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Pleiotropy (multiple phenotypic effects of single genes) and epistasis (gene interaction) have key roles in the development of complex phenotypes, especially in polymorphic taxa. The development of discrete and heritable phenotypic polymorphisms often emerges from major-effect genes that interact with other loci and have pleiotropic effects on multiple traits. We quantified gene expression changes
High-speed imaging of fuel sprays and combustion is conducted on a light-duty optical engine to investigate the effects of injector aging, with a focus on soot. The spray behaviors of one new and one aged injector are compared using Mie-scattering. In addition to this, the combustion process of a baseline diesel fuel and a blend with TPGME (tripropylene glycol monomethyl ether) are compared using
Background and purpose — As previous studies indicate time trends in pediatric fracture incidence, we followed the incidence in a Swedish city between 1950 and 2016. Patients and methods — Malmö city, Sweden had 322,574 inhabitants in 2015. We used diagnosis registry, charts, and radiographs of the only city hospital to classify fractures in individuals < 16 years in 2014–2016, and compared these
Mammalian dihydroorotate dehydrogenase, the fourth enzyme of pyrimidine de novo synthesis is an integral protein of the inner mitochondrial membrane that faces the intermembrane space and is functionally connected to the respiratory chain via ubiquinone. Here, we describe the first cloning and analyzing of the complete cDNA of mouse dihydroorotate dehydrogenase. Based on our recent functional expr
BACKGROUND: Although tuberculosis accounts for the highest mortality from a bacterial infection on a global scale, questions persist regarding its origin. One hypothesis based on modern Mycobacterium tuberculosis complex (MTBC) genomes suggests their most recent common ancestor followed human migrations out of Africa approximately 70,000 years before present. However, studies using ancient genomes
Urbanization represents a fierce driver of phenotypic change, yet the molecular mechanisms underlying observed phenotypic patterns are poorly understood. Epigenetic changes are expected to facilitate more rapid adaption to changing or novel environments, such as our towns and cities, compared with slow changes in gene sequence. A comparison of liver and blood tissue from great tits Parus major ori
Trots att nationalistiska partier är mansdominerade och har en begränsande kvinnosyn lockar de till sig kvinnor. Tidigare försök att förklara detta fenomen har varit relationella eller strukturella på bekostnad av aktörsdrivna approacher. I den här uppsatsen genomför vi en intervjubaserad studie av kvinnor som representerar det nationalistiska partiet Sverigedemokraterna (SD) i skånska kommunfullm
In this thesis, issues surrounding climate actions are analysed through the notion of corporate due diligence in the European Union (EU) context. The study explores how mandatory climate change due diligence schemes, potentially in the form of a legally binding instrument, may affect the critical sector of energy-intensive industries (EIIs) in the Union and further contribute to the broader EU cli
Efficient and effective environmental information processing is a key element for the improvement of an organization‘s environmental performance. Business Information Systems (BIS) are recognized as a tool for the facilitation of collecting, storing, processing and communicating any kind of information. However, there are other benefits that BIS can provide for a company. These benefits are relate
Synthetic biomaterials used as bone graft extenders (BGE) in spinal fusion surgery can supplement but do not replace autologous bone. This pilot study evaluated a calcium sulfate/hydroxyapatite (CaS/HA) material as an antibiotic-eluting BGE and a carrier for bone morphogenetic protein-2 (BMP-2) in a rabbit posterolateral lumbar (L4–L5) spinal fusion model (PLF). Pre-set CaS/HA beads were loaded wi
Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG)n expansion. MJD has two major ancestral backgrounds: the Machado lineage, found mainly in Portuguese families; and the Joseph lineage, present in all five continents, probably originating in Asia. MJD has been described in a few African and African-American families, but here we report the fir
Over the centuries the Mayan indigenous population has been excluded from power politics in Guatemala. During the last decades much attention by scholars has been placed on the Mayan movement, as a new and unconventional political actor. In this study I examine why and how this actor has emerged, with specific consideration on the shift from class to culture. By drawing on theories of civil societ
The purpose of this thesis is to enrich our understanding of micro-level internal legal culture by examining how Indonesian legislative lawyers navigate tensions between legal principles and political pressures. The focus is on civil servants within the Coordinating Ministry for Human Development and Cultural Affairs who are tasked with law-making processes, such as drafting, negotiating, and
This thesis explores arguments and styles of argumentation in favour of Scotland gaining independence and rejoining the European Union in the aftermath of the United Kingdom leaving the EU in 2020. Since a majority of Scots did not support Brexit, it has provided Scottish independence supporters with a unique opportunity to bolster their arguments in the political debate. The thesis is built on a
iiAbstractThis thesis examines how women living in a women-only asylum shelter in Austria exercise agency in their daily lives amid institutional regulation, legal uncertainty, and prolonged waiting. It explores how residents organise their daily lives, cope with insecurity, and try to maintain a sense of control within institutional settings and social relationships. Agency is not understood as a
Background: The objective of this study was to explore the potential of Airspace Dimension Assessment (AiDA) to rapidly determine the type and severity of airway obstruction, detect emphysema in individuals with chronic airflow limitation (CAL), and distinguish it from non-emphysematous obstruction, asthma, and absence of respiratory disease with normal spirometry. Methods: Among the 744 participa
Objectives: The only treatment with curative potential for distal cholangiocarcinoma (dCCA) is radical surgery which can be complemented with adjuvant chemotherapy. The aim of the present study was to perform an independent external validation of a prognostic model for 3-year overall survival based on routine clinicopathological variables for patients treated with pancreatoduodenectomy for dCCA. M
