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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192697 hits
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Retailing Retold offers an alternative approach to the analysis of how international retail images are translated across national boundaries. The approach extends the view on image in previous research as an instrument for monitoring the effects of marketing strategies on consumers’ perceptions of the retailer. Instead, it suggests that the usefulness of image resides in its ability to capture the
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This thesis examines mechanisms regulating bacterial nitrification and denitrification in attached microbial communities on surfaces of aquatic macrophytes. It also evaluates the role of epiphytic nitrification and denitrification for the nitrogen turnover in macrophyte-dominated nutrient-rich freshwaters. Epiphytic nitrification is promoted in light and epiphytic denitrification occurs mainly in
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Popular Abstract in Swedish Små partiklar i form av vätska eller fast material mellan 0.001 till 100 µm i diameter, kan sväva i luften och kallas då aerosolpartiklar. De påverkar direkt på klimatet genom att reflektera solstrålar ut till rymden. Detta gör att vi får ett kallare klimat. Indirekt kan de påverka klimatet genom att verka som kondensationskärnor vid molnbildning. Med detta påverkar de The aim of this work was to study atmospheric aerosols, focusing on the chemical composition, the morphology and the origin of the aerosol in the upper troposphere and lowermost stratosphere. An aerosol sampler was developed for this purpose. A new method for quantitative analysis of the major components of the aerosol, i.e. C, N and O was developed, and methodologies for single-particle analysis
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The importance of prioritising requirements is widely recognised. A number of different techniques for prioritising requirements have been proposed, some based on an ordinal scale, others on a ratio scale. Some measurement scales provide more information than others, i.e. the ratio scale is richer than the ordinal scale. This paper aims to investigate the differences between the scales used in pri
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Popular Abstract in Swedish Jet impingement och infraröd strålning är metoder för snabb värmeöverföring som kan användas för att snabba upp värmeprocesser i livsmedelsindustrin. Värmningshastigheten påverkar viktiga egenskaper hos livsmedlet, t.ex. brunfärgning. Jet impingement består av riktade strålar av luft med hög hastighet som träffar ytan på livsmedlet och minskar gränsskiktet mellan luftenRapid heat transfer methods such as jet impingement and infrared radiation can be used to speed up thermal processing in the food industry. The heating rate affects important food characteristics, such as colour. Jet impingement consists of directed jets of air with a high velocity that impinge on the food surface, which reduces the velocity boundary layer between the air and surface and gives a f
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How to judge religions other than one’s own when facing a plurality of religions? The author makes a philosophical inquiry in two interconnected fields, linguistic undecidability and the necessity of making judgements. The central claim is that no stable centre for meaning can be established for linguistic entities. Even in cases where a stable centre of meaning would seem to be required, the auth
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Popular Abstract in Swedish När en kärlskada uppstår måste skadan repareras innan alltför mycket blod hinner lämna blodbanan. Kärlet självt kan dra ihop sig till viss del för att minska blodflödet. Vid kärlskadan exponeras strukturer som normalt inte skall ha kontakt med blodet, en sådan struktur är t.ex. ämnet kollagen. Till kollagenet binds blodplättar (trombocyter) som tillfälligt täpper till sThe investigations presented in this thesis have evaluated different strategies to prevent thrombosis in an experimental model of deep arterial injury in rats. Unfractionated heparin (UFH) is often used to prevent thrombosis in microvascular surgery and in other vascular interventions, but a major drawback of UFH is increased bleeding. In the first paper the low-molecular-weight heparin (LMWH) da
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Popular Abstract in Swedish Diabetes är en världssjukdom – om 50 år räknar det internationella diabetesförbundet med att en tiondel av världens befolkning har någon form av diabetes. Diabetes innebär att kroppen inte kan ta hand om allt socker som man äter. Detta medför att sockerhalten i blodet blir för högt. Högt blodsocker gör att kroppens celler arbetar konstant, och om blodsockret är för högtThe primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. This has been investigated in three different studies, which concluded the following: Study 1) GPR30 is expressed in female mice pancreatic isle
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Background. It is expected that fuel cells will play a significant role in a future sustainable energy system, due to their high energy efficiency and possibility to use renewable fuels. Fuels, such as biogas, can be produced locally close to the customers. The improvement for fuel cells during the last years has been fast, but the technology is still in the early phases of development, however th
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Popular Abstract in Swedish En av de viktigaste frågeställningarna inom molekylär genetik är hur uttrycket av människans ca 30-40 000 gener regleras i tid och rum. En typ av reglering som är väldigt viktig är transkriptionell reglering och denna utövas av proteiner som kallas transkriptionsfaktorer. Dessa binder till specifika områden i DNA strängarna i närheten av genkodande regioner och kan däriNeuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. It is well established that transcription factors control the steps leading to neuronal differentiation, and a number of basic helix-loo
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Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with the incorporation of AI in endoscopy are being addressed in recent consensus documents. Objectives: In the current paper, we aimed to map future challenges and areas of research fo
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Objectives: We aimed to explore the association between various physiological factors and pyelonephritis in parous women. Methods: Swedish nationwide registers were used to identify 1,073,467 parous women aged 15-50 years. The study period began in 1997 and ended in 2018, or at the first incidence of pyelonephritis, death, or emigration. Cox proportional hazards methods were used to determine haza
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Aim: The influence of dietary carbohydrates and fats on weight gain is inconclusively understood. We studied the acute impact of these nutrients on the overall metabolic state utilizing the insulin:glucagon ratio (IGR). Methods: Following in vitro glucose and palmitate treatment, insulin and glucagon secretion from islets isolated from C57Bl/6J mice was measured. Our human in vivo study included 2
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Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), le
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TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid Δ9-tetrahydrocannabiorcol (C16) and by probenecid. C16 and probenecid act in concert to stimulate TRPV2 responses including histamine release from
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Heterostructured nanowires exhibit unique physical and electronic properties and are most commonly grown by the vapor-liquid-solid mechanism. Some of these properties are related to the interfacial abruptness of the heterointerface which makes its understanding and control particularly important for further development. In this regard, we present a model based on mass balance of atoms in the catal
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Climate change is expected to alter precipitation regimes, resulting in longer periods of drought and heavier precipitation events. Even though the direct effect of water availability on soil microbial processes is well documented, the influence of precipitation legacy on microbial resistance and resilience to drought remains unclear. Using soils from a natural mean annual precipitation (MAP) grad
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Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period o
