quantifying microscopic strain localization. With these data, we investigated the impact of mechanical anisotropy on microscopic strain localiz
Software Engineering activities are information intensive. Research proposes Information Retrieval (IR) techniques to support engineers in their daily tasks, such as establishing and maintaining traceability links, fault identification, and software maintenance. We describe an engineering task, test case selection, and illustrate our problem analysis and solution discovery process. The objective o
The molecular weight distribution and the viscosity of water-soluble polysaccharides isolated from carrots were investigated after different types of heat-treatment, commonly used when preparing food. The materials studied were blanched, boiled, microwaved and canned. Freezing, without any heat-treatment, was used as a reference process. The water soluble polysaccharides were isolated using two di
