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We report the use of multinodal acoustic trapping for high throughput and high capacity capturing of EV's (extracellular vesicles) for quantitative mass spectrometry analysis. The multinode trapping unit was shown to isolate sufficient amount of EV's from dilute biological samples (urine and cell culture supernatant) at flow rates of 500 ul/min within minutes, enabling EV proteome profiling. This
The inherent properties of cells and micro-organisms is an under-explored source of specificity for particle sorting. In contrast to standard immunolabeling it allows us to perform fractionation without any chemical preparation of the sample. This improves the accessibility and affordability of the technology. Our contribution in the field is to extend the scope of deterministic lateral displaceme
DLE (Dry Low Emission) techniques are widely used today to reduce the harmful NOx emissions associated with high combustion temperatures. In many DLE systems the fuel and air are premixed which effectively keep the flame temperature as low as possible, ideally equal to the turbine inlet temperature. By using premixing stability issues such as flash back and combustion driven dynamics may occur. Op
Solution and solution-deposited thin films of the discotic liquid crystalline electron acceptor–donor–acceptor (A-D-A) p-type organic semiconductor FHBC(TDPP)2, synthesized by coupling thienyl substituted diketopyrrolopyrrole (TDPP) onto a fluorenyl substituted hexa-peri-hexabenzocoronene (FHBC) core, are examined by ultrafast and nanosecond transient absorption spectroscopy, and time-resolved pho
One way to facilitate electrochemical communication between bacterial cells and electrodes is the use of artificial redox mediators. There are, however, a number of drawbacks when they are used in their freely diffusing monomeric form. In contrast when bound to flexible polymeric backbones they not only serve as mediators but also as an immobilization matrix forming a 3D hydrogel on the electrode
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https://www.maths.lu.se/utbildning/alla-kurser/kursutvaerderingar/numerisk-analys-nf/ - 2026-07-18
Three incommensurately modulated gamma-brass-related composite structures in the Ni-Zn system have been solved from Xray single crystal diffraction data using a 3+1 dimensional super space description. The compounds at the end points of the compositional domain NiZn3-delta (-0.09 <= delta <= 0.34) and NiZn3.30 crystallize in the orthorhombic superspace group Fmmm(alpha 00) 0s0 {F = [(1/2, 1/2, 0,
Despite recent technological advancements allowing the characterization of cancers at a molecular level along with biomarkers for cancer diagnosis, the management of ovarian cancers (OC) remains challenging. Proteins assume functions encoded by the genome and the complete set of proteins, termed the proteome, reflects the health state. Comprehending the circulatory proteomic profiles for OC subtyp
This project has investigated tools that could be used for somatic (non-inherited) variant calling using RNA-sequence (RNA-seq) data from patients with non-small cell lung cancer (NSCLC). Identifying specific genetic variation causing growth of cancerous cells have been a major challenge within cancer research and diagnostics. Variant calling uses sequenced data to analyze differences in the genom
Despite oncogene amplification being a characteristic of many tumor types, the mechanisms leading to amplicon formation have remained largely unresolved. In this study, we used a combinatorial approach of fluorescence in situ hybridization and single-nucleotide polymorphism chip gene copy number analyses to unravel the mechanism leading to nonsyntenic coamplification of MYC and ATBF1 in SJNB-12 ce
Popular Abstract in Swedish MHC upptäcktes för 60 år sedan då George Snell konstaterade att möss som var genetiskt lika inte stötte bort transplanterad hud medan genetiskt olika möss gjorde det. Men det var inte förrän långt senare som man insåg vilken roll som MHC spelar i immunförsvaret hos alla vertebrater. Sedan ett par decennier tillbaka är detta ett välstuderat område speciellt hos människanIn birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. In this thesis I have partly characterized MHC class I in house sparrows (Passer domesticus), sequencin
Chemical solution deposition (CSD) offers the opportunity to fabricate very thin electrolyte films at lower temperatures than traditional powder-based methods. CSD methods have not been used much in production of protonic ceramic fuel cells (PCFC) until now. In this contribution we describe thin film deposition of the two proton-conducting materials BaZr0.9Y0.1O3 (-) (delta) (BZY) and La28 - xW4 +
Rare-variant association studies in common, complex diseases are customarily conducted under an additive risk model in both single-variant and burden testing. Here, we describe a method to improve detection of rare recessive variants in complex diseases termed RAFT (recessive-allele-frequency-based test). We found that RAFT outperforms existing approaches when the variant influences disease risk i
In this paper, we present a fluorescence activated sorter realized in a continuous flow microfluidic chip. Sorting is achieved by deflecting a focused particle stream with short acoustic bursts (2.5 ms), in a fluorescence activated configuration. The system utilizes two-dimensional acoustic pre-focusing, using a single actuation frequency, to position all particles in the same fluid velocity regim
Popular Abstract in Swedish Elektriska pulser (PEF) är en nyligen introducerad icke-termisk livsmedelsprocess, som har en karakteristisk påverkan på cellmembranet. PEF-behandling innebär att livsmedlet utsätts för korta och upprepade pulser emellan en anod och en katod. Det huvudsakliga resultatet av denna process är en skada på cellmembranet, som leder till bildandet av antingen tillfälliga ellerA pulsed electric field (PEF) is a newly emerged non-thermal food processing technology which has characteristic effects on the cell membrane. PEF processing involves subjecting food to short, repeated pulses of a high electric field between an anode and a cathode. The main result of this process is the disruption of the cell membrane leading to the formation of either temporary or permanent pores
A considerable part of latency in the baseband of massive multiple-input multiple-output (MIMO) systems is introduced by orthogonal frequency division multiplexing (OFDM) (de)modulation. To address the low-latency demand of massive MIMO systems, a fast Fourier transform (FFT) processor and corresponding reordering scheme are proposed, which reduce the processing latency and reordering latency of O
We present a novel approach to the 3D sound source localization task for distributed ad-hoc microphone arrays by formulating it as a set-to-set regression problem. By training a multi-modal masked autoencoder model that operates on audio recordings and microphone coordinates, we show that such a formulation allows for accurate localization of the sound source, by reconstructing coordinates masked
