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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192215 hits

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A search is presented for the pair production of heavy vectorlike quarks (VLQs) that each decay into a W boson and a light quark. This study focuses on events where one W boson decays into leptons and the other into hadrons. The search analyzed 140 fb−1 of pp collision data with pffiffi s ¼ 13 TeV, recorded by the ATLAS detector from 2015 to 2018 during run 2 of the Large Hadron Collider. The fina

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Deoxyribonucleic acid or DNA is one of the most fundamental molecules of life as it encodes the basic structure of every living entity, including us. Not only is DNA responsible for precisely describing every single aspect that makes us, it also directly affects the world around us. Indeed, unlocking the genetic code embedded in DNA already enabled us to create new diagnostics that allow us to det

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Background: Researchers have shown an increased interest in involving professionals from outside academia in research projects. Professionals are often involved in research on ageing and health when the purpose is to address the gap between research and practice. However, there is a need to acquire more knowledge about what the involvement might lead to by exploring researchers’ experiences of inv

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Despite the central role supervision plays inshaping students’ academic and professional development,Swedish regulations offer limited guidance on MSc thesissupervision by PhD students. This study conducted aqualitative research design and thematic analysis to explore theexperiences and challenges of PhD students supervising MSctheses and master’s students supervised by PhD candidates atthe Facult

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A search for Higgs boson pair production in events with two b-jets and two τ-leptons is presented, using a proton–proton collision dataset with an integrated luminosity of 139 fb −1 collected at s = 13 TeV by the ATLAS experiment at the LHC. Higgs boson pairs produced non-resonantly or in the decay of a narrow scalar resonance in the mass range from 251 to 1600 GeV are targeted. Events in which at

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Background: Diabetes has been recognized as a risk factor contributing to the incidence and progression of Parkinson’s disease (PD). Although several hypotheses suggest a number of different mechanisms underlying the aggravation of PD caused by diabetes, less attention has been paid to the fact that diabetes and PD share pathological microvascular alterations in the brain. The characteristics of t

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A search for new phenomena is presented in final states with two leptons and one or no b-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full run-2 proton-proton collision dataset recorded at a center-of-mass energy of s=13 TeV by the ATLAS experiment at the LHC, corres

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Tungsten is a prime candidate material for use in plasma facing components in nuclear fusion reactors. This would entail weathering extreme conditions, such as high thermal loads and particle bombardment. It is of vital importance to understand how tungsten mechanically responds to these conditions, and how it is impacted by the defects that form. The current communication considers how the mechan

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Ion exchange membranes (IEMs) have consolidated applications in energy conversion and storage systems, like fuel cells and battery separators. Moreover, in the perspective to address the global need for non-carbon-based and renewable energies, salinity-gradient power (SGP) harvesting by reverse electrodialysis (RED) is attracting significant interest in recent years. In particular, brine solutions

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Land-cover changes have a clear impact on local climates via biophysical effects. European land cover has been affected by human activities for at least 6000 years, but possibly longer. It is thus highly probable that humans altered climate before the industrial revolution (AD1750–1850). In this study, climate and vegetation 6000 years (6 ka) ago is investigated using one global climate model, two

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Amyloid-PET quantification through the tracer-independent Centiloid (CL) scale has emerged as an essential tool for the accurate measurement of amyloid-β (Aβ) pathology in Alzheimer's disease (AD) patients. The AMYPAD consortium set out to integrate existing literature and recent work from the consortium to provide clinical context-of-use recommendations for the CL scale. Compared to histopatholog

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Background and objective: Guideline recommendations regarding early management of grade group (GG) 2 prostate cancer with confirmatory biopsy (cBx) are not well established. Our aim was to determine which patients with GG 2 cancer should undergo cBx before treatment decision-making by evaluating the probability of downgrading to GG 1 or no cancer on cBx. Methods: This was a single-institution retr

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The Paris Agreement of the United Nations Framework Convention on Climate Change is a binding international treaty signed by 196 nations to limit their greenhouse gas emissions through ever-reducing Nationally Determined Contributions and a system of 5-yearly Global Stocktakes in an Enhanced Transparency Framework. To support this process, the European Commission initiated the design and developme

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STUDY QUESTION: Can the alleged association between ovarian endometriosis and ovarian carcinoma be substantiated by genetic analysis of endometriosis diagnosed prior to the onset of the carcinoma?SUMMARY ANSWER: The data suggest that ovarian carcinoma does not originate from ovarian endometriosis with a cancer-like genetic profile; however, a common precursor is probable.WHAT IS KNOWN ALREADY: End

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Purpose: Currently, foresight studies have been adapted to incorporate new techniques based on big data and machine learning (BDML), which has led to new approaches and conceptual changes regarding uncertainty and how to prospect future. The purpose of this study is to explore the effects of BDML on foresight practice and on conceptual changes in uncertainty.Design/methodology/approach: The method

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Background: The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens. Methods: Participants were recruited from the West Asthma Sweden Study, a population-based study enriched w

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Gastrointestinal stromal tumors (GISTs) are predominantly initiated by KIT mutations. In this study, we observed that discoidin domain receptors 1 and 2 (DDR1 and DDR2) exhibited high expression in GISTs, were associated with KIT, and enhanced the activation of both wild-type KIT and primary KIT mutants. Inhibition of DDR1/2 led to a reduction in the activation of KIT and its downstream signaling