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Mary Flannery O’Connor (1925-64) was born in Savannah, Georgia as the only child of the American Irish Catholics Edward Francis O’Connor, Jr. and Regina Cline O’Connor. In 1952 her first novel Wise Blood, in 1955 the short story collection A Good Man Is Hard to Find, and in 1960 her second novel, The Violent Bear It Away were published. She received several fellowships and titles of Honorary Docto
Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.
Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and "immune staging". The quantity and quality of starting peripheral blood mononuclear cell (PBMC) preparations are important factors in the performance of such assays. We therefore compared final PBMC yield and function by modifying parameters at the b
Pools of frozen biopsies from patients with squamous cell carcinoma (SCC) (n=29) actinic keratosis (AK) (n=31), keratoacanthoma (n=91) and swab samples from 84 SCCs and 91 AKs were analysed with an extended HPV general primer PCR and high-throughput sequencing of amplimers. We found 273 different HPV isolates (87 known HPV types, 139 previously known HPV sequences (putative types) and 47 sequences
BACKGROUND: The objective of lung transplantation (LTx) is to prolong life, but the survival benefit for patients with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema is still unclear. The aim of this study was to assess whether PiZZ patients who have undergone lung transplantation (the lung transplant group, TxG) do better than patients who have continued on the usual medical therapy (th
Popular Abstract in Swedish Under 1990-talet har många kommunala verksamheter ställts inför ökade kostnader av äldre- och handikappomsorgen och flera organisatoriska förändringar har genomförts. Nya problem och dess lösningar beskrivs ofta förlagda till chef- och ledarskapsområdet. Chefer och ledare inom offentlig verksamhet har under de senaste åren tillskrivits en nästan magisk betydelse för verDuring the 1990s many of the local authorities have been forced to reduce expenditure on the care of the elderly and people with disabilities, and many organisational changes have been carried out. New problems and their solutions are often related to leadership and management. This dissertation deals with three trends in the development of the organisation: The first trend is a market orientation
Objective: Individual-based studies on restricted geographical settings have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may precipitate congestive heart failure. As NSAID use is very extensive, it might increase the occurrence of symptomatic heart failure in the general population. Therefore, in order to study the impact of NSAID utilisation (prescribed and over the counter) on h
Three evacuation experiments were performed to investigate how emergency exits should be designed. In the first two experiments coloured flashing lights and strobe lights at emergency exits were tested and compared to a standard emergency exit design. In the third experiment green, blue, orange and red lights were compared to determine which colour was the most appropriate for use in emergencies.
Recent observations by the Goddard High-Resolution Spectrograph on the Rubble Space Telescope have dramatically improved our knowledge of the abundance of the heaviest elements in Mercury-Manganese (HgMn) stars (c.f. Leckrone et al. 1992 and Wahlgren et al. 1995). Explaining the observed abundance and isotope anomalies requires improved calculations of radiatively driven diffusion. We briefly revi
BACKGROUND: Prostate-specific antigen (PSA) occurs in different molecular forms in serum: free PSA (fPSA) and complexed PSA (cPSA), the sum of which corresponds to total PSA (tPSA). In addition to tPSA, percent fPSA is widely used in the detection of prostate cancer. Free PSA, approximately 28 kDa, is eliminated by glomerular filtration. Previous data showed that men with end-stage renal dysfuncti
Detectable debris discs are thought to require dynamical excitation (`stirring'), so that planetesimal collisions release large quantities of dust. We investigate the effects of the secular perturbations of a planet, which may lie at a significant distance from the planetesimal disc, to see if these perturbations can stir the disc, and if so over what time-scale. The secular perturbations cause or
The development of a common data base system for wastewater treatment operating data evaluation is discussed. Data records from wastewater treatment plants which have been converted into standard files in a common data base are used as a case study. Advanced programs for data analysis and simulation have been used to evaluate the data in the common data base. The paper discusses software standardi
Open surgical total aortic arch replacement is a demanding procedure which carries a substantial morbidity and mortality. A less invasive endovascular option is endovascular stent grafting using in situ fenestrations. After thoracic stent graft deployment in the arch, fenestrations are made for the major arch vessels. During this procedure, antegrad cerebral perfusion is maintained using a tempora
Popular Abstract in Swedish Från 1980-talet har etiken diskuterats flitigt i samhället. Det har i samband med detta utvecklats etiska kommittéer. Etiska kommittéer är en typ av organ inom företag, branscher, professioner och andra organisationer som handhar etiska frågor och problem. De etiska kommittéerna fungerar rådgivande i etiska frågor, de kan fastställa etiska regler för en organisation ochThis thesis analyses the development of ethics committees from a sociology of law perspective and a social steerage perspective ("social control"). The main question is: Why are ethics committees established? Institutionalised ethics committee is a rather new phenomenon, which has become widely spread in the last 20 years. The study points out the public ethical debate since the 1980s as a major e
Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of properdin by monocytes was examined in type I deficiency and in two unrelated cases with type II deficiency, one from a Swedish and one from a Da
The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c
Background: Concerns about the cardiovascular safety of medications used for the treatment of attention-deficit hyperactivity disorder (ADHD) remain. We aimed to compare the effects of pharmacological treatments for ADHD on haemodynamic values and electrocardiogram (ECG) parameters in children, adolescents, and adults. Methods: For this systematic review and network meta-analysis, we searched 12 e
