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Cell death is an important field of biology that is linked to many other topics in medicine and biology. One of the methods to investigate cell death is through high content screening (HCS) which makes use of robotic microscopy. By this technology, cell death associated organelle membrane permeabilisation and the localisation of certain dyes can be visualised and elucidate a substantial amount of
Technological advancements continue to drive changes in our modern society. To keep up with these changes, it is of utter importance to stay competitive, whilst remaining flexible enough to be prepared for future changes. A sector which has struggled in this aspect, traditionally, is self-employed craftsmen - individuals who run a business based upon an aptitude for their trade. This study focuses
This thesis is based on an ethnographic research on the role of health and public health care in neighborhood pubs in Helsinki. The goal was to understand why potential customers of the public health care services do not utilize the services offered. Based on the new understanding generated, a pilot health care service was developed in cooperation with two pubs, municipal health care, and the nurs
The RAINBOW program, a Child and Family-Focused Cognitive Behavioral Therapy program (CFF-CBT) for Pediatric Bipolar Disorder (PBD) designed for children aged 8-12 years and their parents, in a parallel group format, has been adapted to adolescents aged 14-17. The aim of this study was to investigate if CFF-CBT is effective and feasible for adolescents and their parents in Sweden. Method: The samp
Several standardized assessment instruments have been introduced in social work in the last ten years. One of them, the Addiction Severity Index (ASI), is used today in the Swedish social services, and in the Prison and probation services. Swedish state authorities make strong declarations to implement the ASI-interview while critics are sceptic to both its practical relevance and epistemological
A search for high-mass resonances decaying into tau(+)tau(-) final states using proton-proton collisions at root s = 8 TeV produced by the Large Hadron Collider is presented. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 19.5-20.3 fb(-1). No statistically significant excess above the Standard Model expectation is observed; 95% credibility upper limits
Evidence-based software engineering (EBSE) aims to improve research utilization in practice. It relies on systematic methods (like systematic literature reviews, systematic mapping studies, and rapid reviews) to identify, appraise, and synthesize existing research findings to answer questions of interest. However, the lack of practitioners' involvement in the design, execution, and reporting of th
Maternal intrauterine enterovirus infection during pregnancy increases the risk for the offspring to develop type 1 diabetes mellitus. Type 1 diabetes mellitus and autoimmune thyroiditits (AIT) are closely linked. A common pathogenetic factor is possible. The objective of this study was to investigate a possible association between maternal enterovirus infection during pregnancy and the developmen
Creating efficient public transport systems that attract users is a challenging task in contexts where the control of public transport is divided between various actors. Recent research on public transport has therefore seen increasing focus on issues like coordination, collaboration and steering in complex governance settings. However, more is known about what needs to be done than how to impleme
Purpose: Head trauma is a common complaint in emergency departments. Identifying patients with serious injuries can be difficult and generates many computerized tomographies. Reducing the number of computerized tomographies decreases both cost and radiation exposure. The aim of this study was to evaluate whether the current Scandinavian Neurotrauma Committee guidelines could be revised in such a w
Brown macroalgae (Phaeophyta) hold high potential as feedstock for biorefineries due to high biomass productivity and carbohydrate content. They are, however, a challenging, unconventional feedstock for microbial refining and several processing problems need to be solved to make them a viable option. Pre-treatment is necessary to enhance accessibility and solubility of the biomass components but s
Storage of greywater is controversial for environmental and health reasons. Artificial greywater was assessed after 2 and 7 days of storage time. Two different greywater pollutant strengths were statistically compared at each storage time. A negative significant (p < 0.05) correlation was evident with increasing storage time for the 5-day biochemical oxygen demand for more than 2 days. However, th
Context. The study of the Milky Way relies on our ability to interpret the light from stars correctly. With the advent of the astrometric ESA mission Gaia we will enter a new era where the study of the Milky Way can be undertaken on much larger scales than currently possible. In particular we will be able to obtain full 3D space motions of red giant stars at large distances. This calls for a reinv
Background: Occurrence of severe asthma exacerbations are the cornerstone of the evaluation of asthma management, but severe asthma exacerbations are rare events. Therefore, trials that assess drug efficacy on exacerbations are done late in clinical development programmes. We aimed to establish an endpoint capturing clinically relevant deteriorations (diary events) that, when combined with severe
