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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192816 hits

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The Kernel Density Estimator (KDE) is a versatile nonparametric technique with very good theoretical properties. It is used to obtain "smoothed histograms," which allows several distributions to be presented and analyzed more easily on one graph, and direct combination into average distributions. The application of the KDE method as a visual aid for the analysis of distributions of muscle fiber ar

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The major myeloid blood cell lineages are generated from hematopoietic stem cells by differentiation through a series of increasingly committed progenitor cells. Precise characterization of intermediate progenitors is important for understanding fundamental differentiation processes and a variety of disease states, including leukemia. Here, we evaluated the functional in vitro and in vivo potentia

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Simulations with the Explicit Microphysics Model (EMM) of a case of lightly precipitating, glaciated stratiform cloud are presented. This frontal cloud was observed by the UK Met Office C-130 aircraft and the dual-polarization radar at Chilbolton in southern England. The Hallett-Mossop (H-M) process was found to cause extremely high number concentrations of crystal columns of up to almost 1000 1(-

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Box jellyfish, or cubomedusae (class Cubozoa), are unique among the Cnidaria in possessing lens eyes similar in morphology to those of vertebrates and cephalopods. Although these eyes were described over 100 years ago, there has been no work done on their electrophysiological responses to light. We used an electroretinogram ( ERG) technique to measure spectral sensitivity of the lens eyes of the C

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The Strategic Systemic Thinking (SST) framework is presented as a stepping stone towards enabling the refocusing of organizational analysis in Information Systems (IS). The paper introduces some of the fundamental assumptions regarding the objectives of the SST framework; such as sense making as learning processes build upon communicative actions. The main concepts of the SST framework are present

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In neural transplantation studies, there is an interest in identifying and isolating mesencephalic dopamine (mesDA) neuron precursors that have the capacity to differentiate into fully mature mesDA neurons after transplantation. We report here that in the developing ventral mesencephalon (VM) the proneural gene Neurogenin2 (Ngn2) is expressed exclusively in the part of the ventricular zone that gi

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Despite significant advances in the understanding and modelling of turbulent combustion, no general model has been proposed for simulating flames in industrial combustion devices. Recently, the increase in computational possibilities has raised the hope of directly solving the large turbulent scales using large eddy simulation (LES) and capturing the important time-dependant phenomena. However, th

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Purpose: The aim of the present study is to compare two different methods for evaluation of the quality of clinical X-ray images. Methods: Based on fifteen lumbar spine radiographs, two new sets of images were created. A hybrid image set was created by adding two distributions of artificial lesions to each original image. The image quality parameters spatial resolution and noise were manipulated a

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Studies focusing on genetic and social influences on maternal adjustment will illumine mother's marriage, parenting, and the development of psychopathology in her children. Recent behavioral genetic research suggests mechanisms by which genetic and social influences determine psychological development and adjustment. First, heritable, personal attributes may influence individuals' relationships wi

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Purpose. To evaluate treatment outcome with Zygoma fixtures (Nobel Biocare, Goteborg, Sweden) with regard to fixture survival, patient satisfaction, and function of prosthesis replacement. Materials and Methods: The treatment outcome of 76 patients treated with 145 Zygoma fixtures at 16 centers was evaluated. Patient's and dentist's evaluations of the functional and aesthetic outcome of the treatm

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The formation of cyclohexene in the hydrogenation of benzene on a ruthenium catalyst has been studied in a slurry reactor. The reaction was performed in an alkaline aqueous phase in a stirred autoclave of stainless steel. The influence of reaction parameters, e.g. hydrogen pressure, alkali concentration, amount of catalyst and temperature was determined. The influence of poisoning of the catalyst

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Popular Abstract in Swedish I september 1989 kom det till kanadensiska mi’kmaqindianers kännedom att ett enormt granitbrott (ett av de tre största i världen) planerades att öppnas vid Kellys Mountain på ön Cape Breton i östra Kanada. Mi’kmaqtraditionalister organiserade genast en fredlig trumceremoni på berget och en talesman deklarerade att det planerade granitbrottet var en förolämpning mot bådeThis dissertation seeks to explore historical changes in the lifeworld of the Mi’kmaq Indians of Eastern Canada. The Mi’kmaq culture hero Kluskap here serves as a key persona in discussing issues such as traditions, changing conceptions of land, and human-environmental relations. In order not to depict Mi’kmaq culture as timeless, two important periods in its history are examined. The first study

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The production fractions of charged and neutral b-hadrons in b-quark events from Z(0) decays have been measured with the DELPHI detector at LEP. An algorithm has been developed, based on a neural network, to estimate the charge of the weakly-decaying b-hadron by distinguishing its decay products from particles produced at the primary vertex. From the data taken in the years 1994 and 1995, the frac

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This paper describes an attempt to apply linear optimal control theory to computer control of an industrial process. The applicability of the theory is discussed. Particular attention is given to the problem of obtaining a mathematical model of process dynamics and disturbances. Results of actual measurements as well as results from on-line control experience are presented.

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Diagnosis by screening mammography is considered an independent positive prognostic factor, although the data are not fully in agreement. The aim of the study was to explore whether the mode of detection (screening-detected versus symptomatic) adds prognostic information to the St Gallen molecular subtypes of primary breast cancer, in terms of 10-year cumulative breast cancer mortality (BCM).

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PURPOSE:: To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis. METHODS:: A 25-year-old previously healthy female contact lens user was diagnosed with unilateral severe keratitis with unclear pathogenesis, although the clinical presentation suggested acanthamoeba as the infectious agent. A 4-mm diameter, annular, semi-opaque inf

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Introduction: Standard dosimetry methods for radionuclide therapies re- quire imaging at multiple time points post injection. An alternative method has been presented in the literature that uses previously acquired pharma- cokinetic data to create so-called dose factors. Multiplying the dose factors with an activity concentration (Bq/ml) taken from a single time point mea- surement results in an e