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INTRODUCTION: We studied whether adding percent free prostate-specific antigen (%fPSA) to total PSA improves prediction of clinically significant prostate cancer (csPCa) and fatal PCa.METHODS: 6727 men within the intervention arm of the Prostate, Lung, Colorectal and Ovarian Trial had baseline %fPSA. Of this cohort, 475 had csPCa and 98 had fatal PCa. Cumulative incidence and Cox analyses were con
In recent years, more than 2000 jurisdictions worldwide have declared a climate emergency. While such declarations have been suggested to have the potential to spark transformative climate action, there is much disagreement about the merits of climate emergency framings. Moreover, no studies have been conducted on the topic from a Swedish perspective. This study addresses this research gap by expl
Synovial fluid (SF) may contain cleavage products of proteolytic activities. Our aim was to characterize the degradome through analysis of proteolytic activity and differential abundance of these components in a peptidomic analysis of SF in knee osteoarthritis (OA) patients versus controls (n = 23). SF samples from end-stage knee osteoarthritis patients undergoing total knee replacement surgery an
BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively
This article explores some of the key institutional challenges hindering the development of a new ‘social’ housing cooperative model in Finland. In response to rising housing unaffordability and insecurity in the private housing sector, and a retrenching social housing sector, Finland is experiencing a resurgence of practical and political interest in housing cooperatives. Based on a document stud
Background: The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional.Method: An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diag
As the coronavirus started to spread in Ireland, the epidemiological data became the most sought-after information in the country. This article will examine the ways in which COVID-19 redefined the intimacies of the relationships that health professionals and the members of the public have with medical data. It will focus on Irish examples and explore how the context of the pandemic turned numbers
Background: There is a great unmet clinical need to identify patients with thin primary cutaneous melanomas (T1, Breslow thickness ≤ 1 mm) who have a high risk for tumor recurrence and death from melanoma. Kin of IRRE-like protein 1 (KIRREL/NEPH1) is expressed in podocytes and involved in glomerular filtration, but its expression in human cancer has not yet been reported. Screening in the Human Pr
Background: After neoadjuvant chemotherapy (NAC), about 20% of pts with muscle-invasive UC are found to have advanced pT-stage or lymph node involvement and 5-year overall survival (OS) of them is < 30%. Tumor samples from these pts may provide information about chemotherapy resistance, and may predict for the activity of new drugs given postoperatively. Alterations of FGFR3 gene represent a thera
This article shows the importance in human rights law of the right to leave any country, particularly in the light of increasing efforts by European countries of destination to prevent departures, and to contain movement by enrolling countries of origin and transit to act as gatekeepers. The article highlights the autonomous nature of the right and clarifies the challenges in triggering its applic
Objectives: This study aimed to investigate the occurrence of suicidal ideation and associated factors in older persons with dementia living at home in eight European countries, and its association with quality of life. Furthermore, changes in suicidal ideation over time were investigated. Methods: This cohort study (n = 1,223) was part of the European “RightTimePlaceCare” project conducted in 201
Poverty and social exclusion remain some of the biggest concerns in the face of obtaining social sustainability. In this respect, the continuing immense spatial differences between individual localities of seemingly similar characteristics have puzzled social scientists for decades. In quest for a better understanding, this article highlights the role of spatial heterogeneity as a factor conducive
OBJECTIVES: Atherothrombosis in the carotid arteries is a main cause of ischemic stroke and may depend on plaque propensity to complicate with rupture or erosion, in turn related to vulnerability features amenable to in vivo imaging. This would provide an opportunity for risk stratification and-potentially-local treatment of more vulnerable plaques. We here review current information on this topic
INTRODUCTION: Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. METHODS: A nationwide cohort study was conducted using Swedish family cancer data sets, inpatient, and o
The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c
Test "Title" Effects of the Introduction of Pied Flycatchers Ficedula hypoleuca on the Composition of a Passerine Bird Community ANDERS ENEMAR & BENGT SJOSTRAND Enemar, A. & Sjostrand, B. Effects of the Introduction of Pied Flycatchers Ficedula hypoleuca on the Composition of a Passerine Bird Community. Ornis Scand. 3, 79-89, 1972. A nest-box experiment was carried out in rich subalpine birch fore
https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-024enemar_mflholkexperim.pdf - 2026-06-27
LIFEGENE EpiHealth Ethics Policy, Version 1, 2010-11-09 Page 1 of 18 EpiHealth Ethics Policy Version 1, November 9, 2010 2 Table of Contents Table of Contents ............................................................................................... 2 EpiHealth - Purpose and overview ..................................................................... 4 I. Relationship with participants ....
https://www.epihealth.lu.se/sites/epihealth.lu.se/files/epihealth_ethics_policy_101108_0.pdf - 2026-06-27
