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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193029 hits

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A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The accurate prediction of blood glucose levels in response to inputs would support the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this bac

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This paper analyses the integration of social considerations into public transport planning. It addresses the challenge of balancing social benefits against objectives such as efficiency and cost minimization. Through a literature review, this paper examines methods for assessing public transport accessibility for potentially disadvantaged groups and identifies knowledge gaps in existing research.

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Purpose: Different imaging tools, including digital breast tomosynthesis (DBT), are frequently used for evaluating tumor response during neoadjuvant chemotherapy (NACT). This study aimed to explore whether using artificial intelligence (AI) for serial DBT acquisitions during NACT for breast cancer can predict pathological complete response (pCR) after completion of NACT. Methods: A total of 149 wo

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We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive car

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Many governments worldwide have proposed transitioning from a fossil-based economy to a bioeconomy to address climate change, resource depletion, and other environmental concerns. The bioeconomy utilizes renewable biological resources across all sectors and is strongly founded on scientific advances and technological progress. Given that the bioeconomy spans multiple sectors, industries, and techn

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OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive adjunct to multimodal pain management for acute postoperative care across various surgeries. Despite extensive evidence supporting its efficacy, TENS remains underutilized in clinical practice. This study aimed to assess the knowledge, attitudes, and practices of healthcare professionals regarding TENS in perioperative

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Demonstrating how strategic communication management creates value has long been considered a key challenge for communication departments and managers. Theorizing and explaining how strategic communication creates value and how this value can be demonstrated has, therefore, emerged as a central research concern in public relations and strategic communication. While extant literature acknowledges t

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PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,

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During the energy crisis in 2022/2023, households across Europe were encouraged to reduce their energy use to contribute to energy sufficiency, sovereignty, and solidarity. This paper explores energy saving heating practices among Swedish single-family households during the energy crisis in 2022. The Energy Cultures Framework is used to investigate how material culture and norms affect practices f

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Anthropogenic land-use change (LUC) substantially impacts climate dynamics, primarily through modifications in the surface biogeophysical (BGP) and biogeochemical (BGC) fluxes, which alter the exchange of energy, water, and carbon with the atmosphere. Despite the established significance of both the BGP and BGC effects, their relative contribution to climate change remains poorly quantified. In th

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Phlorotannins, the polyphenols mostly found in brown seaweeds, have attracted high attention from the pharmaceutical industry in recent years due to their antioxidant, antibacterial, and anti-inflammatory activities. These properties make them desirable to be utilized in a wide range of therapeutics. Despite their importance, several challenges make their extractability and identification complex,

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Non-Hermitian physics, studying systems described by non-Hermitian Hamiltonians, reveals unique phenomena not present in Hermitian systems. Unlike Hermitian systems, non-Hermitian systems have complex eigenvalues, making their effects less directly observable. Recently, significant efforts have been devoted to incorporating the non-Hermitian effects into condensed matter physics. However, progress

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This work describes and characterizes an algorithm for the nonambiguous reduction of multiexponentially decaying luminescence signals to scalar values of corresponding calibration temperatures. Previous evaluation schemes in phosphor thermometry make use of an intermediate step, where data reduction is achieved by fitting a model equation to phosphorescence decays in order to translate one or more

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Abstract Background: Empowerment is essential in the rehabilitation process for people with psychiatric disabilities and knowledge about factors that may play a key role within this process would be valuable for further development of the day centre services. Objective: The present study investigates day centre attendees' perceptions of empowerment. The aim was to investigate which factors show th

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Adipose tissue has an important function in total energy homeostasis and its dysregulation may contribute to life-style related diseases such as type 2 diabetes, cancer and cardiovascular diseases. The aim of this study was to investigate genome-wide mRNA expression in adipose tissue in healthy men before and after an exercise intervention to identify genes or pathways that mediate the beneficial

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BACKGROUND/AIMS: Improved data and methods are needed for modeling disease progression in Alzheimer's disease (AD) for economic evaluation of treatments. The aim is to estimate prediction models for long-term AD progression and subsequently economic outcomes. METHODS: Three-year follow-up data on 435 patients treated with the cholinesterase inhibitor donepezil in clinical practise were analyzed.