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Recombinant DNA technology has made it possible to produce specific Fab and scFv antibody (Ab) fragments in prokaryotic host cells. Using vectors designed for periplasmic expression of encoded Ab fragments, we have been studying how the sequence and genetic localization of the light chain (L-chain) variable region gene of a mouse Ab (CB-Nm.1) determined the level of Ab production. The variable reg
Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in
Retinoic acid (RA) is an important morphogen that regulates many biological processes, including the development of the central nervous system (CNS). Its synthesis from vitamin A (retinol) occurs in two steps, with the second reaction - catalyzed by retinal dehydrogenases (RALDHs) - long considered to be crucial for tissue-specific RA production in the embryo. We have recently identified the Xenop
We have previously proposed the use of Doppler ultrasound to non-invasively stage sinus infection, as we showed that acoustic streaming could be generated in nonpurulent sinus secretions and helped to distinguish it from mucopurulent sinus secretions. In order to continue this development of a clinically applicable Doppler equipment, we need to determine different dimensions of the paranasal sinus
To ascertain the epigenomic features, i.e., the methylation, non-coding RNA, and gene expression patterns, associated with gain of i(12p) in Pallister-Killian syndrome (PKS), we investigated single cell clones, harboring either disomy 12 or tetrasomy 12p, from a patient with PKS. The i(12p)-positive cells displayed a characteristic expression and methylation signature. Of all the genes on 12p, 13%
The Transient Receptor Potential, TRP, family is a group of non-selective ion channels which can be activated by harmful stimuli such as temperature, chemicals and mechanical stimuli. The channels play a crucial role in many physiological processes and it is therefore of great interest to know more about these proteins. The TRPA1 is one of many TRP channels, and a better knowledge of its function
Forskningsfrågor: Är tidigare studiers förklaringsmodeller för fastighetsföretags kapitalstruktur applicerbara på den svenska marknaden? Hur påverkar kapitalstrukturen hos svenska fastighetsbolag deras lönsamhet över en period av ränteförändringar? Syfte: Studiens syfte är att undersöka om de förklaringsmodeller för fastighetsföretags kapitalstruktur som presenteras i tidigare studier även kan appResearch questions: Are previous studies’ explanatory models for real estate companies’ capital structure applicable on the Swedish market? How does the capital structure of Swedish real estate companies affect their profitability over a period of interest rate chnages? Purpose: The purpose of this study is to examine whether the explanatory models for the capital structure of real estate companie
Forskningsfråga: Skiljer sig kapitalstrukturen mellan familjeföretag och icke-familjeföretag? Syfte: Studiens syfte är att undersöka om det finns en skillnad i kapitalstruktur mellan familjeföretag och icke-familjeföretag noterade på börsen i Sverige. Utöver det undersöks hur företagsspecifika variabler, som exempelvis storlek, bransch och lönsamhet, påverkar företagens skuldsättningsgrad. MetodResearch Question: Does the capital structure differ between family-owned and non-family-owned businesses? Purpose: The purpose of this study is to investigate whether there is a difference in capital structure between family-owned and non-family-owned companies listed on the Swedish stock market. Additionally, the study examines how firm-specific variables, such as size, industry, and profitabil
Malaysia is one of the most developed countries in Southeast Asia, and strives to be acknowledged as a high income country by the year of 2020. According to Malaysian Environmental Quality (Sewage) Regulations from 2009 there are effluent limitations regarding nutrient emission from wastewater treatment plants. The company responsible for the municipal wastewater treatment, Indah Water Konsortium,
In this project a two Higgs doublet model with a complex singlet and an extra family symmetry providing a mechanism for suppression of flavor changing neutral currents is explored. The goal is to investigate the phenomenological consistency of the model using a custom software framework. To this end, the scalar and Yukawa sectors of this extension of the Standard Model are explored in detail. The
Sweden has in the past decade embarked on a journey to rebuild the concept of ‘total defence’. The crisis management system led by the Swedish Civil Contingency Agency has become all-the-more involved in the civil defense, with the Swedish Armed Forces responsible for military defense. The present thesis aims to explore the topic of gender and language in Sweden’s total defense discourse to uncove
AI-Assisted and Semi-Autonomous tools are becoming relevant for enterprises. The adoption of these tools requires understanding how different practitioners perceive and use them responsibly in their organizations. This thesis examines how enterprise software development practitioners govern AI-assisted and semi-autonomous tools in everyday development workflows. As these tools increasingly support
Title: Lean Product Development - The Bank of Tomorrow? Seminar date: June 1st, 2012 Course: Master thesis in business administration, 30 University Credit Points (30 ECTS). Authors: Åsa David and Madeleine Göransson Advisor: Gert Paulsson Key words: Lean, Lean Innovation, Lean Product Development, Return on Investment, Engineering Industry Aim: The aim of the study is to describe and analyze how
Title: To make a living by library music; Opportunities and prerequisites. The purpose of this essay is to investigate how a music producer or composer can achieve placement of his or her music in commercials, TV-shows, computer games, and other media. What is required to make a living by composing and producing music today? This is a qualitative study made by interviewing six persons, who all in
Acute postoperative pain remains a major clinical challenge, affecting both recovery and resource utilisation. Beyond nociceptive input, pain is shaped by cognitive and emotional factors, including patient expectations. This narrative review examines the role of expectations in perioperative pain modulation, framed within predictive coding and Bayesian inference models. These models conceptualise
This case study investigates the development of subject-specific literacy in Physical Education and Health (PEH) for second language (L2) learners within a Swedish secondary school context. Integrating Systemic Functional Linguistics (SFL) and Legitimation Code Theory (LCT), the study introduces the concept of embodied cohesion to analyze how meaning is constructed across verbal, graphic, and phys
Nature-based Solutions (NBS) are recognized as key actions for achieving sustainable and resilient development. They are being implemented in a variety of fields, such as urban planning, and offer a wide range of social, environmental, and economic benefits. While there has been a significant increase in the number of NBS practices in recent years, there remains a notable imbalance, with a bias to
Automotive brake rotors are commonly made from gray cast iron (GCI). During usage, brake rotors are gradually worn off and periodically replaced. Currently, replaced brake rotors are mostly remelted to produce brand-new cast iron products, resulting in a relatively high energy consumption and carbon footprint into the environment. In addition, automotive brakes emit airborne particles. Some of the
Line segments are ubiquitous in our human-made world and are increasingly used in vision tasks. They are complementary to feature points thanks to their spatial extent and the structural information they provide. Traditional line detectors based on the image gradient are extremely fast and accurate, but lack robustness in noisy images and challenging conditions. Their learned counterparts are more
Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without di
