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Disease and death caused by bacterial infections are global health problems. Effective bacterial strategies are required to promote survival and proliferation within a human host, and it is important to explore how this adaption occurs. However, the detection and quantification of bacterial virulence factors in complex biological samples are technically demanding challenges. These can be addressed
Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro
Popular Abstract in Swedish Vi lever i en tid då klimatförändringar är en fråga som engagerar, men det krävs en djupare förståelse för hur och varför vårt klimat har förändrats för att möjliggöra realistiska förutsägelser om framtiden. Efterhand som olika metoder för att rekonstruera klimatförändringar har förfinats, och nya dateringsmetoder har utvecklats, så har förståelsen för hur klimatet föräDendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in South Swedish peat deposits. By cross-dating Swedish bog-pine ring-width (RW) chronologies with corresponding material from North-west Germany, three Swedish RW chronologies were assigned absolute ages and yielded continuous, dated chronologies over the periods 5284-3728 BC and 2668-1108 BC.
Background The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and is thereby a potent inhibitor of neutrophil chemotaxis and activation of inflammatory responses. The majority of the healthy human population has antibodies against CHIPS that have been shown to interfere with its function in vit
Genetic segregation analysis between NOD and C57BL strains have been used to identify loci associated with autoimmune disease. Only two loci (Cia2 and Cia9) had earlier been found to control development of arthritis, whereas none of the previously identified diabetes loci was of significance for arthritis. We have now made a high-powered analysis of a backcross of NOD genes on to the B10.Q strain
Objectives: To describe a nationwide system for postmarketing follow up of new antirheumatic drugs in Sweden, and to analyse safety and effectiveness in an etanercept treated patient cohort. Methods: Etanercept became available in Sweden for prescribing on a named patient basis in 1999. All patients treated were included in a follow up of intensified adverse event reporting and recording of clinic
Popular Abstract in English Climate migration has become an iconic topic in international climate politics and policy. This work, combining political ecology, critical security studies and post-foundational theories, traces the changes of conflicting discourses across time and space, and assesses the different forms of security they interpellate. While initially attracting attention as a securityThis work seeks to de-naturalise climate-induced migration (CM). Combining political ecology and post-foundational theories, I read CM as a construct that reifies a series of phenomena into an issue to be researched and governed. By assessing the narratives, the knowledge, the logics and imaginaries on which conflicting discourses are built, I analyse the strategies of government they envision. I
Abstract in Uncoded languages Tarptautiniai klimato kaitos susitarimai ir Europos Sąjungos teisės aktai veikia skirtingus valdymo lygmenis, įskaitant nacionalines teisės sistemas ir administravimo modelius. Disertacijoje iškeltas tyrimo klausimas – Kaip Lietuva, konkrečiai pramonės sektorius, įgyvendina šiltnamio efektą sukeliančių dujų (toliau – ŠESD) emisijų mažinimo reikalavimus, nustatytus KioInternational climate change agreements and the European Union legislation have an influence on different levels of governance, including national legal systems and administrative schemes. The following research question is addressed in the doctoral dissertation: “How does Lithuania, specifically the industrial sector, implement GHG reduction requirements under the Kyoto Protocol and the European
The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. This thesis, which is based on four original papers, deal with antibody d
This paper presents the development as well as the architecture of a computer-aided dedicated fixture design system intended to support the design of lightweight (carbon fiber composite) grippers for a major truck company. Lightweight grippers were required due to the increasing production rates in the automotive industry. The current robotic equipment was facing diverse problems during transporta
Objectives To describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV). Methods Data were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Da
There has been much debate on the topic of whether stricter environmental regulations can promote environmental performance and economic performance at the same time. Different researchers have used different indicators to measure environmental performance and economic performance in their empirical studies. However, it is a surprise that few studies have checked the relationship between environme
BACKGROUND: Beans are rich and inexpensive sources of proteins and carbohydrates around the world, but particularly in developing countries. However, many legume varieties are still underutilized. In this study, physical characteristics of the seeds of three Phaseolus lunatus cultivars were characterized. Also, the chemical composition and starch digestibility in the cooked beans were assessed. RE
Image segmentation among overlapping land cover areas in satellite images is a very crucial task. Detection of belongingness is the important problem for classifying mixed pixels. This paper proposes an approach for pixel classification using a hybrid approach of Fuzzy C-Means and Cellular automata methods. This new unsupervised method is able to detect clusters using 2-Dimensional Cellular Automa
A comparative experimental investigation has been performed, comparing the emissions from a synthetic jet fuel and from Jet AI. In the investigation, the unburned hydrocarbons were analyzed chemically and the regulated emissions of NOX, CO and HC were measured. All combustion tests were performed under elevated pressures in a gas turbine combustor rig. A Swedish company, Oroboros AB, has developed
Deterministic lateral displacement (DLD) is a powerful bimodal separation scheme [1] based on fluid flow through regular obstacle arrays that in its basic embodiment sends suspended particles in two different directions as a function of size. We show that without the need to seal devices and without the need for fluidic connections or pumps, particle separation can be achieved by the passive flow
The fifth generation wireless system (5G) is expected to handle an unpredictable number of heterogeneous connected devices and to guarantee at least the same level of security provided by the contemporary wireless standards, including the Authentication and Key Agreement (AKA) protocol. The current AKA protocol has not been designed to efficiently support a very large number of devices. Hence, a n
This study delineates the permissible scope for compulsory mental health interventions under the Convention on the Rights of Persons with Disabilities (CRPD). It was initially triggered by two competing positions within the current debate over the future of coercive psychiatry; a practice that is still omnipresent among states worldwide. According to one position, defended by the CRPD Committee amThis study delineates the permissible scope for compulsory mental health interventions under the Convention on the Rights of Persons with Disabilities (CRPD). It was initially triggered by two competing positions within the current debate over the future of coercive psychiatry; a practice that is still omnipresent among states worldwide. According to one position, defended by the CRPD Committee am
In Sweden, various public health interventions have been performed to reduce risky sexual behaviors among young people and promote safer and positive approaches to sexuality, while attempting to bridge the gap between the less privileged or more vulnerable young people and their more privileged peers. This study aimed to compare the individual- and familial-level determinants of risky sexual behav
Presently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analyPresently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analy
