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One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expre
Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride
Species’ range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiv
Denna studie redovisar resultaten av en universitetskurs som syftar till att utforska och förbättra samarbetet inom vården med både canceröverlevare, anhöriga och vårdpersonal som studenter.Centralt i kursen var förståelsen för och att röra sig mellan varandras perspektiv. Genom att arbeta inom ramar inspirerade av problembaserat lärande (PBL), skapade små grupper bestående av minst en canceröverlThis study reports the results of a university course aimed at exploring and improving cooperation in healthcare with both cancer survivors, loved ones and healthcare professionals as students.Central to the course was the understanding of and moving between each other's perspectives. Operating within a framework inspired by problem-based learning (PBL), small groups consisting of at least one can
BACKGROUND: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer. METHODS: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnose
Kulturartikel om EU:s bestämmelser om terroristbrott, med avseende på sociala rörelser och demokrati.
Breast cancer is the most common cancer in women worldwide, identification of new biomarkers for early diagnosis and detection will improve the clinical outcome of breast cancer patients. In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assay
Årets Arena Idé-rapport om den svenska modellen och organisations-graden hos fack, arbetsgivare och a-kassor innehåller de senaste medlemsuppgifterna för samtliga fackförbund inklusive förbunden utanför LO, TCO och Saco. Det gäller antalet yrkesaktiva medlemmar vid årsskiftet 2024/2025. Även medlemsutvecklingen i PTK och OFR redovisas avseende de medlemmar som räknas till respektive förhandlingsor
U ranijim istraživanjima ratnog nasilja, tokom rata u Bosni i Hercegovini, naglašavana je važnost priča ŽRTAVA ali fokus analize nije bio usmjeren na priče o ratnom nasilju, niti su analizirani poslijeratni intervjui kao produkt međuljudske interakcije. Ovom studijom pokušava se popuniti ta praznina analiziranjem priča osoba koje su preživjele rat u sjeverozapadnoj Bosni i Hercegovini. Prvi cilj s
Mental health disorders are a rapidly growing public health problem. Despite the fact that lack of trust in the health-care system is considered to be an important determinant of health, there is scarcity of empirical evidence demonstrating its associations with health outcomes. This is the first study which aims to evaluate the association between trust in the health-care system and psychological
Recent advances in the digital detector technology have paved the way for modalities such as two-dimensional digital mammography (DM) and three-dimensional breast tomosynthesis (BT). In this work, experimental studies were conducted to investigate the influence of reducing the average glandular dose (AGD) on detection of simulated lesions in DM and to compare the diagnostic accuracy of BT and DM.
Fire is a pivotal aspect of human involvement in the carbon cycle. However, the precise timing of the large-scale human fire use remains uncertain. Here, we report a pyrogenic carbon record of East Asian fire history over the past 300,000 y from the East China Sea. This record suggests a rapid increase in fire activity since approximately 50,000 y ago, indicating a decoupling from the monsoon clim
INTRODUCTIONThis study examines medication reviews (MRs) among people living with dementia (PWD) in Sweden, focusing on frequency and factors influencing access.METHODSUsing nationwide register data, all diagnosed PWD from 2010 to 2016 were assessed for MR receipt in 2015 and/or 2016. The analysis guided by the Andersen healthcare utilization framework, considered predisposing, enabling, and need-
In this thesis the relation between the everyday meal, the doings of family and the reproduction of difference in Swedish everyday family life is explored. The thesis has a qualitative approach and interviews with parents from different class and ethnic backgrounds and family constellations, but all with children under the age of 8 years old, is the empirical basis. Using sociological and feminist
The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. An important tool in detecting and studying bnAbs, are neutralization assays. Here we d
The deinstitutionalization of mental health care has changed the responsibilities of involved authoritiesand has led to a continuous need for new treatment forms and interventions. This articledescribes this development in Europe, and in particular how these new conditions have been handledin Sweden over the past 20 years at the level of governmental policy-making. Three major policydocuments from
Popular Abstract in Swedish Komplementsystemet utgör en del av den medfödda immuniteten och är viktigt i försvaret mot angripande mikroorganismer. Ärftlig C2-brist (C2D) är en av de vanligaste bristerna inom komplementsystemet och förekommer i en frekvens av 1: 20 000 hos personer med västerländsk härstamning. I de aktuella undersökningarna har mer än 40 personer med C2D identifierats och observerThe complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. In the present investigation, the identification of more than 40 C2D persons at a single centre combined with long observation peri
Syftet med denna studie är att utifrån mitt empiriska material kartlägga och beskriva hur de anställda på de särskilda ungdomshemmen tolkar, definierar, och upplever ett behandlingsprojekt, som involverade olika myndigheter, benämnt Motverka Våld och Gäng. Dessutom uppmärksammas hur de anställda samordnarna uppfattades och kategoriserades. I institutionspersonalens framställning är samordnarens The aim of this study is to map out and describe the way employees in Swedish juvenile homes interpret, define and perceive, on the one hand, the project “Motverka Våld och Gäng” meaning “Counteract Violence and Gangs”, and on the other hand the role of the Coordinators employed in this project. The role of the Coordinator is formally clear and unproblematic. The project management directives sta
Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell d
