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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193006 hits

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We present a statistical mechanics theory of rubber-like elasticity in swollen and unswollen polymer networks characterized by explicitly non-Gaussian distribution functions (Laplace's, Cauchy's, and continuous Poisson's in the exponential limit). An important outcome is the derivation of new families of statistical and mechanical laws, including a discussion of energy functions of strain invarian

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Context: Rapid growth has been suggested to promote islet autoimmunity and progression to type 1 diabetes (T1D). Childhood growth has not been analyzed separately from the infant growth period in most previous studies, but it may have distinct features due to differences between the stages of development. Objective: We aimed to analyze the association of childhood growth with development of islet

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C4b-binding protein (C4BP) is a well-known regulator of the complement system that holds additional and important activities unrelated to complement inhibition. Recently, we have described a novel immunomodulatory activity in the minor C4BP(β-) isoform directly acting over inflammatory phagocytes. Here we show that incorporation of the β-chain to the C4BP α-chain oligomer interferes with this immu

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In 2013, Mexico was the first developing country to adopt a carbon tax, confounding expectations that adoption of such taxes is mostly driven by international commitments and hindered by economic concerns: Mexico was not subject to international climate commitments and constituted an economy dependent on oil and exports to its NAFTA trading partners, which did not price carbon. To address this puz

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Multiple sclerosis (MS) is a chronic neurological disease believed to be caused by autoimmune pathogenesis. The aetiology is likely explained by a complex interplay between inherited and environmental factors. Genetic investigations into MS have been conducted for over 50 years, yielding >100 associations to date. Globally, the strongest linkage is with the human leukocyte antigen (HLA) HLA-DRB5*0

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Sammanfattning Marknadsföring är ständigt föränderlig och kräver hela tiden utveckling för att utmana konsumenter. Genom de första bloggarna, skapades en ny marknadsföringsportal som var mer genomträngande än traditionell reklam. Från detta utvecklades influencer-marketing, alltså marknadsföring via sociala medier. Näringsidkare kan använda en influencers plattform som kan en katalysator för ett Abstract Marketing is continuously changing and requires constant development to challenge consumers. Through the first blogs, a new marketing portal was created that was more penetrating than traditional advertising. From this, influencer marketing, i.e. marketing through social media, developed. Businesses can use an influencers platform as a catalyst for a commercial message, where, in additio

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This essay examines representations of extinction in a selection of Anthropocene fiction. The Anthropocene is a potential new geological epoch, in which the human species capacity for massive ecological transformation is rivalling that of geologic processes. As the Anthropocene has grown into a subject of cultural significance, critical literary scholarship has identified implications for a possib

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Introduction: International cooperation is essential for public health, as countries need to access medical equipment, combat health crises, and strengthen health capacities. Medical Diplomacy is a concept and practices that combines the goals of improving intergovernmental relations and health, by initiating and facilitating intergovernmental health cooperation. Objectives: This study specificall

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Many cities are facing the problem of old industrial areas whose soil has been contaminated with toxic substances created by different historical activities within the area. The great unsolved environmental problems, such as: water, soil and air pollution prob- lems, and habitat loss in the Öresund region today, are a result of the industrialization era. “Reclaiming Eco-Assemblages” lays out a m

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Publicerade våldtäktsanklagelser på sociala medier och ett icke-involverat rättsväsende blev karaktäriserande fenomen för Me Too-Rörelsen. Exemplifierat genom två huvudexempel hävdas avsaknaden av judiciell inblandning innebära ett ifrågasättande av antagandet att lagen styr staten, vilket i förlängningen argumenteras utgöra avsteg från Rättsstatsprincipen. Rättsstatsprincipen framhålls som grundPublishing rape allegations on social media whilst not involving the administration of justice became a significant phenomenon in the wake of the Me Too-Movement. Exemplified through two prime examples, the judicial un-involvement, arguably a questioning of the assumption that the law is the powerholder in the state, will be claimed to have been a departure from the concept of the Rule of Law. T

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OECD delivered on October 5th 2015 the BEPS final package consisting of 15 actions intending to address the issues of base erosion and profit shifting. The aim of Action 6 is to prevent treaty abuse, in particular treaty shopping. To achieve this goal, a specific anti- abuse rule, a Limitation- on- Benefit (LOB) rule, will be included in the OECD Model. The LOB rule contains objective tests that t

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This study explores the employment relationship, working conditions, and work-family relations of part-time domestic workers in Dhaka, Bangladesh. The aim of this study is to generate knowledge regarding part-time domestic workers, and to add to the broader literature available on domestic workers in Bangladesh. This thesis applies a qualitative case study method to gain in-depth knowledge and liv

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Prior to the accomplishment of this research, the compatibility of the classic e-servicescape conceptual model in the context Taobao and TMall in China were rarely found among existing e-servicescape literatures due to the standardization taken by both online platforms towards the establishment of individual webshops. Meanwhile, the conceptualization of social factors as social dimension of e-serv

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Title: Using scenarios to balance future requirements and capability development Author: Erik Jacobsson Division: Production Management Supervisors: Bertil Nilsson at the Technical Faculty of Lund University, Innovation Advisor at the case company Keywords: Scenarios, Corporate development, Energy Sector, Capabilities, Technology Background: The speed of change in the world is ever increasing

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The genetics underlying bird migration have been the subject of several studies. Two willow warbler subspecies (Phylloscopus trochilus trochilus and Phylloscopus trochilus acredula) follow different routes during their winter migration to Africa. Their breeding territories overlap in a contact area or “migratory divide” across central Scandinavia and to the east of the Baltic sea. Previous genome-

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Ectomycorrhizal fungi (EMF) mediate nutrient exchange between trees and soil in coniferous forests. Nitrogen (N) currently limits net primary productivity (NPP) in many terrestrial ecosystems but N deposition may alleviate this limitation, inducing limitation of phosphorous (P) instead. Studies have shown reductions in production of EMF mycelia (EMM) when trees are alleviated limitation of N, unle

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This study explores the extent to which decentralization has affected farmers’ access to agricultural advisory services in the Sunyani Municipality of Ghana. Specifically, it focuses on how political and organizational factors, which are intermediate outcomes of decentralization, affect the availability and relevance of advisory services. The study follows a qualitative research design employing q

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Moisture is decisive for a large number of binding and transport processes in high performance concrete affecting the durability, shrinkage and performance in various envi-ronments. An experimental study on the moisture transport properties of 20 concrete mixes was made during seven years, with type of binder, additives and water-binder ratio as parameters. An upside-down glass cup method was used