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Elongation factor G (EF-G) is a G protein factor that catalyzes the translocation step in protein synthesis on the ribosome. Its GTP conformation in the absence of the ribosome is currently unknown. We present the structure of a mutant EF-G (T84A) in complex with the non-hydrolysable GTP analogue GDPNP. The crystal structure provides a first insight into conformational changes induced in EF-G by G
Photophysical studies of pseudo-p-distyryl[2.2]paracyclophane, a model molecule of a stilbene dimer arranged in a brick-wall geometry, in tetrahydrofurane solution indicate the existence of at least two conformers in the ground state. The conformer A with the smallest optical gap of 3 eV has a short radiative lifetime of 3.3 ns, while the conformer B with an optical gap about 0.3 eV larger is much
A numerical study is performed to investigate the effects of various discrete rib configurations on the heat transfer and fluid flow characteristics of a rotating rectangular straight channel (aspect ratio of 2:1) with 45° orientation. Three parameters of the discrete rib configuration - rib streamwise distance, rib widthwise distance, and inner-half-rib angle - are examined based on a continuous
Incumbent firms face growing pressure to transform their business towards sustainability. However, business models for sustainability (BMfS) and circularity are grounded in fundamentally different institutional logic which, for incumbents, creates tensions with existing business models, structures and routines. How organizations manage tensions from conflicting logics is explored comprehensively i
Vocabulary experts recommend first language (L1) translation equivalents for establishing form–meaning mappings for new second language (L2) words, especially for lower proficiency learners. Empirical evidence to date speaks in favor of L1 translation equivalents over L2 meaning definitions, but most studies have investigated bi- rather than multilingual learners. In our study, we investigated ins
Focusing on welfare challenges and crises encountered by women in contemporary Vietnam, this article examines the gendering of morality and the ways in which a feminized ethics of care is entangled with women’s practice of the social capacity tình cảm (sentiments/feelings/emotions). Drawing on data from the Industrial Zones of northern Vietnam, the article highlights how low-income workers are ren
In the face of global climate change there is an increasing demand for biofuel, which exerts pressure on production and thus management of biofuel plantations. The intensification of whole-tree harvest from biofuel plantations increases export of nutrients. Returning ash from biofuel combustion to the forest plantations can amend the soil nutrient status and thus facilitate sustainable forest mana
We investigate the frequency stability of a high-order multi-converter system. For this, we identify its symmetry (i.e., rotational invariance) generated by a static angle shift and rotation of ac signals. We characterize the synchronous steady-state set, primarily determined by the steady-state angles, and dc power input. Based on eigenvalue conditions of its Jacobian matrix, we show asymptotic s
The study presented in this article is about the role played by imagination when national and international organisations convey the idea of a dystopian crisis involved in the real transition to a postantibiotic era. The present is an era that can be defined as a time when no new antibiotics are discovered or developed, and existing antibiotics simultaneously become less effective since bacteria d
Excerpt: "Just like the rest of the population, Swedish Christians remain fundamentally divided in their opinions about the best way to arrange Sweden’s relationship to NATO. But the responses on the part of the churches also seem to hark back to bygone ages. National defense and foreign policy remain, in a country for centuries fundamentally shaped by Lutheran doctrine concerning the division bet
As legislators and platforms tackle the challenge of suppressing hate speech online, questions about its definition remain unresolved. In this review we discuss three issues: What are the main challenges encountered when defining hate speech? What alternatives are there for the definition of hate speech? What is the relationship between the nature and scope of the definition and its operationabili
This paper presents the numerical results of combustion and soot recession in the Engine Combustion Network (ECN) Spray A and D flames using large eddy simulations (LES). The nominal injector nozzle diameters for the ECN Spray A and D are 90μm and 186μm. A two-equation soot model is implemented to model the soot formation and oxidation processes. The numerical model is validated by comparing the s
Introduction: Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention. Methods: A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7
BACKGROUND: Group B Streptococcus (GBS) transmission during pregnancy causes preterm labor, stillbirths, fetal injury, or neonatal infections. Rates of adult infections are also rising. The GBS-NN vaccine, engineered by fusing N-terminal domains of GBS Alpha C and Rib proteins, is safe in healthy, nonpregnant women, but further assessment is needed for use during pregnancy. Here, we tested GBS-NN
BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat
Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered thre
PURPOSE: We conducted a cross-sectional study to evaluate long-term outcomes of epilepsy surgery in tuberous sclerosis complex (TSC) in a Swedish population.METHODS: Demographic and seizure data was retrieved from the Swedish National Epilepsy Surgery Registry and medical records. Patient reported outcome measurements (PROM) were determined by telephonic interviews at long term follow-up.RESULTS:
Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages1-3. Similar to how eukaryotic innate immune systems sense foreign invaders through pathogen-associated molecular patterns4 (PAMPs), many bacterial immune systems that respond to bacteriophage infection require phage-specific triggers to be activated. However, the identities of s
