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Older Adults with Autism Spectrum Disorders in Sweden : A Register Study of Diagnoses, Psychiatric Care Utilization and Psychotropic Medication of 601 Individuals

In a Swedish sample of persons eligible for disability services and aged 55 years or older in 2012, persons (n = 601) with autism spectrum disorder diagnoses registered in specialist care were identified. Register data concerning diagnoses of other psychiatric disorders, psychiatric care, and psychiatric medication were reviewed. More than 60% had been in contact with psychiatric care. The majorit

Patents, Morality and Biomedical Innovation in Europe : Historical overview, current debates on stem cells, gene editing and AI, and de lege ferenda reflections

This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate

Utility of G protein-coupled receptor 35 expression for predicting outcome in colon cancer

The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage

Effect of level of sedation on outcomes in critically ill adult patients : a systematic review of clinical trials with meta-analysis and trial sequential analysis

Background: Sedation is routinely administered to critically ill patients to alleviate anxiety, discomfort, and patient-ventilator asynchrony. However, it must be balanced against risks such as delirium and prolonged intensive care stays. This study aimed to investigate the effects of different levels of sedation in critically ill adults. Methods: Systematic review with meta-analysis and trial seq

Impact of xylose epimerase on sugar assimilation and sensing in recombinant Saccharomyces cerevisiae carrying different xylose-utilization pathways

BackgroundOver the last decades, many strategies to procure and improve xylose consumption in Saccharomyces cerevisiae have been reported. This includes the introduction of efficient xylose-assimilating enzymes, the improvement of xylose transport, or the alteration of the sugar signaling response. However, different strain backgrounds are often used, making it difficult to determine if the findin

Tracking the Reinstatement of Semantic and Emotional Information during Episodic Memory Retrieval

Retrieving episodic memories often involves reconstructing both their semantic content and the emotional context in which they occurred. However, the neural mechanisms that differentiate these forms of reinstatement remain poorly understood. This event-related potential (ERP) study examines how semantic category and emotional valence are reinstated during memory retrieval.Seventy participants enco

A knowledge integration framework for robotics

This paper describes a knowledge integration framework for robotics, whose goal is to represent, store, adapt, and distribute knowledge across engineering platforms. The architecture abstracts the components as data sources, where data are available in the AutomationML data exchange format. AutomationML is an on-going standard initiative that aims at unifying data representation and APIs used by e

Optimal Virtual Array Length Under Position Imperfections

This article contains a study of how spatial errors and receiver imperfections affect the angle of arrival estimation accuracy for virtual antenna arrays. A virtual antenna array consists of one receiver element whose location is tracked as the element is moved and in this work, linear arrays are studied. If the location of the receiver is tracked using an inertial measurement unit, an interesting

The Employment Contract Revisited.

This article considers recent legal developments on undocumented migrant workers, finds the acceptance of international legal standards unsatisfactory and argues that the private law rights derived from the "semi-legal" employment contract between the employer and the undocumented migrant worker generates a solid base for significant legal claims. It further monitors the promotion of the position

Aerosolsammansättning i ett renluftsområde

Aerosolsammansättningen i ett renluftsområde i Mellansverige (Velen) har studerats under en årscykel. Aerosolpartiklarna har uppdelats efter aerodynamisk storlek i 7 fraktioner. Varje fraktion från 113 provtagningstillfällen har analyserats m a p svavel och tungmetaller m h a partikelinducerad röntgenstrålning s k PIXE-analys. Resultaten påvisar variationer i ämneskoncentrationer mellan enskilda m

Climate change and energy policy efforts in Chile: Up in smoke?

Abstract in UndeterminedThe purpose of this study is to preliminarily evaluate Chile’s energy and climate policy performance historically (1971-2007). The objective is to estimate different indicators in relation to energy and CO2 emission intensities, and identify policy instruments in the light of estimated trends and related structural issues. The methodology is based on a top-down decompositio

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertrophic zone but declines abruptly in the hypertrophic zone, suggesting that Sox9 downregulation in hypertrophic chondrocytes might be a necessary step

Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression sever

Timing of gazes in child dialogues: a time-course analysis of requests and back channelling in referential communication.

Background: This study investigates gaze behaviour in child dialogues. In earlier studies the authors have investigated the use of requests for clarification and responses in order to study the co-creation of understanding in a referential communication task. By adding eye tracking, this line of research is now expanded to include non-verbal contributions in conversation. Aims: To investigate