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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193069 hits

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The MoCu CO dehydrogenase enzyme not only transforms CO into CO2 but it can also oxidise H2. Even if its hydrogenase activity has been known for decades, a debate is ongoing on the most plausible mode for the binding of H2 to the enzyme active site and the hydrogen oxidation mechanism. In the present work, we provide a new perspective on the MoCu-CODH hydrogenase activity by improving the in silic

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Agricultural land use is a major driver of biodiversity losses and changes in ecosystem services. Thus, for the sake of both humans and wild organism per se, effective strategies that enable both agricultural production and conservation of biodiversity and ecosystem services are urgently needed. Such strategies can be divided into those that reduce the intensity of farming in general (such as orga

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Recurrent circuitry components are distributed widely within the brain, including both excitatory and inhibitory synaptic connections. Recurrent neuronal networks have potential stability problems, perhaps a predisposition to epilepsy. More generally, instability risks making internal representations of information unreliable. To assess the inherent stability properties of such recurrent networks,

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A deep understanding of the Milky Way galaxy, its formation and evolution requires observations of huge numbers of stars. Stellar photometry, therefore, provides an economical method to obtain intrinsic stellar parameters. With the addition of distance information - a prospect made real for more than a billion stars with the second Gaia data release - deriving reliable ages from photometry is a po

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Background: Health-related illnesses such as obesity and diabetes continue to increase, particularly in groups of low socioeconomic status. The increasing cost of nutritious food has been suggested as an explanation. Objective: To construct a price index describing the cost of a diet adhering to nutritional recommendations for a rational and knowledgeable consumer and, furthermore, to investigate

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Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition

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Innovation in retailing is under-investigated in academia and yet a highly relevant concern given the current changes in the retail landscape. Although retailing is often characterized by a dynamic and highly competitive environment, retail organi- zations are not often considered as ‘innovative,’ at least when compared with manufacturing industries, or when using exist- ing innovation frameworks

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Gene therapy has been suggested as a plausible novel approach to achieve seizure control in patients with focal epilepsy that do not adequately respond to pharmacological treatment. We investigated the seizure-suppressant potential of combinatorial neuropeptide Y and Y2 receptor single vector gene therapy based on adeno-associated virus serotype 1 (AAV1) in rats. First, a dose-response study in th

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BACKGROUND: With increased participation in Paralympic sports, the burden of sports-related injuries and illnesses may increase. However, there is limited knowledge about the epidemiology of sports-related injuries and illnesses in Paralympic sports (SRIIPS).OBJECTIVE: To describe among Swedish Paralympic athletes the 1-year retrospective period prevalence of severe SRIIPS and the point prevalence

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BACKGROUND: Screening for abdominal aortic aneurysm (AAA) in elderly men reduces aneurysm related mortality. AAA is commonly defined as an infrarenal aortic diameter (IAD) of ≥30 mm, which is based on the definition of an arterial aneurysm as a focal dilation of 150% or more compared to the expected diameter of about 20 mm. The IAD has been shown to correlate to body surface area (BSA). The aim of

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Acute myeloid leukemia (AML) is defined by an accumulation of immature myeloid blasts in the bone marrow. To identify key dependencies of AML stem cells in vivo, here we use a CRISPR-Cas9 screen targeting cell surface genes in a syngeneic MLL-AF9 AML mouse model and show that CXCR4 is a top cell surface regulator of AML cell growth and survival. Deletion of Cxcr4 in AML cells eradicates leukemia c

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Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution s

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Mineral evolution is concerned with the timing of mineral occurrences, such as the earliest reported occurrences in the geologic record. Minerals containing essential Li have not been reported from rocks older than ca. 3000 Ma, thus the lithian tourmaline (fluor-elbaite) and mica (lepidolite) assemblage from a pegmatite near Zishineni associated with the ca. 3000 Ma Sinceni Pluton presents unusual

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Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previo

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A recent review by Lindskog & Young (2019) of a paper published in Lethaia by Bergström et al. (2018a) contains many errors, misleading statements and unsupported opinions. Their review claims that we did not consider biostratigraphy in our efforts to chemostratigraphically date the Winneshiek Shale. That this is incorrect is shown by the fact that Liu et al. (2017), which contains a two-page

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Detection and classification of distresses is a fundamental activity in the road pavement management. Even in the early stages of deterioration, road pavement needs to be monitored to identify problems, evaluating the actual conditions and predicting what the future conditions will be. Monitoring activities through manual/visual inspections are time consuming, costly and cause of safety concerns.

Campusgruppen 20250604 Minnesant

Utvecklingsenheten Postadress Campus Helsingborg Box 882, 251 08 Helsingborg Besöksadress Universitetsplatsen 2, 252 25 Helsingborg Telefon, 042-35 65 19, 042- 35 65 00 (växel) E-post carola.fors@ch.lu.se Webbadress www.ch.lu.se 1 (5) Minnesanteckningar från Campusgruppsmöte 2025-06-04 Närvarande: Magnus Adenskog Utvecklingsenheten Julia Luttrup Utvecklingsenheten Nina Smiseth Biblioteket Petra La

https://www.ch.lu.se/internt/sites/ch.lu.se.internt/files/2025-06/Campusgruppen%2020250604%20minnesant.pdf - 2026-07-22

Eaeut

EAEUT_20 1 Programme Syllabus for Master Programme in Economic Development and Growth 1. Identification Name of programme Economic Development and Growth (master programme) Ekonomisk utveckling och tillväxt (masterprogram) Scope of programme 120 ECTS Level Master level Programme code EAEUT Decision details 24 January 2020 2. Programme description There is an expanding demand by private and public

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-02/eaeut.pdf - 2026-07-22

No title

PAX Good Behavior Game är ett strukturerat program som syftar till att skapa ökad studiero. PAX har visat sig ha positiv inverkan på elevers beteenden i klassrummet liksom mer långsiktiga konsekvenser som minskad frekvens av hälsoskadliga aktiviteter i vuxenlivet. För att programmet ska få önskad effekt är kvaliteten i implementeringen och det fortsatta vidmakthållandet centralt. Trots detta finnsPAX Good Behavior Game is a structured program aiming to create a calmer learning environment. PAX has been associated positively with classroom behaviors and long-term effects such as decreased harmful behaviors in adulthood. The quality of implementation and sustainment is central for attaining desired outcomes. However, previous research on the principals’ experiences of implementation and sust