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A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362)
Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asympto
Conventional views of the police support a norm of emotion management. Aspiring police officers are taught not to show pain or fear and to display an image of control and assertion. If failing to convey such emotions officers might be considered too weak or simply not “man enough” for the job. This is also the case concerning border guarding and border police conduct. This study draws on data gath
Because of the amphiphilic properties of alcohols, hydrophobic hydration is important in the alcohol-water system. In the present paper we employ X-ray photoelectron spectroscopy (XPS) to investigate the bulk and surface molecular structure of ethanol-water mixtures from 0.2 to 95 mol %. The observed XPS binding energy splitting between the methyl C 1s and hydroxymethyl C 1s groups (BES-[CH3-CH2OH
In a solid-state host, attractive electron-electron interactions can lead to the formation of local electron pairs which play an important role in the understanding of prominent phenomena such as high T c superconductivity and the pseudogap phase. Recently, evidence of a paired ground state without superconductivity was demonstrated at the level of single electrons in quantum dots at the interface
Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. However, long-term analysis of human iPS cell-derived dopaminergic neurons in primate PD models has never been performed to our knowledge. Here we show that human iPS cell-derived dopaminergic progenitor cells
In order to meet the requirements in the stringent emission regulations, more and more research work has been focused on homogeneous charge compression ignition (HCCI) and partially premixed combustion (PPC) or partially premixed compression ignition (PCCI) as they have the potential to produce low NOx and soot emissions without adverse effects on engine efficiency. The mixture formation and charg
This work presents a 2.0mm2 128×16 massive MIMO detector IC that provides 21dB array gain and 16x multiplexing gain at the system level. The detector implements iterative expectation-propagation detection (EPD) for up to 256-QAM modulation. Tested with measured channel data [1], the detector achieves 4.3dB processing gain over state-of-the-art massive MlMo detectors [2, 3], enabling 2.7x reduction
Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC proteins are crucial in pathogen recognition, it is still poorly understood how pathogen-mediated selection promotes and maintains MHC diversity, and especially so in host species with highly duplicated MHC genes. Sedge wa
During a recent measurement campaign, we encountered some problems in extracting the rice factor from measurements. There were different answers to the question of what constitutes the correct line-of-sight component. This document highlights those issues and is meant to be a basis of discussion. Any feedback on the raised issues is welcome.
The focus of this work is detecting pedestrians, captured in a surveillance setting, and locating them in world coordinates. Commonly adopted search strategies operate in the image plane to address the object detection problem with machine learning, for example using scale-space pyramid with the sliding windows methodology or object proposals. In contrast, here a new search space is presented, whi
From an environmental perspective, a separate collection and recycling system for post-consumer discards could contribute to improved environmental protection as well as economic benefits. This paper investigates the environmental potential of a business model proposed in Sweden in order to improve the utilization of plastic shopping bags. The business model aims to reduce the consumption of plast
Security has been recognized as a leading barrier for IoT adoption. The growing number of connected devices and reported software vulnerabilities increases the importance firmware updates. Maturity models for software security do include parts of this, but are lacking in several aspects. This paper presents and evaluates a maturity model (HAVOSS) for handling vulnerabilities in third party OSS and
Background: The "Valentino" cross-sectional study is aimed at evaluating the prevalence and pattern of cigarette smoking according to occupational group in a representative sample of workers aged 18-35 years from Abruzzo, Italy. Methods: Randomly selected workers anonymously self-compiled a structured questionnaire containing validated items. Job type was coded according to the International Stand
