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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193029 hits

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A major drawback of the defibration or refining process in manufacturing pulp is that of its large energy requirements. If the mechanics of the process were better understood, large amounts of energy could probably be saved. The initial defibration seems to be crucial for both the quality of the pulp and the total consumption of energy. Numerical simulations by means of the finite element method r

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Nitrogenase is the only enzyme that can convert N2 to NH3. Crystallographic structures have indicated that one of the sulfide ligands of the active-site FeMo cluster, S2B, can be replaced by an inhibitor, like CO and OH−, and it has been suggested that it may be displaced also during the normal reaction. We have investigated possible proton transfer pathways within the FeMo cluster during the

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Plastics is a group of materials commonly encountered on a daily basis by many people. They have enabled rapid, low-cost manufacturing of products with complicated geometries and have contributed to the weight reduction of heavy components, especially when produced into a foamed structure. Despite the many advantages of plastics, some drawbacks such as the often fossil-based raw-material and the e

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Desalination to increase irrigation water supply for agricultural production is becoming important in water scarce regions. While desalination has positive effects on the potential irrigation water quantity and quality, the technique may also be a considered as potential source of groundwater pollution. The present study investigated the effects of desalination wastewater discharge on groundwater

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Hypomyelination is observed in the context of a growing number of genetic disorders that share clinical characteristics. The aim of this study was to determine the possible role of magnetic resonance imaging pattern recognition in distinguishing different hypomyelinating disorders, which would facilitate the diagnostic process. Only patients with hypomyelination of known cause were included in thi

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Background & Objective: Patients with mild hypothyroidism often are depressed and have impaired quality of life despite serum free-T4 and T3 within reference values. Therefore, we investigated whether their symptoms were dependent on the concentrations of free -T4 and T3 in the circulation and cerebrospinal fluid (CSF). Methods: Twenty-five newly diagnosed, untreated hypothyroid subjects and a

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Background: West Virginia has one of the highest rates of opioid overdose related deaths and is known as the epicenter of the opioid crisis in the United States. In an effort to reduce opioid-related harms, SB 273 was signed in 2018, and aimed to restrict opioid prescribing in West Virginia. SB 273 was enacted during a time when physician arrests and convictions had been increasing for years and w

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Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been proven useful to characterize MPs. Both protein and non-protein molecular belts have shown promise to maintain the structural integrity of MPs in lipid nanodiscs. Small-angle neutron scattering (SANS) can be used to determine low-resolution struc

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Morpho-taxonomic studies of cetrarioid lichens from India recorded 46 species representing Cetraria, Melanelia, Nephromopsis, and Platismatia. Nephromopsis awasthii is described as new to science; and Cetraria endochrysea, C. sinensis, Melanelia agnata, Nephromopsis ciliaris, N. morrisonicola, N. pseudocomplicata, N. pseudoweberi, N. rugosa, N. weii, and N. yunnanensis are reported for the first tMorpho-taxonomic studies of cetrarioid lichens from India recorded 46 species representing Cetraria, Melanelia, Nephromopsis, and Platismatia. Nephromopsis awasthii is described as new to science; and Cetraria endochrysea, C. sinensis, Melanelia agnata, Nephromopsis ciliaris, N. morrisonicola, N. pseudocomplicata, N. pseudoweberi, N. rugosa, N. weii, and N. yunnanensis are reported for the first t

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Background: European treatment guidelines recommend prasugrel over ticagrelor for treating patients with non–ST-elevation acute coronary syndrome (ACS), prompting several Swedish administrative regions to transition from ticagrelor to prasugrel as the preferred treatment for patients with ACS. We aim to systematically evaluate this transition to determine the relative efficacy of prasugrel versus

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The present paper reports different applications which have a common data source: Automatic Road Analyzer (ARAN) of the Transport Infrastructure Laboratory of the University of Catania. Data surveyed with ARAN were used to develop performance indicators of the road asset. A BIM model makes possible to improve the flexibility in information access and to merge data with the aim to allow a complete

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Low temperature combustion concepts used in compression ignition engines have shown to be able to produce simultaneous reduction of oxides of nitrogen and soot as well as generating higher gross indicated efficiencies compared to conventional diesel combustion. This is achieved by a combination of premixing, dilution and optimization of com

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The ongoing climate change can modulate the behavior of global vegetation and influence the terrestrial biosphere carbon sink. Past observation-based studies have mainly focused on the linear trend or interannual variability of the vegetation greenness, but could not explicitly deal with the effect of natural decadal variability due to the short length of observations. Here we put the variabilitie

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Forskare och praktiker betonar alltmer vikten av tvärvetenskapliga och experimentella sätt att förstå och bemöta hållbarhetsutmaningar. Det finns en bred enighet om att samhället måste genomgå djupa och radikala förändringar, alltså omvandling (transformation). Men detta berorpå många dynamiska faktorer i lokala sammanhang. I denna avhandling utforskar jag hur man kan främja experimentella tvärvetScholars and practitioners increasingly emphasize the importance of transdisciplinary and experimental approaches for understanding and addressing sustainability challenges. While there is widespread agreement that human society must undergo deep and radical changes, or so-called transformation, how transformation happens depends on multiple and dynamic factors in local contexts. In this thesis, I

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The configuration-dependent shell-correction approach with the cranked Nilsson potential is employed for a systematic investigation of the high-spin spectra of the nuclei in the A ∼ 135 (Z = 57-61, N = 72-78) mass region, where superdeformed bands have been observed. Main attention is paid to the coexistence of intruder νi13/2, superdeformed and terminating bands in the yrast region. Recent develo

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Currently, there is limited knowledge on how the Swedish strategy with more lenient public health restrictions during the COVID-19 pandemic has influenced people's life satisfaction. Here, we investigated self-reported life satisfaction during the first wave of the pandemic in Sweden, and perceived changes in life satisfaction in relation to various sociodemographic factors. A total of 1082 people