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Medical research generates a large number of publications with the PubMed database already containing >35 million research articles. Integration of the knowledge scattered across this large body of literature could provide key insights into physiological mechanisms and disease processes leading to novel medical interventions. However, it is a great challenge for researchers to utilize this informa
Background: TDP-43 proteinopathies represent a spectrum of neurological disorders, anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The ALS–FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes, highlighting its heterogeneity. This study was aimed to use disease progression modeling to identify nov
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno
Context. The TOI-178 system consists of a nearby late K-dwarf transited by six planets in the super-Earth to mini-Neptune regime, with radii ranging from -1.1 to 2.9 R and orbital periods between 1.9 and 20.7 days. All planets but the innermost one form a chain of Laplace resonances. Mass estimates derived from a preliminary radial velocity (RV) dataset suggest that the planetary densities do not
'Daniel Hjorth and Chris Steyaert set out to advance the study of entrepreneurship by refocusing the lens of discovery from economics, management and marketing to other paradigmatic stances in social sciences and humanities like anthropology and literary studies. The result is a provocative collection of chapters that inspire the reader to consider and explore new ideas and research practice that
Anthropocentrism and disciplinary research have not led to effective solutions to sustainability problems. A shift is required towards biocentric, transdisciplinarity-based solutions, to mitigate rebound effects and unintended, negative effects. In the field of Sustainable Supply Network Design, such shift implies on developing resilient solutions that maximize environmental benefits instead of mi
The concept of servitization has brought about a significant transformation in numerous industries, signaling a strategic shift from a focus on goods to a service-oriented perspective. With the ascent of “Games as a Service”, Service-dominant logic is highly relevant in understanding games as a service. where players emerge as co-creators of value, shaping their unique experiences and meaning in t
Ever since the establishment of the European Coal and Steel Community with the Paris Treaty in 1952, the European Union and its predecessors have been involved in public health policy. This study investigates the mechanisms driving public health policy integration within the European Union by posing the research question ‘Why does integration in the policy area of public health occur?’. Aligned wi
For many years, the United States’ inability to provide basic universal healthcare has been a mystery. Why does the richest country in the world not have the best healthcare and the best health outcomes? This study examines the disposition of US opposition to publicly funded healthcare. It is a qualitative case study comprised of articles from the right-wing media outlet Breitbart News during the
This thesis examines the effect of cognates on codeswitching in planned speech production in trilinguals, which has previously been unexplored. Previous studies on cognates and codeswitching have primarily focused on cognate facilitation effects in spontaneous speech in bilinguals. While experimental studies have gradually acknowledged the importance of investigating codeswitching in a sentence co
Antimicrobial resistance (AMR) is a growing problem worldwide as more drug-resistant bacteria are identified. However, resistance is comparably rare against antibiotics that target the cytoplasmic membrane. Membrane thickness is an important factor for the mode of action of these antibiotics, and difficult to study. Thus, constructing a biosensor to measure membrane thickness in vivo is of great i
Chemical waste from industrial processes poses a significant environmental challenge, often resulting from inefficient synthetic routes that involve excess reagents and ineffective methods. The principles of atom and step economy have become central to modern synthetic strategies, aiming to minimize waste and maximize molecular efficiency. In this context, photo-redox catalysis has emerged as a co
Purpose: Consumers are forming deep love relationships with brands to a degree that involves the incorporation of the brand’s symbolic attributes to their own self-concept. However, though deep, these bonds are not indestructible. With that said, this thesis aims to investigate the consumer-brand love relationship with specific regard to the dissolution of these deep bonds. Methodology: In-depth s
Problemdiskussion: Sektorn för olja och gas är inte särskilt mogen när det gäller kunskapen om försörjningskedjor. Det valda företaget för fallstudien, Maersk Drilling (MD), har problem med ett splittrat IT-landskap och dålig datakvalitet. Det har orsakat problem med ineffektiva och komplexa processer där det krävs onödig kommunikation, parallell inmatning av data, etc. Inom upphandlingar och inkProblem Discussion: The oil and gas sector is not very mature in terms of supply chain management. The chosen case company, Maersk Drilling (MD), has problems with a split IT-landscape with poor data quality. It has caused problems with inefficient and complex processes with much communication required, parallel information and more. Within procurement it translates to problems in spend managemen
