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Cardiovascular disease is the global number one causeof mortality and morbidity. The majority of cardio vascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is characterized by the formation of atherosclerotic plaques throughout the arterial tree. Over the years, insights intohe pathogenesis of atherosclerosis ha
Purpose of review Myocardial infarction survivors are at a high risk of a recurrent event despite receiving guideline preventive therapy. There is accumulated evidence that persistent atherosclerotic plaque inflammation contributes to this risk. Oxidized low-density lipoprotein (LDL) is widely recognized as a key factor in plaque inflammation and instability; however, no therapies that directly ta
The polar lipids in oat grains are crucial due to their biological functions, nutritional quality, potential use in food flavour and processing, the protection they provide against biotic and abiotic stresses, and their ability to act as cellular signalling molecules. In this study, we present novel findings about the impacts of fertilization and field management on oat polar lipid and fatty acid
Incubation temperature affects both growth and energy metabolism in birds after hatching. Changes in cellular mechanisms, including mitochondrial function, are a likely but unexplored explanation for these effects. To test whether temperature-dependent changes to mitochondria may link embryonic development to the post-natal phenotype, we incubated Japanese quail eggs at constant low (36.0°C), medi
OBJECTIVES: This is a protocol for a Cochrane Review (prototype). The objectives are as follows: Primary objective To determine the prognostic value of birth weight (BW) and prematurity in predicting the incidence of type 2 diabetes mellitus (T2DM) later in life (among adults, adolescents, and children) compared to normal BW and full-term birth. Secondary objectives To determine the prognostic val
Background: The impact of air pollution and road traffic noise on depression remains inconclusive. This study examined long-term residential exposure to air pollutants and road traffic noise in relation to dispensed antidepressant medications. Methods: A cohort study was conducted using the Swedish Malmö Diet and Cancer Study, with the outcome defined as a first dispensed antidepressant (ATC: N06A
BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock
Determining the drivers of intraspecific variation in cognitive performance is crucial for understanding how cognition evolves, but experimental studies are scarce. Several correlational studies have supported the hypothesis that living in larger groups enhances cognitive performance. However, empirical explanations of whether and how living in large groups causally affects individual cognitive pe
Two scales of gold mining operations, artisanal and small-scale mining (ASM) and large-scale mining, have operated side by side in Ghana for decades. In the past, the two co-existed on the same mineralised land without much contact or conflict, as large-scale mining occurred underground and ASM operated mainly on the surface. With the former's transition from an underground labour-intensive mining
Background: Ventricular fibrillation (VF) during acute ischemia is linked to increased dispersion of ventricular repolarization (DOR), which is considered a robust marker of arrhythmic susceptibility. In previous works, we showed that a time-warping-based index quantifying morphological changes from the T-wave peak to the T-wave end over a PCA transform lead, dPCAw,Tpe, outperformed the T-peak-to-
Popular Abstract in Swedish Trälimfogar är en väsentlig del av modern träkonstruktionsteknik. För att höja förädlingsvärdet hos träråvaran, tillverkas idag flera olika sorters produkter vilka är beroende av limfogar. Exempel på sådana produkter är limträ och fanerträ (LVL). Ett annat exempel där limfogar används är vid inlimning av skruvar eller stänger för sammanfogning eller förstärkning av limtThis thesis, which is a compilation of seven papers, concerns the mechanical testing, numerical analysis and constitutive modelling of wood-adhesive bonds in timber engineering. Applications such as finger-joints, glued-laminated timber and glued-in rods are considered. The experimental studies include the testing of the fracture characteristics of wood-adhesive bonds, including both wood-to-wood
Object. Subarachnoid hemorrhage (SAH) results in the expression of inflammatory and extracellular matrix (ECM)related genes and various G protein-coupled receptors. In the present study, the authors evaluated the time course and sequence of the transduction pathways, p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase-1 and 2 (ERK1/2), and associated transcription
Objective. To investigate the geographical variation in prostate cancer incidence in Sweden, in particular the incidences of screening-detected tumours and curative treatment of prostate cancer. Material and methods. Data were retrieved from the National Prostate Cancer Register of Sweden for all cases of prostate cancer diagnosed in the year 2000-01. There were a total of 14 376 cases of prostate
AIM: To study hemodynamic and blood oxygenation changes in patients undergoing carotid endarterectomy (CEA) under general (GA) or locoregional (LRA) anesthesia. METHODS: Prospective non-randomized study including 50 patients undergoing CEA (31 men, mean age 72 (range 50-84) years-old under GA (N.=23) or LRA (N.=27). Systemic blood pressure, ECG, venous oxygen saturation in the ipsilateral jugular
BACKGROUND: Clinical guidelines seldom provide in depth information about the most suitable type and intensity of exercise to obtain optimal benefit in different subgroups of T2D individuals. The aim of this study was to examine the effect of group exercise training on exercise capacity, insulin sensitivity and HbA1c in women with diabetes. METHODS: Twenty-two women with T2D participated in a supe
Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the bra
