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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114793 hits

Phase retrieval using the Hessian operator

Phase retrieval is a fundamental problem in optics, particularly in ptychography, where reconstructing an unknown wavefield from intensity-only measurements poses significant computational challenges. In this work, we introduce a novel phase retrieval method using the bilinear Hessian and Hessian operator to improve optimization efficiency. By formulating the problem in a differential calculus fra

Longitudinal outcome prediction of prostate cancer patients on active surveillance using multiple instance learning

Purpose: To avoid over-treatment of prostate cancer patients following screening for elevated prostate-specific antigen levels, keeping patients on active surveillance has been suggested as an alternative to radical treatment. This means recurring visits for patients with low-grade cancer to monitor progression. Our aim was to develop an artificial intelligence-based model that can identify high-r

The Quebec classification and a new Swedish classification for whiplash-associated disorders in relation to life satisfaction in patients at high risk of chronic functional impairment and disability

Unlike the Quebec classification system, which is based primarily on pathoanatomy, a new Swedish classification system is based on the site of functional impairment and disability. A prospective study was performed on 85 patients with whiplash-associated disorders grade II according to the Quebec classification. The patients were examined 3-36 months following trauma. A team of professionals with

A chemotaxonomic method for classification of asymmetric Penicillia by means of cross-partition in aqueous 2-phase systems combined with simca pattern-recognition analysis

A chemotaxonomic method for classification of asymmetric penicillia by means of cross-partition in aqueous two-phase systems combined with SIMCA pattern recognition analysis. Conidia of three strains each of three closely related Penicillium species in the P. oiridicatum group were subjected to cross-partition in aqueous polymer two-phase systems. The cross-point values, the percentage of conidia

Making Manufacturing Flexibility Operational Part 2 - Distinctions and an Example

Structures the concept of flexibility by making clear distinctions in three generic dimensions, describes the use of the framework for manufacturing flexibility by working through a concrete example. The framework was presented in “Making manufacturing flexibility operational – part 1: a framework”, IMS, Vol. 6 No. 2. Makes distinctions between the concept of flexibility in the three generic dimen

Kommisionen på krigsstigen - En rättsanalys av kommissionens tillämpning av statsstödsreglerna i skattemål

Att multinationella koncerner ägnar sig åt aggressiv skatteplanering har under det senaste decenniet blivit en självklarhet. De kan genom att utnyttja olikheter i ländernas skattelagstiftning planera sin beskattning och allokera kostnader till ett högskatteland och intäkter till ett lågskatteland för att på så vis behålla en större del av vinsten inom koncernen. Det har uppdagats i flertalet journThe fact that Multinational enterprises (hereinafter only referred to as MNE's) engage in aggressive tax planning has become a matter of course in the last decade. This is usually possible due to the fact that they are active in many countries. By exploiting differences in the tax law of the different countries in which they operate they can plan their taxation in order to retain a greater pro

Test Scheduling for 3D Stacked ICs under Power Constraints

This paper addresses Test Application Time (TAT) reduction for core-based 3D Stacked ICs (SICs). Applying traditional test scheduling methods used for non-stacked chip testing where the same test schedule is applied both at wafer test and at final test to SICs, leads to unnecessarily high TAT. This is because the final test of 3D-SICs includes the testing of all the stacked chips. A key challenge

Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide

Popular Abstract in Swedish Människor och djur utsätts ständigt för sjukdomsalstrande virus, bakterier och parasiter som finns i vår omgivning. Som skydd mot dessa har vi utvecklat ett immunförsvar. Detta har till uppgift att känna igen och eliminera dessa främmande, sjukdomsalstrande organismer (patogener), medan frisk, kroppsegen vävnad inte känns igen av immunsystemet. Immunsystemet består av kThe aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. TNF-a is produced from the ear

eavesROP: Listening for ROP Payloads in Data Streams (preliminary full version)

We consider the problem of detecting exploits based on return-oriented programming. In contrast to previous works we investigate to which extent we can detect ROP payloads by only analysing streaming data, i.e., we do not assume any modifications to the target machine, its kernel or its libraries. Neither do we attempt to execute any potentially malicious code in order to determine if it is an att

New approach to steroid separation based on a low affinity IgM antibody

IgM antibodies are often of low affinity (dissociation constant (K(d)) > 10-5 M) and therefore they are usually neglected as tools in, e.g., immunoassays. Previous studies have shown that low affinity biological interactions can be studied and exploited in affinity chromatography, biosensor technology and capillary electrophoresis. In this study we have demonstrated that IgM can be a useful ligand

Quasi diabatic CASSCF state functions

A new method to determine quasi diabatic (QD) CASSCF states is presented. The adiabatic states are subjected to a unitary transformation resulting from diagonalization of a state-selection operator. The latter is constructed from the overlap of the adiabatic states with a suitable set of reference states. The multi-state (MS) CASPT2 method is used to account for the dynamical correlation effects i

Personal factors in systemic sclerosis and their coverage by patient-reported outcome measures

Background. Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients' background, experience and behavior which highlights the need to know if patient-reported outcome measures (PR

Towards accurate in vivo spectroscopy of the human prostate

The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in th

Climate Change Effects on Rainfall and Management of Urban Flooding

Popular Abstract in Swedish Översvämningar i städer ökar på grund av ökad urbanisering samt klimatförändringar och klimatvariabilitet. Denna avhandling presenterar effekterna av klimatförändringar och intensiv nederbörd i städer samt handhavandet av översvämning i urban områden i Mumbai, Indien och i Skåne samt Göteborg. En rad statistiska och analytiska verktyg har tillämpats för att studera nedeFlooding in urban basins is intensifying due to increasing urbanization and climate change and variability. This thesis presents how the effects of climate change and high-intensive rainfall on the urban drainage system and management of flooding in urban areas of were studied in Mumbai, India and Southern Sweden, including Skåne and Gothenburg. Various statistical and analytical tools were applie