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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193054 hits

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In recent years evidence has emerged that the amount of isoprene emitted from a leaf is affected by the CO2 growth environment. Many - though not all - laboratory experiments indicate that emissions increase significantly at below-ambient CO2 concentrations and decrease when concentrations are raised to above-ambient. A small number of process-based leaf isoprene emission models can reproduce this

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Perseid and sporadic meteor hourly rates and magnitudes observed in 1953-1983 by a team of visual observers at the Onsala Space Observatory, Sweden, are analysed. A high-resolution study of the zenithal hourly rates of bright Perseid meteors /(m<=2.5) versus solar longitude has been made using a step length of /0.05° in solar longitude. The present study, which is based on 147 Perseid hourly rates

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The Boston Psychiatric Rehabilitation Approach (BPR) is person-centered and characterized by being based entirely on the individual's unique needs and preferences in the areas of working, learning, social contacts, and living environment. Nevertheless, the person-centered approach is lacking firm evidence regarding outcomes, and empirical studies regarding clients' experiences of this particular m

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Hemicelluloses extracted from wheat bran can be concentrated and purified by ultrafiltration. However, the viscosity of the process solution is rather high (about 5 mPa s at 80 C and a shear rate of 100 s1), which results in a relatively low flux. The solution was subjected to heat pretreatment in an attempt to decrease the viscosity and increase the flux. Pretreatment of the solution at 80 C for

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GPRC5B is an orphan receptor belonging to the group C family of G protein-coupled receptors (GPCRs). GPRC5B is abundantly expressed in both human and mouse pancreatic islets, and both GPRC5B mRNA and protein are up-regulated 2.5-fold in islets from organ donors with type 2 diabetes. Expression of Gprc5b is 50% lower in islets isolated from newborn (<3 weeks) than in adult (>36 weeks) mice. Lentivi

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Low-grade inflammation has been repeatedly associated with cardiovascular diseases but the relationship with incidence of atrial fibrillation (AF) remains unclear. We explored the association between elevated plasma levels of inflammation-sensitive proteins (ISPs) and incidence of AF in a population-based cohort. Plasma levels of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α(1)-antitrypsin

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Aims/hypothesis We aimed to identify which surrogate index of insulin sensitivity has the strongest correlation with the reference measurement, the hyperinsulinaemic-euglycaemic clamp (HEC), to determine which surrogate measure should be recommended for use in large-scale studies. Methods A literature search (1979-2012) was conducted to retrieve all articles reporting bivariate correlations betwee

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Context: It is an enigma that agile projects can succeed ‘without requirements’ when weak requirements engineering is a known cause for project failures. While agile development projects often manage well without extensive requirements test cases are commonly viewed as requirements and detailed requirements are documented as test cases.Objective: We have investigated this agile practice of using t

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OBJECTIVE Plasma metabolites that distinguish isolated impaired glucose tolerance (iIGT) from isolated impaired fasting glucose (iIFG) may be useful biomarkers to predict IGT, a high-risk state for the development of type 2 diabetes. RESEARCH DESIGN AND METHODS Targeted metabolomics with 23 metabolites previously associated with dysglycemia was performed with fasting plasma samples from subjects w

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Fatigue performance under axisymmetric push-pull loading of a magnesium alloy Mg-6Zn-0.5Zr (ZK60) after processing by integrated extrusion and equal-channel angular pressing was investigated. Such processing was shown to nearly treble the endurance limit of the alloy, raising it to 160 MPa. It was established that the high-cycle fatigue performance of ZK60 is primarily controlled by dislocation su

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In the present paper combustion of micron-sized aluminum dust cloud has been studied in a quiescent reaction medium with spatially discrete sources. A new thermal model is generated to estimate the flame front speed in a lean reaction environment in different oxidizer concentrations. Different burning time models for aluminum are utilized in the generated thermal model to compare their applicabili

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Anaphylaxis/anaphylactoid reactions have recently been reported after few treatments with factor IX concentrates in patients with haemophilia B at the same time as inhibitors to factor IX were demonstrated. In some of these cases nephrotic syndrome has appeared during immune tolerance induction (ITI) with high doses of factor IX concentrates. Gene deletions seem to be associated with a high risk o

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PURPOSE OF THE REVIEW: The controversies surrounding perioperative antimicrobial prophylaxis (AMP) are about the use and especially misuse of antibiotics. The overall lack of evidence to facilitate a rational perioperative AMP policy in urological surgery and the postoperative infectious complications remain a challenge. Therefore, a basic tool to aid decision-making would be useful. A model based

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According to the standard story given by reductive versions of the Causal Theory of Action, an action is an intrinsically mindless bodily movement that is appropriately caused by an intention. Those who embrace this story typically take this intention to have a coarse-grained content, specifying the action only down to the level of the agent’s habits and skills. Markos Valaris (2015) argues that,

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We outline a conceptual strategy for implementing conservation interventionsin a multiscale, multiactor, and multilevel governance world. Using farmlandas an example, we argue that conservation interventions should be implementedwithin a multiscale framework of guiding ecological principles. Inthis context, findings from multilevel governance research can inform a nuancedunderstanding of the role