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Thesis purpose: To identify and describe the corporate brand identity of a successful company from the mobile gaming industry, examining its corporate brand development at different growth stages. Methodology: This thesis assumes a constructionist ontological stance and interpretivist epistemological position. We chose an exploratory, qualitative single case study approach where semi-structured i
Healthy regeneration of tissue relies on a well-orchestrated release of growth factors. Herein, we show the use of synthetic glycosaminoglycans for controlled binding and release of growth factors to induce a desired cellular response. First, we screened glycosaminoglycans with growth factors of interest to determine kon (association rate constant), koff (dissociation rate constant), and Kd (equil
Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that shows overlapping features with PRDM10-rearranged soft tissue tumor (PRDM10-STT). This study characterizes the clinicopathologic, immunohistochemical, and molecular features of SCD34FT in a series of 59 cases. Fluorescence in situ hybridization to assess for PRDM10 rearrangement was performed in 12 tumors. I
Introduction: biomaterials combined with antibiotics are routinely used for the management of bone infections. After eluting high concentrations of antibiotics during the first week, sub-inhibitory concentrations of antibiotics may lead to late repopulation of recalcitrant bacteria. Recent studies have shown that systemically given antibiotics like tetracycline and rifampicin (RIF) could seek and
Budget 2018 Budget 2019 Budget 2020 General Budget MultiPark EMV OH 21%? EMV OH 21%? EMV OH 21%? Income 27 891 000 27 891 000 27 891 000 Balance from previous year (estimated) 1 487 535 4 762 007 7 366 029 Rent subvention 191 389 191 389 191 389 Income Total 29 569 924 32 844 396 35 448 418 Management Coordinators (2 persons 50%) 952 030 971 071 990 492 Admin personnel (2 persons, 165%) 1 225 987
https://www.multipark.lu.se/sites/multipark.lu.se/files/2017-12-11.pdf - 2026-07-17
The aim of the thesis is to describe and analyze the Swedish public psychiatric hospitals between 1850 and 1970 as well as the treatment, care and custody that these hospitals provided. The study has as its starting point two relationships. The first is the relationship between the patient’s body and the space of the institution. One focus is on how the patient’s body has been enclosed by the inst
The development of advanced computational fluid dynamic codes for turbine design does not substitute the importance of mean-line codes. Turbine design involves mean-line design, through-flow design, airfoil design, and finally 3D viscous modeling. The preliminary mean-line design continues to play an important role in early design stages. The aim of this paper was to present the methodology of mea
AIMS/HYPOTHESIS: Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the voltage-dependent Ca(2+) channel Ca(V)2.3 (CACNA1E), telomeric to a region that has shown suggestive linkage to type 2 diabetes (1q21-q25), has been ascribed a role for seco
Inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells. Cytogenetic analyses have revealed that a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements involving chromosome band 2p23. Further, molecular genetic studies have shown that these rearrangements target the ALK
Technologies to develop and evolve the function of proteins and, in particular, antibodies have developed rapidly since the introduction of phage display. Importantly, it has become possible to identify molecules with binding properties that cannot be found by other means. A range of different approaches to create general libraries that are useful for the selection of such molecules specific for e
Neurodegenerative diseases have been linked to inflammation, but whether altered immunomodulation plays a causative role in neurodegeneration is not clear. We show that lack of cytokine interferon-β (IFN-β) signaling causes spontaneous neurodegeneration in the absence of neurodegenerative disease-causing mutant proteins. Mice lacking Ifnb function exhibited motor and cognitive learning impairments
Transforming growth factor beta 1 (TGFB1) acts as a growth inhibitor of normal colonic epithelial cells, however, as a tumor promoter of colorectal cancer (CRC) cells. To explore the association between genetic polymorphisms in the TGFB1 pathway and CRC susceptibility and clinical outcome, we carried out a case-control study on a Swedish population of 308 CRC cases and 585 age- and gender-matched
Abstract Digital visualization has gone through a revolutionary decade. Compared to other fields where these methods have been applied, archaeology has been, and still is, more resistant to integrating tools and instruments able to describe materials and scenarios with high resolution. This is partly due to the archaeological misconception of high cost of scientific equipment and the complexity in
Antibody-based microarray is a novel technology with great potential within high-throughput proteomics. The process of designing high-performing antibody (protein) microarrays has, however, turned out to be a challenging process. In this study, we have developed further our human recombinant single-chain variable-fragment (scFv) antibody microarray methodology by addressing two crucial technologic
Context: Dipeptidyl peptidase-4 (DPP-4) inhibitors act by increasing plasma levels of glucagon-like peptide-1 (GLP-1) and suppressing excessive glucagon secretion in patients with type 2 diabetes (T2DM). However, their effects on the glucagon response to hypoglycemia are not established. Objective: Assess effects of the DPP-4 inhibitor vildagliptin on alpha-cell response to hyper- and hypoglycemia
1 Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study Short Running Title: GI infections modulate autoantibody-risk Maria Lönnrot MD PhD1, Kristian F. Lynch PhD2, Marian Rewers MD PhD3, Åke Lernmark PhD4 Kendra Vehik PhD2, Beena Akolkar PhD5, William Hagopian MD PhD6, Jeffrey Krischer PhD2, Rickhard A. McIndoe PhD7, Jorma
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-12/155_MP22b_Lonnrot_Diab%20Care_2023_Accepted%20version.pdf - 2026-07-17
Introduction: Post-traumatic stress disorder (PTSD) and substance use disorder frequently co-occur and tend to have their onset during adolescence. Although research has highlighted the importance of treating these disorders in an integrated fashion, there is a dearth of empirically validated integrated treatment options for adolescents with this comorbidity. This paper describes the study protoco
Introduction: Acute kidney injury (AKI) after cardiac surgery is common and results in increased morbidity and mortality. One possible mechanism for AKI is ischaemia-reperfusion injury caused by the extracorporeal circulation (ECC), resulting in an opening of the mitochondrial permeability transition pore (mPTP) in the kidneys, which can lead to cell injury or cell death. Ciclosporin may block the
