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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193125 hits

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This study aims at investigating the occurrence and characteristics of drought patterns by analyzing a 238-year long monthly precipitation time sequence observed at Lund in Sweden using an ordinary Kalman filter (OKF) and an adaptive Kalman filter (AKF). The OKF identifies the periods (in the time sequence) with anomalous precipitation by comparing the observed and average precipitation patterns.

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A reconstructed human epidermis (RHE) model, the EpiDerm, was investigated and compared to human skin ex vivo regarding tissue penetration and distribution of two chromium species, relevant in both occupational and general exposure in the population. Imaging mass spectrometry was used in analysis of the sectioned tissue. The RHE model gave similar results compared to human skin ex vivo for skin pe

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The European Congenital Heart Surgeons Association (ECHSA) Congenital Database (CD) is the second largest clinical pediatric and congenital cardiac surgical database in the world and the largest in Europe, where various smaller national or regional databases exist. Despite the dramatic increase in interventional cardiology procedures over recent years, only scattered national or regional databases

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In this article, hesitancy towards COVID-19 vaccinations is investigated as a phenomenon touching upon existential questions. We argue that it encompasses ideas of illness and health, and also of dying and fear of suffering. Building on a specific strand within anti-vaccination studies, we conjecture that vaccine hesitancy is, to some extent, reasonable, and that this scepticism should be studied

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The European Congenital Heart Surgeons Association (ECHSA) Congenital Database (CD) is the second largest clinical pediatric and congenital cardiac surgical database in the world and the largest in Europe, where various smaller national or regional databases exist. Despite the dramatic increase in interventional cardiology procedures over recent years, only scattered national or regional databases

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A producer-independent, problem-oriented, group-education programme with 2-day meetings on drug treatment in primary health care (PHC) was developed and evaluated. Initially, it was tested on a selected group of general practitioners (district physicians), using a non-exposed group as control. A comprehensive questionnaire was used to test changes in attitudes. There was a significant change in at

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Capsazepine is known as a transient receptor potential channel vanilloid subfamily 1 (TRPV1) antagonist that inhibits bronchoconstriction evoked in animals by TRPV1 agonists. In this study, effects of capsazepine and chemically related analogues, so called capsazepinoids, were examined in vitro on contractile effects in human small airway preparations. Repeated cycles with 1 h of LTD4-free physiol

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This paper deals with the contemporary concern of business service-orientation. The paper suggests that service-oriented Business Information Systems Development (BISD) permits quality aspects, -“ilities” e.g.; maintainability and modifiability, of BISs and BISD. In addition, this paper departs from viewing a Business Information System (BIS) as services and suggests Separation of Concerns (SoC) a

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The C2H2(+H)/Pd(111) system has been studied using high resolution core level spectroscopy and low energy electron diffraction (LEED). Two ordered phases were found when adsorbing C2H2 at 125 K, giving rise to a (2 × 2) and a (√3 × √3)R30° LEED pattern, respectively. When preadsorbing H at 110-150 K, the sticking probability of the C2H2 molecules is strongly reduced and only the (√3 × √3)R30° over

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A Report prepared for The European Alliance of Listeners’ and Viewers’ Associations (EURALVA)

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Energy distributions of slow electrons (0-10 eV) emitted by thin layers of NaCl, KBr, CsBr, and CsI irradiated by monochromatic XUV photons with various energies in the interval of 50-300 eV are measured. The contributions of slow secondaries, hot secondaries and primary photoelectrons are obtained. It is shown that the higher the absorption coefficient for incident photons, the stronger the contr

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A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi

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Drawing on the concept of a “complex humanitarian crisis,” this paper describes how outflows of migrants from Central America were transformed into such a crisis by intransigent immigration and border policies enacted in both Mexico and the United States. We describe the origins of the migration in U.S. Cold War interventions that created many thousands of displaced people fleeing violence and eco

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Multiple trade-offs likely occur between pesticide use, pollinators and yield (via crop flowers) in pollinator-dependent, mass-flowering crops (MFCs), causing potential conflict between conservation and agronomic goals. To date, no studies have looked at both outcomes within the same system, meaning win-win solutions for pollinators and yield can only be inferred. Here, we outline a new framework

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Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy and by helping them adapt to a variety of environmental stressors. This state is the result of aneuploid cancer cells undergoing whole genome doubling and skippi

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The investigation is concentrated on two important quantities – the Strouhal number and the mean base suction coefficient, both measured at the mid-span position. Reynolds numbers from about 50 to 4 × 104 were investigated. Different aspect ratios, at low blockage ratios, were achieved by varying the distance between circular end plates (end plate diameter ratios between 10 and 30). It was not pos