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Background: Health effects and health care seeking were investigated among women in rural Vietnam exposed to physical and/or sexual violence from their partner in the past year. The study was conducted within the framework of the demographic surveillance site in Bavi District, Ha Tay Province in northern Vietnam. Methods: Face-to-face interviews based on a questionnaire developed by the WHO for us
BACKGROUND. Prostate-specific antigen (PSA/KLK3) and human kallikrein 2 (hK2/KLK2) belong to the human kallikrein gene family. These two highly homologous genes are specifically expressed in the prostate under androgen control. Expression of these is regulated by similar mechanisms but changes in their relative expression have been observed in prostate cancer. METHODS. We determined the relative l
The recently cloned human chemoattractant receptor-like (CMKRL)1, which is expressed in vivo in CD4-positive immune cells, has structural homology with the two chemokine receptors C-C chemokine receptor (CCR)5 and C-X-C chemokine receptor (CXCR)4, which serve as the major coreceptors necessary for fusion of the HIV-1 envelope with target cells. In view of the structural similarity, CMKRL1 was test
Popular Abstract in Swedish Är ledgångsreumatism en immunreaktion mot brosk? Kroppens immunförsvar bygger på ett antal olika vita blodkroppar, immunceller, som cirkulerar i blod och lymfa på spaning efter främmande och farliga "angrepp". Immuncellerna sägs svara på "angrepp", sådana immunsvar dirigeras av s k T-hjälparceller (Th-celler). Th-cellerna kommer från benmärgen, men de blir inte funktioThis thesis is based on work trying to understand the normal and pathological interactions taking place between the immune system and cartilage, specifically involving the cartilage-specific protein typ II collagen (CII). The work has been carried out in an experimental model of rheumatoid arthritis namely collagen type II induced arthritis (CIA) in mice. CIA can be triggered in mice of certain MH
Recently, semiotics has begun to be related to computing. Since semiotics is about the interpretation of signs, of which language is a chief part, such an interest may seem quite reasonable. The semiotic approach is supposed to bring semantics to the computer. In this paper I discuss the realistic in this from the point of view of computers as linguistic systems, that is, as interpreters of descri
Numerical analysis, such as the finite element method is the most used computational procedure for nonlinear deformation and strength analysis of structures. In order to obtain meaningful results the material behaviour must be described and simulated accurately. Another important element in order to perform the simulation is a robust and accurate numerical integration algorithm. The present paper
The objective of this paper is to provide a classification of recycling policy measures in relation to the actual recycling levels achieved in the EU Member States and in the European Environment Agency member countries. The paper covers the following five waste streams: packaging waste, waste electrical and electronic equipment (WEEE), municipal solid waste (MSW), biodegradable municipal waste (B
Antibody microarray technology has the potential for playing a large roll in identifying serological biomarker panels for personalized medicine. The aim of this thesis, based on four original papers, was to investigate if information in the serum proteome could be extracted and used for diagnostic, classificational, prognostic or treatment predictive purposes in a range of diseases. In two studies
Leptospirosis is a worldwide spread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. In severe infections, hemostatic impairments such as coagulation/fibrinolysis dysfunction are frequently observed. These complications often occur when the host response is controlled and/or modulated by the bacterial pathogen. In the presen
Background: Previous work has demonstrated immunomodulatory, anti-tumor, anti-metastatic and anti-angiogenic effects of the small molecule quinoline-3-carboxamide tasquinimod in pre-clinical cancer models. To better understand the anti-tumor effects of tasquinimod in transplantable tumor models, we have evaluated the impact of the compound both on recruitment of myeloid cells to tumor tissue and o
This paper describes the involvement of end users in a project aimed to create a navigation aid for older persons who have memory decline, which affects navigation skills, and thus their independence. Interviews, focus groups with “stick man scenarios” and shorter usability tests seemed to work well. An extended test where the users themselves were expected to use the system independently was not
In almost all countries in the Middle East and North Africa (MENA) region, power sectors are characterized by a high degree of vertical integration and state control. However, several countries have undertaken reforms in order to open up the power market for private sector involvement particularly in relation to renewable energy (RE) sourced electricity generation. The majority of the MENA countri
Background: We here study antibodies against phosphorylcholine (anti-PC) which we reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and autoimmune conditions. In previous studies, we determined that this inverse association is more pronounced at low levels with high risk and at high levels, with decreased risk. We compare individuals from Kitava, New Guinea (w
Extended Producer Responsibility (EPR) schemes are adopted not only to promote collection and recycling of waste products but also to close material loops and incentivise ecodesign. These outcomes are also part of creating a more circular economy. Evaluations of best practices can inform how to further optimise systems towards more ambitious collection, recycling and recovery of both hazardous and
Popular Abstract in Swedish Antikroppar är proteiner som ingår i kroppens immunförsvar, där de fungerar som bindare för att neutralisera patogena mikroorganismer eller ämnen som infekterat kroppen. Vid en infektion börjar immunceller producera antikroppar genom att på ett smart sätt sätta ihop olika gener. Varje enskild immuncell använder en viss kombination av gener och producerar därmed antikropRecombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. Pancreatic cancer is the 4th deadliest cancer, with a 5-year survival rat
An amino-terminal region of a, chain of type IV collagen noncollagenous domain [alpha(3)(IV)NC1] that induces experimental autoimmune glomerulortephritis (EAG) in rats has been identified. Only recombinant antigens that contain a nine-amino acid (AA) span of alpha(3)(IV)NC1, consistent with a T cell epitope, could induce EAG. It was hypothesized that synthetic peptides of this region should induce
